Autophagy in synaptic development, function, and pathology

Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates

(2015) Ilaria Luccarini et al.   NEUROBIOLOGY OF AGING

Synapses, spines and kinases in mammalian learning and memory, and the impact of aging

(2015) Eddy A. van der Zee   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Impaired intracellular trafficking defines early Parkinson's disease

(2015) Benjamin H.M. Hunn et al.   TRENDS IN NEUROSCIENCES

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

(2015) Beyenech Binotti et al.   eLife

β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice

(2014) Yunbo Chen et al.   BRAIN RESEARCH

Sorting out the trash: the spatial nature of eukaryotic protein quality control

(2014) Emily M Sontag et al.   CURRENT OPINION IN CELL BIOLOGY

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes

(2014) Meng-meng Fu et al.   DEVELOPMENTAL CELL

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

(2014) Sandra Maday et al.   DEVELOPMENTAL CELL

Defective Autophagy in Parkinson’s Disease: Lessons from Genetics

(2014) H. Zhang et al.   MOLECULAR NEUROBIOLOGY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Shaping Dendritic Spines in Autism Spectrum Disorder: mTORC1-Dependent Macroautophagy

(2014) Heather Bowling et al.   NEURON

Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission

(2014) Michael V. Accardi et al.   Nature Communications

Alpha-synuclein spreading in Parkinson’s disease

(2014) Ariadna Recasens et al.   Frontiers in Neuroanatomy

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Synaptic Health

(2014) John H. Morrison et al.   JAMA Psychiatry

Autophagy in ageing and ageing-associated diseases

(2013) Li-qiang He et al.   ACTA PHARMACOLOGICA SINICA

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

(2013) Muzamil Majid Khan et al.   Autophagy

The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe/ZnS quantum dots

(2013) Liang Chen et al.   BIOMATERIALS

Distinct Roles for Somatically and Dendritically Synthesized Brain-Derived Neurotrophic Factor in Morphogenesis of Dendritic Spines

(2013) L. L. Orefice et al.   JOURNAL OF NEUROSCIENCE

The mTOR Signaling Pathway Regulates Pain-Related Synaptic Plasticity in Rat Entorhinal-Hippocampal Pathways

(2013) Dan Lyu et al.   Molecular Pain

The Dynamic Synapse

(2013) Daniel Choquet et al.   NEURON

Is There a Role for Nitric Oxide in Methamphetamine-Induced Dopamine Terminal Degeneration?

(2013) Danielle M. Friend et al.   NEUROTOXICITY RESEARCH

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

(2013) Jun-yi Zhu et al.   PLoS One

Electroconvulsive seizures enhance autophagy signaling in rat hippocampus

(2013) Hiroyuki Otabe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Autophagy in axonal and dendritic degeneration

(2013) Yi Yang et al.   TRENDS IN NEUROSCIENCES

Sonic hedgehog promotes autophagy in hippocampal neurons

(2013) R. S. Petralia et al.   Biology Open

Macroautophagy can press a brake on presynaptic neurotransmission

(2012) Ciara A. Torres et al.   Autophagy

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration

(2012) Adam Haberman et al.   JOURNAL OF CELL BIOLOGY

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Snapin is Critical for Presynaptic Homeostatic Plasticity

(2012) D. K. Dickman et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Structural plasticity upon learning: regulation and functions

(2012) Pico Caroni et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

(2012) Stephen G. Brickley et al.   NEURON

Remodeling of synapses in the CA1 area of the hippocampus after transient global ischemia

(2012) Y.-W. Ruan et al.   NEUROSCIENCE

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation

(2011) Christelle En Lin Chua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative stress in synapse development and function

(2011) Valerie J. Milton et al.   Developmental Neurobiology

Microtubule and kinesin/dynein-dependent, bi-directional transport of autolysosomes in neurites of PC12 cells

(2011) Yi Yang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons

(2011) Jaewon Ko et al.   JOURNAL OF CELL BIOLOGY

Local RNA Translation at the Synapse and in Disease

(2011) L. Liu-Yesucevitz et al.   JOURNAL OF NEUROSCIENCE

Ubiquitin Homeostasis Is Critical for Synaptic Development and Function

(2011) P.-C. Chen et al.   JOURNAL OF NEUROSCIENCE

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons

(2011) Xiaolin Tian et al.   NATURE NEUROSCIENCE

CYY-1/Cyclin Y and CDK-5 Differentially Regulate Synapse Elimination and Formation for Rewiring Neural Circuits

(2011) Mikyoung Park et al.   NEURON

Oxidative stress induces overgrowth of the Drosophila neuromuscular junction

(2011) V. J. Milton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic dysfunction in genetic models of Parkinson's disease: A role for autophagy?

(2010) Edward D. Plowey et al.   NEUROBIOLOGY OF DISEASE

Altered Hippocampal Synaptic Physiology in Aged Parkin-Deficient Mice

(2010) Jesse E. Hanson et al.   NEUROMOLECULAR MEDICINE

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

(2010) Qian Cai et al.   NEURON

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling

(2009) Y. P. Wairkar et al.   JOURNAL OF NEUROSCIENCE

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila

(2009) Y. Batlevi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA