Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity

(2016) Steven L. Jones et al.   NEURAL PLASTICITY

Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells

(2015) Carmen Laura Sayas et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease

(2014) Tae-In Kam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments

(2014) Steven L. Jones et al.   JOURNAL OF CELL BIOLOGY

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology

(2013) Makoto Hara et al.   ACTA NEUROPATHOLOGICA

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease

(2013) Miguel Medina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

(2013) M. Goedert et al.   Cold Spring Harbor Perspectives in Medicine

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau

(2012) Ann Van der Jeugd et al.   ACTA NEUROPATHOLOGICA

The Physiology of the Axon Initial Segment

(2012) Kevin J. Bender et al.   Annual Review of Neuroscience

GSK3 and β-catenin determines functional expression of sodium channels at the axon initial segment

(2012) Mónica Tapia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF

(2012) Qian Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

The axon initial segment in nervous system disease and injury

(2011) Shelly A. Buffington et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Tau splicing and the intricacies of dementia

(2011) Athena Andreadis   JOURNAL OF CELLULAR PHYSIOLOGY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Early Improved and Late Defective Cognition Is Reflected by Dendritic Spines in Tau.P301L Mice

(2011) A. Kremer et al.   JOURNAL OF NEUROSCIENCE

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment

(2011) C. Leterrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of GSK3 Signaling in Neuronal Morphogenesis

(2011) Yun Tai Kim et al.   Frontiers in Molecular Neuroscience

Hooks and comets: The story of microtubule polarity orientation in the neuron

(2010) Peter W. Baas et al.   Developmental Neurobiology

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

The axon initial segment and the maintenance of neuronal polarity

(2010) Matthew N. Rasband   NATURE REVIEWS NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment

(2009) Ai-hong Song et al.   CELL

Pattern of tau isoforms expression during development in vivo

(2009) Torsten Bullmann et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K Pathway

(2009) Tsuyoshi Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex

(2009) Dianne A. Cruz et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY