Glucagon antagonism as a potential therapeutic target in type 2 diabetes

The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action

(2010) K. J. Hare et al.   DIABETES

Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus

(2009) K. Aaboe et al.   DIABETES OBESITY & METABOLISM

The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides

(2009) Thomas A. Knappe et al.   FEBS LETTERS

Human Glucagon Receptor Antagonists with Thiazole Cores. A Novel Series with Superior Pharmacokinetic Properties

(2009) Peter Madsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible  -Cell Hyperplasia and Hyperglucagonemia

(2009) W. Gu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Homozygous P86S Mutation of the Human Glucagon Receptor Is Associated With Hyperglucagonemia, α Cell Hyperplasia, and Islet Cell Tumor

(2009) Cuiqi Zhou et al.   PANCREAS

Discovery of potent, orally active benzimidazole glucagon receptor antagonists

(2008) Ronald M. Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

(2008) J. de Heer et al.   DIABETOLOGIA

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY

Nesidioblastosis and Hyperplasia of ?? Cells, Microglucagonoma, and Nonfunctioning Islet Cell Tumor of the Pancreas

(2008) Run Yu et al.   PANCREAS