Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

(2017) Taro Ozaki et al.   Nature Communications

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis

(2016) Ryosuke Sugiyama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into the Biosynthesis of Dehydroalanines in Goadsporin

(2016) Taro Ozaki et al.   CHEMBIOCHEM

Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects

(2016) Kozo Ochi   JOURNAL OF ANTIBIOTICS

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products

(2016) Joseph Scott Zarins-Tutt et al.   NATURAL PRODUCT REPORTS

Mapping Microbial Response Metabolomes for Induced Natural Product Discovery

(2015) Dagmara K. Derewacz et al.   ACS Chemical Biology

Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans

(2015) Hiroyasu Onaka et al.   JOURNAL OF ANTIBIOTICS

5-Alkyl-1,2,3,4-tetrahydroquinolines, New Membrane-Interacting Lipophilic Metabolites Produced by Combined Culture of Streptomyces nigrescens and Tsukamurella pulmonis

(2015) Ryosuke Sugiyama et al.   ORGANIC LETTERS

Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium

(2015) Shotaro Hoshino et al.   ORGANIC LETTERS

Killing of Mycolic Acid-Containing Bacteria Aborted Induction of Antibiotic Production by Streptomyces in Combined-Culture

(2015) Shumpei Asamizu et al.   PLoS One

Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis

(2014) Kentaro Haginaka et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery

(2014) Samuel Bertrand et al.   BIOTECHNOLOGY ADVANCES

Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823

(2014) Shotaro Hoshino et al.   JOURNAL OF ANTIBIOTICS

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biosynthetic Origin of Alchivemycin A, a New Polyketide from Streptomyces and Absolute Configuration of Alchivemycin B

(2013) Youngju Kim et al.   ORGANIC LETTERS

Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis inStreptomycesSpecies

(2010) Hiroyasu Onaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton fromStreptomycessp.†

(2010) Yasuhiro Igarashi et al.   ORGANIC LETTERS

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY