期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 27, 期 6, 页码 591-597出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2009.06.001
关键词
Development; Neuronal differentiation; Neuronal plasticity; Neocortex; Cerebellum; Tubulin
资金
- Faculty of Medicine of the University of Leipzig [984000-102]
- Interdisciplinary Centre of Clinical Research (IZKF)
- Faculty of Medicine of the University of Leipzig awarded [C24]
- Alzheimer Forschung Initiative [02815/02501]
Neuronal morphology and axonal growth during development are correlated to specific expression of various microtubule-associated protein tau isoforms. Using RT-PCR and Western blotting we found the unexpected result that the shift from fetal towards adult isoforms does not differ between rat cerebral cortex and cerebellum, two temporally differently developing areas. By immunohistochemistry we observed a cell type specific isoform expression during development and adulthood. The developmental expression of tau isoforms was compared to the appearance of stable microtubules assessed by the immunohistochemical detection of tubulin modifications. The tau isoform shift shows an apparent disconnect to neurogenesis, migration and volume growth, but coincides with the formation of synapses and the appearance of stable microtubules. (C) 2009 ISDN. Published by Elsevier Ltd. All rights reserved.
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