Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity

Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment

(2016) A. Freal et al.   JOURNAL OF NEUROSCIENCE

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

(2016) Marijn Kuijpers et al.   NEURON

The Ins and Outs of Polarized Axonal Domains

(2015) Daniel R. Zollinger et al.   Annual Review of Cell and Developmental Biology

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays

(2015) Sam F.B. van Beuningen et al.   NEURON

The Nodes of Ranvier: Molecular Assembly and Maintenance

(2015) Matthew N. Rasband et al.   Cold Spring Harbor Perspectives in Biology

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold

(2015) Christophe Leterrier et al.   Cell Reports

STED Nanoscopy Reveals the Ubiquity of Subcortical Cytoskeleton Periodicity in Living Neurons

(2015) Elisa D’Este et al.   Cell Reports

Giant ankyrin-G: A critical innovation in vertebrate evolution of fast and integrated neuronal signaling

(2015) Paul M. Jenkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon initial segments: diverse and dynamic neuronal compartments

(2014) Takeshi Yoshimura et al.   CURRENT OPINION IN NEUROBIOLOGY

Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments

(2014) Steven L. Jones et al.   JOURNAL OF CELL BIOLOGY

miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models

(2014) Xiaqin Sun et al.   Cell Reports

Developmental mechanism of the periodic membrane skeleton in axons

(2014) Guisheng Zhong et al.   eLife

In vivo assembly of the axon initial segment in motor neurons

(2013) Barbara Le Bras et al.   Brain Structure & Function

A NOMPC-Dependent Membrane-Microtubule Connector Is a Candidate for the Gating Spring in Fly Mechanoreceptors

(2013) Xin Liang et al.   CURRENT BIOLOGY

MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells

(2013) Elena Tortosa et al.   EMBO JOURNAL

The axon as a unique computational unit in neurons

(2013) Takuya Sasaki   NEUROSCIENCE RESEARCH

No Pasaran! Role of the axon initial segment in the regulation of protein transport and the maintenance of axonal identity

(2013) Christophe Leterrier et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Physiology of the Axon Initial Segment

(2012) Kevin J. Bender et al.   Annual Review of Neuroscience

A Distal Axonal Cytoskeleton Forms an Intra-Axonal Boundary that Controls Axon Initial Segment Assembly

(2012) Mauricio R. Galiano et al.   CELL

Cysteine 70 of Ankyrin-G IsS-Palmitoylated and Is Required for Function of Ankyrin-G in Membrane Domain Assembly

(2012) Meng He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Processing in the Axon Initial Segment

(2012) Maarten H.P. Kole et al.   NEURON

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

Networks of Polarized Actin Filaments in the Axon Initial Segment Provide a Mechanism for Sorting Axonal and Dendritic Proteins

(2012) Kaori Watanabe et al.   Cell Reports

Differential Trafficking of Transport Vesicles Contributes to the Localization of Dendritic Proteins

(2012) Sarmad Al-Bassam et al.   Cell Reports

Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B

(2011) Amandine Duflocq et al.   BMC BIOLOGY

The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia

(2011) Mirela Spillane et al.   Developmental Neurobiology

The cytoskeletal and signaling mechanisms of axon collateral branching

(2011) Gianluca Gallo   Developmental Neurobiology

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

The axon initial segment in nervous system disease and injury

(2011) Shelly A. Buffington et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

 -III Spectrin Is Critical for Development of Purkinje Cell Dendritic Tree and Spine Morphogenesis

(2011) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Piccolo Regulates the Dynamic Assembly of Presynaptic F-Actin

(2011) C. L. Waites et al.   JOURNAL OF NEUROSCIENCE

A Critical Role for Neurofascin in Regulating Action Potential Initiation through Maintenance of the Axon Initial Segment

(2011) Barbara Zonta et al.   NEURON

End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment

(2011) C. Leterrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Myosin VI in the Localization of Axonal Proteins

(2011) Tommy L. Lewis et al.   PLOS BIOLOGY

Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex

(2010) J. J. Ipsaro et al.   BLOOD

Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites

(2010) Lukas C. Kapitein et al.   CURRENT BIOLOGY

Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier

(2010) Anna Brachet et al.   JOURNAL OF CELL BIOLOGY

Casein kinase 2 and microtubules control axon initial segment formation

(2010) Diana Sanchez-Ponce et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Which way to go? Cytoskeletal organization and polarized transport in neurons

(2010) Lukas C. Kapitein et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability

(2010) Matthew S. Grubb et al.   NATURE

The axon initial segment and the maintenance of neuronal polarity

(2010) Matthew N. Rasband   NATURE REVIEWS NEUROSCIENCE

The spectrin–ankyrin–4.1–adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life

(2010) Anthony J. Baines   PROTOPLASMA

Determinants of voltage-gated sodium channel clustering in neurons

(2010) Christophe Leterrier et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A novel recessiveNeflmutation causes a severe, early-onset axonal neuropathy

(2009) Sabrina W. Yum et al.   ANNALS OF NEUROLOGY

Establishment of Axon-Dendrite Polarity in Developing Neurons

(2009) Anthony P. Barnes et al.   Annual Review of Neuroscience

The structure of the ankyrin-binding site of  -spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties

(2009) P. R. Stabach et al.   BLOOD

Structures of the spectrin-ankyrin interaction binding domains

(2009) J. J. Ipsaro et al.   BLOOD

A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment

(2009) Ai-hong Song et al.   CELL

Myosin-dependent targeting of transmembrane proteins to neuronal dendrites

(2009) Tommy L Lewis et al.   NATURE NEUROSCIENCE

Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

(2009) Wenqin Hu et al.   NATURE NEUROSCIENCE

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Electrogenic Tuning of the Axon Initial Segment

(2009) Brian D. Clark et al.   NEUROSCIENTIST

AnkyrinG is required to maintain axo-dendritic polarity in vivo

(2009) J.-M. Sobotzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell Interactions

(2009) V. Bennett et al.   Cold Spring Harbor Perspectives in Biology

Localization and Structure of the Ankyrin-binding Site on β2-Spectrin

(2008) Lydia Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

(2008) Kristian L. Hedstrom et al.   JOURNAL OF CELL BIOLOGY

Microtubules in Dendritic Spine Development

(2008) J. Gu et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic Density-93 Clusters Kv1 Channels at Axon Initial Segments Independently of Caspr2

(2008) Y. Ogawa et al.   JOURNAL OF NEUROSCIENCE

New role of IKKα/β phosphorylated IκBα in axon outgrowth and axon initial segment development

(2008) Diana Sanchez-Ponce et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila Neurons

(2008) Michelle C. Stone et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis

(2008) Sara Geraldo et al.   NATURE CELL BIOLOGY

Action potential generation requires a high sodium channel density in the axon initial segment

(2008) Maarten H P Kole et al.   NATURE NEUROSCIENCE