Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

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Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects

(2013) Kim Ravnskjaer et al.   JOURNAL OF CLINICAL INVESTIGATION

What causes the insulin resistance underlying obesity?

(2013) Olga T. Hardy et al.   Current Opinion in Endocrinology Diabetes and Obesity

Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States

(2013) Abdelfattah El Ouaamari et al.   Cell Reports

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2

(2012) Q. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

(2011) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of the CREB-specific coactivator TORC2 at Ser307 regulates its intracellular localization in COS-7 cells and in the mouse liver

(2010) Tatsuya Uebi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CRTC3 links catecholamine signalling to energy balance

(2010) Youngsup Song et al.   NATURE

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

(2009) Maziyar Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ablation of ARNT/HIF1β in Liver Alters Gluconeogenesis, Lipogenic Gene Expression, and Serum Ketones

(2009) Xiaohui L. Wang et al.   Cell Metabolism

CRTC2 (TORC2) Contributes to the Transcriptional Response to Fasting in the Liver but Is Not Required for the Maintenance of Glucose Homeostasis

(2009) John Le Lay et al.   Cell Metabolism

Hepatic triacylglycerol accumulation and insulin resistance

(2008) Cynthia A. Nagle et al.   JOURNAL OF LIPID RESEARCH

Hepatic Glucose Sensing via the CREB Coactivator CRTC2

(2008) R. Dentin et al.   SCIENCE