New Kid on the Block: LmbU Expands the Repertoire of Specialized Metabolic Regulators in Streptomyces

Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes

(2017) Hiroyasu Onaka   JOURNAL OF ANTIBIOTICS

The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis

(2017) Bingbing Hou et al.   JOURNAL OF BACTERIOLOGY

Synthetic biology to access and expand nature's chemical diversity

(2016) Michael J. Smanski et al.   NATURE REVIEWS MICROBIOLOGY

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

(2015) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal

(2015) Sergio Antoraz et al.   Frontiers in Microbiology

New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712

(2014) Lorena T. Fernández-Martínez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A roadmap for natural product discovery based on large-scale genomics and metabolomics

(2014) James R Doroghazi et al.   Nature Chemical Biology

The TetR Family of Regulators

(2013) L. Cuthbertson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Crp Is a Global Regulator of Antibiotic Production in Streptomyces

(2012) C. Gao et al.   mBio

Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin

(2009) M. J. Smanski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis

(2009) Shigeru Kitani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Hosts

(2008) Y. Chen et al.   JOURNAL OF BACTERIOLOGY

Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export

(2008) Kapil Tahlan et al.   JOURNAL OF MOLECULAR BIOLOGY