New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

(2013) Undine E. Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Understanding the relationship between GSK-3 and Alzheimer’s disease: a focus on how GSK-3 can modulate synaptic plasticity processes

(2013) Miguel Medina et al.   Expert Review of Neurotherapeutics

DISC1-related signaling pathways in adult neurogenesis of the hippocampus

(2013) Qian Wu et al.   GENE

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo

(2013) M Llorens-Martín et al.   MOLECULAR PSYCHIATRY

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Glycogen Synthase Kinase-3 (GSK-3) Inhibitors for the Treatment of Alzheimers Disease

(2012) Miguel Medina et al.   CURRENT PHARMACEUTICAL DESIGN

Dual effects of increased glycogen synthase kinase-3β activity on adult neurogenesis

(2012) Almudena Fuster-Matanzo et al.   HUMAN MOLECULAR GENETICS

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease

(2012) D. E. Hurtado et al.   JOURNAL OF NEUROSCIENCE

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-  Precursor Protein

(2012) C. Parr et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease

(2012) Marcelo A. Alarcón et al.   NEUROBIOLOGY OF AGING

The Age of Olfactory Bulb Neurons in Humans

(2012) Olaf Bergmann et al.   NEURON

Selective deletion of forebrain glycogen synthase kinase 3  reveals a central role in serotonin-sensitive anxiety and social behaviour

(2012) C. Latapy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Neurological Functions of the Masterswitch Protein Kinase – Gsk-3

(2012) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness

(2011) Dinesh C. Soares et al.   ACS Chemical Neuroscience

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

(2011) Congmin Wang et al.   CELL RESEARCH

Neurodegenerative disease and adult neurogenesis

(2011) Beate Winner et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhibition of GSK3  improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

(2011) W. Guo et al.   HUMAN MOLECULAR GENETICS

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

(2011) Jean-Martin Beaulieu   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Gone with the wean

(2011) Jon I. Arellano et al.   NATURE

GSK-3α/β kinases and amyloid production in vivo

(2011) Tomasz Jaworski et al.   NATURE

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation

(2011) Satish Patel et al.   PLoS One

Different Susceptibility to Neurodegeneration of Dorsal and Ventral Hippocampal Dentate Gyrus: A Study with Transgenic Mice Overexpressing GSK3β

(2011) Almudena Fuster-Matanzo et al.   PLoS One

Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies

(2011) Miguel Medina et al.   Frontiers in Molecular Neuroscience

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Hyperactivity and Enhanced Curiosity of Mice Expressing PKB/SGK-resistant Glycogen Synthase Kinase-3 (GSK-3)

(2010) Teresa F. Ackermann et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neurogenesis and Alzheimers Disease: Biology and Pathophysiology in Mice and Men

(2010) M. Marlatt et al.   Current Alzheimer Research

Glycogen synthase kinase-3β, or a link between amyloid and tau pathology?

(2010) D. Muyllaert et al.   GENES BRAIN AND BEHAVIOR

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

(2010) Xiaohua Li et al.   NEUROPSYCHOPHARMACOLOGY

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells

(2010) Yuping Luo et al.   PLoS Genetics

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Blocked Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3α/β Impairs In Vivo Neural Precursor Cell Proliferation

(2009) Tae-Yeon Eom et al.   BIOLOGICAL PSYCHIATRY

On whether the environmental enrichment may provide cognitive and brain reserves

(2009) Laura Petrosini et al.   BRAIN RESEARCH REVIEWS

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Neurogenesis and Alzheimer's disease: At the crossroads

(2009) Orly Lazarov et al.   EXPERIMENTAL NEUROLOGY

GSK-3: A key player in neurodegeneration and memory

(2009) Karl Peter Giese   IUBMB LIFE

Αβ Hinders Nuclear Targeting of AICD and Fe65 in Primary Neuronal Cultures

(2009) A. G. Henriques et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

GSK-3 is a master regulator of neural progenitor homeostasis

(2009) Woo-Yang Kim et al.   NATURE NEUROSCIENCE

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies

(2009) Alexander Garthe et al.   PLoS One

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

(2009) Oksana Kaidanovich-Beilin et al.   Molecular Brain

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation

(2008) Se Hoon Choi et al.   NEURON

GSK-3β Is Required for Memory Reconsolidation in Adult Brain

(2008) Tetsuya Kimura et al.   PLoS One

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA