标题
Impaired insulin action in the human brain: causes and metabolic consequences
作者
关键词
-
出版物
Nature Reviews Endocrinology
Volume 11, Issue 12, Pages 701-711
出版商
Springer Nature
发表日期
2015-10-13
DOI
10.1038/nrendo.2015.173
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Response to Comment on Heni et al. Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men. Diabetes 2014;63:4083–4088
- (2015) Martin Heni et al. DIABETES
- Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin
- (2015) Denovan P. Begg et al. DIABETES
- Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?: Figure 1
- (2015) Dale S. Edgerton et al. DIABETES
- Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans
- (2015) Sofiya Gancheva et al. DIABETES
- Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults
- (2015) Stephanie Kullmann et al. DIABETES CARE
- Insulin Action in the Human Brain: Evidence from Neuroimaging Studies
- (2015) S. Kullmann et al. JOURNAL OF NEUROENDOCRINOLOGY
- Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
- (2015) Maartje S. Spetter et al. MOLECULAR PHARMACEUTICS
- Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsiveness
- (2015) Angie C.N. Chong et al. Molecular Metabolism
- The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?
- (2015) Tina Sartorius et al. PLoS One
- Brain metabolic dysfunction at the core of Alzheimer's disease
- (2014) Suzanne M. de la Monte et al. BIOCHEMICAL PHARMACOLOGY
- Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding
- (2014) Merly C. Vogt et al. CELL
- Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes
- (2014) Hui Zhang et al. DIABETES
- Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia
- (2014) Volker Ott et al. DIABETES
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
- (2014) A. Kleinridders et al. DIABETES
- Insulin Regulates Brain Function, but How Does It Get There?
- (2014) S. M. Gray et al. DIABETES
- Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men
- (2014) M. Heni et al. DIABETES
- Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease
- (2014) M. Yarchoan et al. DIABETES
- Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations
- (2014) Satya Dash et al. DIABETES
- Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity
- (2014) Katarzyna Linder et al. DIABETOLOGIA
- Mapping glucose-mediated gut-to-brain signalling pathways in humans
- (2014) Tanya J. Little et al. NEUROIMAGE
- Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide
- (2014) Krzysztof Łabuzek et al. Pharmacological Reports
- Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans
- (2013) Martin Heni et al. ACTA DIABETOLOGICA
- Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
- (2013) Jessica Freiherr et al. CNS DRUGS
- Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese
- (2013) Jetro J. Tuulari et al. DIABETES
- Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes
- (2013) Vera Novak et al. DIABETES CARE
- A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review
- (2013) B. M. Frier et al. DIABETES OBESITY & METABOLISM
- Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats
- (2013) Denovan P. Begg et al. ENDOCRINOLOGY
- Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults
- (2013) Martin Heni et al. HUMAN BRAIN MAPPING
- Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways
- (2013) Kathleen A. Page et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Intranasal Insulin Reduces Olfactory Sensitivity in Normosmic Humans
- (2013) Yvonne F. Brünner et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans
- (2013) K. Alexander Iwen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Cooperation between brain and islet in glucose homeostasis and diabetes
- (2013) Michael W. Schwartz et al. NATURE
- Polymorphism rs3123554 inCNR2reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action
- (2013) Caroline Ketterer et al. Obesity
- Correction: Learning and Long-Term Retention of Large-Scale Artificial Languages
- (2013) Michael C. Frank et al. PLoS One
- Risk of postprandial insulin resistance: The liver/vagus rapport
- (2013) Maria Paula Macedo et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex
- (2013) Martin Heni et al. Molecular Metabolism
- Evidence against a Physiologic Role for Acute Changes in CNS Insulin Action in the Rapid Regulation of Hepatic Glucose Production
- (2012) Christopher J. Ramnanan et al. Cell Metabolism
- Selective Insulin and Leptin Resistance in Metabolic Disorders
- (2012) A. Christine Könner et al. Cell Metabolism
- Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production
- (2012) Beatrice M. Filippi et al. Cell Metabolism
- Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity
- (2012) Tina Sartorius et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Short-Term Caloric Restriction Normalizes Hypothalamic Neuronal Responsiveness to Glucose Ingestion in Patients With Type 2 Diabetes
- (2012) W. M. Teeuwisse et al. DIABETES
- Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans
- (2012) K. Jauch-Chara et al. DIABETES
- Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
- (2012) M. Hallschmid et al. DIABETES
- Neural Correlates of Stress- and Food Cue-Induced Food Craving in Obesity: Association with insulin levels
- (2012) A. M. Jastreboff et al. DIABETES CARE
- Estimating insulin sensitivity and beta cell function: perspectives from the modern pandemics of obesity and type 2 diabetes
- (2012) J. J. Nolan et al. DIABETOLOGIA
- Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
- (2012) M. Heni et al. DIABETOLOGIA
- Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture
- (2012) Tina Sartorius et al. FASEB JOURNAL
- (Still) longing for food: Insulin reactivity modulates response to food pictures
- (2012) Nils B. Kroemer et al. HUMAN BRAIN MAPPING
- Intranasal delivery of insulin via the olfactory nerve pathway
- (2012) Dan B. Renner et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
- (2012) Kevin W Williams et al. NATURE NEUROSCIENCE
- SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
- (2012) Ele Ferrannini et al. Nature Reviews Endocrinology
- Insulin resistance and AD—extending the translational path
- (2012) Suzanne Craft Nature Reviews Neurology
- The many faces of insulin-like peptide signalling in the brain
- (2012) Ana M. Fernandez et al. NATURE REVIEWS NEUROSCIENCE
- Intranasal Insulin Modulates Intrinsic Reward and Prefrontal Circuitry of the Human Brain in Lean Women
- (2012) Stephanie Kullmann et al. NEUROENDOCRINOLOGY
- CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age
- (2012) Merly C. Vogt et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis
- (2011) Thomas Scherer et al. Cell Metabolism
- Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice
- (2011) C. P. Coomans et al. DIABETES
- Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
- (2011) J. Hirvonen et al. DIABETES
- Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-analysis
- (2011) A. E. Pontiroli et al. DIABETES OBESITY & METABOLISM
- Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
- (2011) V. Ott et al. DIABETES OBESITY & METABOLISM
- Insulin sensitivity of the human brain
- (2011) Caroline Ketterer et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial
- (2011) U. Stockhorst et al. DIABETOLOGIA
- High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
- (2011) O. Tschritter et al. DIABETOLOGIA
- The obese brain: Association of body mass index and insulin sensitivity with resting state network functional connectivity
- (2011) Stephanie Kullmann et al. HUMAN BRAIN MAPPING
- Leptin Therapy in a Congenital Leptin-Deficient Patient Leads to Acute and Long-Term Changes in Homeostatic, Reward, and Food-Related Brain Areas
- (2011) Sabine Frank et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Activation of KATP channels suppresses glucose production in humans
- (2011) Preeti Kishore et al. JOURNAL OF CLINICAL INVESTIGATION
- Circulating insulin stimulates fatty acid retention in white adipose tissue via KATPchannel activation in the central nervous system only in insulin-sensitive mice
- (2011) Claudia P. Coomans et al. JOURNAL OF LIPID RESEARCH
- The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects
- (2011) Martina Guthoff et al. PLoS One
- Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
- (2011) Thomas Scherer et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects
- (2010) M. Hallschmid et al. DIABETES
- Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
- (2010) C. Benedict et al. DIABETES
- Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects
- (2010) C Ketterer et al. INTERNATIONAL JOURNAL OF OBESITY
- Cerebrospinal fluid insulin during non-neurological surgery
- (2010) Sara Bromander et al. JOURNAL OF NEURAL TRANSMISSION
- Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids
- (2010) Alexander Krogmann et al. MICROVASCULAR RESEARCH
- Memory formation and long-term retention in humans and animals: Convergence towards a transformation account of hippocampal–neocortical interactions
- (2010) Gordon Winocur et al. NEUROPSYCHOLOGIA
- Insulin and Hippocampus Activation in Response to Images of High-Calorie Food in Normal Weight and Obese Adolescents
- (2010) Sandra Wallner-Liebmann et al. Obesity
- Toll-like receptors: linking inflammation to metabolism
- (2010) A. Christine Könner et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?
- (2009) M. Hallschmid et al. DIABETOLOGIA
- Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity
- (2009) A. M. Hennige et al. DIABETOLOGIA
- The Insulin Effect on Cerebrocortical Theta Activity Is Associated with Serum Concentrations of Saturated Nonesterified Fatty Acids
- (2009) Otto Tschritter et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Insulin Modulates Food-Related Activity in the Central Nervous System
- (2009) Martina Guthoff et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Insulin effects on beta and theta activity in the human brain are differentially affected by ageing
- (2008) O. Tschritter et al. DIABETOLOGIA
- Variation in the FTO Gene Influences Food Intake but not Energy Expenditure
- (2008) A. Haupt et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin
- (2008) Christian Benedict et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hypothalamic alterations in fetuses of high fat diet-fed obese female rats
- (2008) Anshu Gupta et al. JOURNAL OF ENDOCRINOLOGY
- Intranasal insulin attenuates the hypothalamic–pituitary–adrenal axis response to psychosocial stress
- (2008) Andreas Bohringer et al. PSYCHONEUROENDOCRINOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started