Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology

Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia

(2017) Lidia Ruiz-Llorente et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Alk1 controls arterial endothelial cell migration in lumenized vessels

(2016) Elizabeth R. Rochon et al.   DEVELOPMENT

Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia

(2016) Kevin J. Whitehead et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Bevacizumab Nasal Spray on Epistaxis Duration in Hereditary Hemorrhagic Telangectasia

(2016) Sophie Dupuis-Girod et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

(2016) Santiago Ruiz et al.   Scientific Reports

Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension

(2015) Edda Spiekerkoetter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations

(2015) Elizabeth R. Rochon et al.   CARDIOVASCULAR RESEARCH

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis

(2015) Khader Awwad et al.   CARDIOVASCULAR RESEARCH

Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia

(2015) Ferdos Alaa el Din et al.   PLoS One

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Pericytes as targets in hereditary hemorrhagic telangiectasia

(2015) Jérémy Thalgott et al.   Frontiers in Genetics

Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia

(2015) Daniela S. Ardelean et al.   Frontiers in Genetics

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges

(2015) Simon Tual-Chalot et al.   Frontiers in Genetics

Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era

(2015) Jamie McDonald et al.   Frontiers in Genetics

Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report

(2014) Eva M. Garrido-Martin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FOXO1-Mediated Activation of Akt Plays a Critical Role in Vascular Homeostasis

(2014) Harita Dharaneeswaran et al.   CIRCULATION RESEARCH

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

(2014) C. Mallet et al.   HUMAN MOLECULAR GENETICS

Arteries are formed by vein-derived endothelial tip cells

(2014) Cong Xu et al.   Nature Communications

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

(2013) Whitney L. Wooderchak-Donahue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment

(2013) Daniela S. Ardelean et al.   ANGIOGENESIS

Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence

(2013) D. W. Laux et al.   DEVELOPMENT

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

GobyWeb: Simplified Management and Analysis of Gene Expression and DNA Methylation Sequencing Data

(2013) Kevin C. Dorff et al.   PLoS One

Compression of Structured High-Throughput Sequencing Data

(2013) Fabien Campagne et al.   PLoS One

Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development

(2013) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

(2013) Y. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II

(2012) Jai-Hyun Kim et al.   ANGIOGENESIS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

BMP9 regulates endoglin-dependent chemokine responses in endothelial cells

(2012) K. Young et al.   BLOOD

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

BMP signaling in vascular diseases

(2012) Jie Cai et al.   FEBS LETTERS

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

(2012) Laurens A. van Meeteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Dependent Lethality in Novel Transgenic Mouse Models of Central Nervous System Arteriovenous Malformations

(2012) Ian Milton et al.   STROKE

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus

(2011) Sharareh Siamakpour-Reihani et al.   PLoS One

Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations

(2010) N. Ricard et al.   BLOOD

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

(2010) G. A. Strasser et al.   BLOOD

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Update on molecular diagnosis of hereditary hemorrhagic telangiectasia

(2010) Jennifer Richards-Yutz et al.   HUMAN GENETICS

Hereditary hemorrhagic telangiectasia: from molecular biology to patient care

(2010) S. DUPUIS-GIROD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation

(2009) Prodyot K. Chatterjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ALK1 signaling regulates early postnatal lymphatic vessel development

(2009) K. Niessen et al.   BLOOD

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH