Article
Immunology
Jian-nan Hu, Ying Liu, Shu-chang Liu, Teng Zhang, Gui-bing Chen, Jie Zhao, Tao Ma
Summary: This study verified that delayed administration of the selective alpha 7nAChR agonist GTS-21 can effectively eliminate pathogens, reduce inflammatory response and organ injury, and improve survival rates in a model of polymicrobial septic peritonitis. It was found that GTS-21 stimulation enhances the recruitment and antibacterial activity of monocytes, and the benefits of GTS-21 treatment were dependent on the presence of the spleen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bo-Ran Choi, Kory R. Johnson, Dragan Maric, Dorian B. McGavern
Summary: This study investigates how infiltrating monocytes in the central nervous system program resident microglia to mediate angiogenesis and cerebrovascular repair after intracerebral hemorrhage. The researchers identified a subpopulation of microglia, termed 'repair-associated microglia' (RAMs), that express vascular endothelial growth factor A and interleukin-6Ra in stroke brain lesions. Faulty RAM programming was observed without IL-6 signaling, and infiltrating CCR2(+) monocytes were found to be the primary source of IL-6 and necessary for microglia proliferation and proangiogenic properties. Defective RAM programming resulted in poor cerebrovascular repair, neuronal destruction, and sustained neurological deficits, which were all restored with exogenous IL-6 administration.
Article
Pediatrics
Biangchwadaka Suchiang, Manish Pathak, Rahul Saxena, Shailja Sharma, Aliza Mittal, Shubhalaxmi Nayak, Avinash Jadhav, Kirtikumar Rathod, Arvind Sinha
Summary: This study assessed the role of urinary proteins in surgical intervention for hydronephrotic kidney in children. It was found that the levels of urinary proteins were significantly higher in patients with obstructive hydronephrosis compared to those with non-obstructive dilation. The study highlights the potential of urinary proteins as biomarkers for identifying children with hydronephrosis and evaluating the effectiveness of pyeloplasty.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jawed A. Siddiqui, Carole Le Henaff, Joshua Johnson, Zhiming He, Daniel B. Rifkin, Nicola C. Partridge
Summary: The study demonstrates that in bone tissue, MCP-1 is the most highly stimulated gene after PTH stimulation, with osteoblasts being the primary cells expressing MCP-1. The importance of MCP-1 in PTH's anabolic effects is confirmed by experiments showing that MCP-1 null mice do not respond to PTH, and that treatment with MCP-1 peptide can rescue this effect.
Article
Pharmacology & Pharmacy
Haider Jabbar Al Hassani, Wasan Sami Hameed, Ali M. Janabi, Najah R. Hadi
Summary: Diabetes mellitus is the most prevalent metabolic non-communicable disease globally, with diabetic microvascular and macro vascular complications causing significant morbidity and mortality. Chronic elevation of blood glucose levels can lead to thickening and weakening of the basement membrane in blood vessels, causing damage to arteries and small blood vessels, including the kidneys. Elevated levels of MCP-1, IL-1 beta and NGAL have been found in diabetic patients with varying degrees of nephropathy compared to healthy controls, indicating a potential association between these biomarkers and diabetic nephropathy incidence.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Sen Lian, Shinan Li, Jun Zhu, Yong Xia, Young Do Jung
Summary: This study found that nicotine induces IL-8 expression via the ROS/NF-kappa B and ROS/MAPK (Erk1/2, p38)/AP-1 axis in gastric cancer cells, thus stimulating endothelial cell proliferation and angiogenesis in the tumor microenvironment.
Article
Multidisciplinary Sciences
He-Zhou Guo, Zi-Hua Guo, Shan-He Yu, Li-Ting Niu, Wan-Ting Qiang, Meng-Meng Huang, Yuan-Yuan Tian, Juan Chen, Hui Yang, Xiang-Qin Weng, Yi Zhang, Wu Zhang, Shao-Yan Hu, Jun Shi, Jiang Zhu
Summary: Abnormal IL-36 production in leukemic progenitor cells is a key feature of AML, promoting inflammation and preventing leukemia clearance by CD8(+) T cells. Chemotherapy-induced IL-36 production from residual leukemic cells allows for the persistence of an immunosuppressive axis post-treatment. Depletion of inflammatory monocytes, in combination with chemotherapy and PD-1 blockade, shows promise in restricting AML progression and relapse.
Article
Multidisciplinary Sciences
Mao Suzuki, Yasushi Ototake, Asami Akita, Miho Asami, Noriko Ikeda, Tomoya Watanabe, Miwa Kanaoka, Yukie Yamaguchi
Summary: Enhanced levels of periostin in the blood are associated with disease severity in systemic sclerosis (SSc) patients. This study investigated the effect of periostin on immune cells, particularly monocytes and macrophages, in the pathogenesis of SSc.
Article
Biochemistry & Molecular Biology
Chung Kwon Kim, Jeong-Seob Won, Jae Yeol An, Ho Jin Lee, Ah-Jin Nam, Hyun Nam, Ji Yeoun Lee, Kyung-Hoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: Adult human neural stem cells (ahNSCs) can improve motor function and provide neuroprotective effects for spinal cord injury (SCI) patients by inhibiting apoptosis of spinal cord neurons. The conditioned medium (CM) of ahNSCs was found to have paracrine effects through the release of various cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jianqin Lei, Guolong Ding, Anming Xie, Yaguang Hu, Ning Gao, Xiaojuan Fan
Summary: The study found that MCP-1 was a predictor for the unfavorable visual outcome of PDR after IVB pretreatment and PPV.
Article
Multidisciplinary Sciences
Andrea T. Obi, Sriganesh B. Sharma, Megan A. Elfline, Catherine E. Luke, Abigail R. Dowling, Qing Cai, Andrew S. Kimball, Mike Hollinstat, Livia Stanger, Bethany B. Moore, Farouc A. Jaffer, Peter K. Henke
Summary: Deep venous thrombosis and residual thrombus burden are associated with circulating IL-6 levels in humans. By investigating the cellular source and role of IL-6 in thrombus resolution, the study found that IL-6 deficiency impairs thrombus recanalization and resolution. Restoring or augmenting IL-6 signaling in monocytes may improve thrombus resolution.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Tannaz Jamialahmadi, Mitra Abbasifard, Zeljko Reiner, Prashant Kesharwani, Amirhossein Sahebkar
Summary: This meta-analysis found that bariatric surgery significantly decreases MCP-1 concentration, but there was no association between the changes in BMI and absolute difference in MCP-1 levels before and after the surgery. However, a linear relationship between the changes in MCP-1 and length of follow-up was proven.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rehab G. Khalil, Adel Abdel-Moneim, Ahmed I. Yousef, Hanan Abdel-Rahman, Mohamed I. Zanaty, Amr El-Sayed
Summary: The study investigated the role of interleukins in children with T1DM and found a significant increase in IL-21 and IL-23, as well as a decrease in IL-2 levels. These interleukins were associated with dyslipidemia in diabetic children. Therapies targeting IL-21 and IL-23 may be promising for preventing T1DM and its complications.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Hematology
Gonzalo Blanco, Anna Puiggros, Barbara Sherry, Lara Nonell, Xavier Calvo, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, Gerardo Ferrer, Florencia Palacios, Magdalena Arnal, Maria Rodriguez-Rivera, Eva Gimeno, Eugenia Abella, Kanti R. Rai, Pau Abrisqueta, Francesc Bosch, Alexandre Calon, Ana Ferrer, Nicholas Chiorazzi, Blanca Espinet
Summary: Studies have revealed differences in the inflammatory environment between MBL and CLL, highlighting an active role for antigen stimulation in the very early stages of the disease, potentially related to malignant B-cell transformation.
EXPERIMENTAL HEMATOLOGY
(2021)
Article
Oncology
Gerardo Ferrer, Byeongho Jung, Pui Yan Chiu, Rukhsana Aslam, Florencia Palacios, Andrea Nicola Mazzarello, Stefano Vergani, Davide Bagnara, Shih-Shih Chen, Sophia Yancopoulos, Aliki Xochelli, Xiao-Jie Yan, Jan A. Burger, Jacqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kostas Stamatopoulos, Kanti R. Rai, Barbara Sherry, Nicholas Chiorazzi
Summary: MDSCs have an immunomodulatory effect on autologous T lymphocytes, with PMN-MDSCs exhibiting a stronger correlation with different subsets of Th cells in vivo and being more efficient at blocking T-cell growth and promoting Th17 differentiation, while M-MDSCs show varying inhibitory abilities in vitro due to the action of TNF-α.
Article
Medicine, Research & Experimental
Byeongho Jung, Gerardo Ferrer, Pui Yan Chiu, Rukhsana Aslam, Anita Ng, Florencia Palacios, Michael Wysota, Martina Cardillo, Jonathan E. Kolitz, Steven L. Allen, Jacqueline C. Barrientos, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry
Summary: Chronic lymphocytic leukemia (CLL) patients with higher levels of IL-17A(+) and IL-17F(+) CD4(+) T cells and increased expression of miR155 in Th17 cells have better outcomes. CLL cells directly regulate miR155 levels in T cells, thereby affecting Th17 differentiation. CLL cells promote IL-17A(+) and IL-17F(+) T cell generation through an miR155-dependent mechanism. This mechanism is associated with clinical prognosis in CLL.
Article
Surgery
Lyudmyla Demyan, Amber N. Habowski, Dennis Plenker, Daniel A. King, Oliver J. Standring, Caitlin Tsang, Luce St Surin, Arvind Rishi, James M. Crawford, Jeff Boyd, Shamsher A. Pasha, Hardik Patel, Zachary Galluzzo, Christine Metz, Peter K. Gregersen, Sharon Fox, Cristina Valente, Sonya Abadali, Steffi Matadial-Ragoo, Danielle K. DePeralta, Gary B. Deutsch, Joseph M. Herman, Mark A. Talamini, David A. Tuveson, Matthew J. Weiss
Summary: This study evaluated the predictive value of patient-derived organoids (PDOs) in pancreatic adenocarcinoma patients' response to neoadjuvant chemotherapy, showing a correlation between chemotherapy response of PDOs and pathological response, especially to oxaliplatin. The ability to establish PDOs from different tissue sources and ethnic minorities could aid in dynamic chemotherapy sensitivity profiling.
Article
Medicine, General & Internal
Andrew J. Shih, Robert P. Adelson, Himanshu Vashistha, Houman Khalili, Ashima Nayyar, Radha Puran, Rixsi Herrera, Prodyot K. Chatterjee, Annette T. Lee, Alexander M. Truskinovsky, Kristine Elmaliki, Margaret DeFranco, Christine N. Metz, Peter K. Gregersen
Summary: This study found significant differences in endometrial tissues between endometriosis cases and controls. The controls had more proliferating uterine natural killer cells and decidualized endometrial stromal cells, while the cases had more cells expressing inflammatory and senescent phenotypes.
Article
Environmental Sciences
Emily L. Silva, Douglas I. Walker, Zoe Coates Fuentes, Brismar Pinto-Pacheco, Christine N. Metz, Peter K. Gregersen, Shruthi Mahalingaiah
Summary: This study conducted a preliminary untargeted metabolomic analysis of menstrual blood, and identified various environmental chemicals, including suspected reproductive toxicants. The study also found that the endogenous metabolites detected in menstrual blood samples provided good coverage of the human blood metabolome. Therefore, menstrual blood samples have potential applications in exposome research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Meeting Abstract
Hematology
Cristina Paraschivescu, Shivani Chhabra, Rukhsana Aslam, Byeongho Jung, Gerardo Ferrer, Jacqueline C. Barrientos, Joanna M. Rhodes, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Barbara Sherry, Nicholas Chiorazzi
Meeting Abstract
Hematology
Gonzalo Blanco, Florencia Palacios, Kamala Vanarsa, Poojitha Dugyala, Pui Yan Chiu, Steven L. Allen, Yasmine Kieso, Anna Puiggros, Jacqueline C. Barrientos, Xavier Calvo, Jonathan E. Kolitz, Eva Gimeno, Joanna M. Rhodes, Ana Ferrer, Kanti R. Rai, Barbara Sherry, Blanca Espinet, Chandra Mohan, Nicholas Chiorazzi
Article
Biochemistry & Molecular Biology
Ibrahim T. Mughrabi, Mahendar Ochani, Mirza Tanovic, Ping Wang, Betty Diamond, Barbara Sherry, Valentin A. Pavlov, Seza Ozen, Daniel L. Kastner, Jae Jin Chae, Yousef Al-Abed
Summary: This study demonstrated that galantamine attenuates chronic inflammation in a mouse model of familial Mediterranean fever, suggesting its potential therapeutic use in this and other autoinflammatory diseases.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ahmad Altiti, Mingzhu He, Sonya VanPatten, Kai Fan Cheng, Umair Ahmed, Pui Yan Chiu, Ibrahim T. Mughrabi, Bayan Al Jabari, Ronald M. Burch, Kirk R. Manogue, Kevin J. Tracey, Betty Diamond, Christine N. Metz, Huan Yang, LaQueta K. Hudson, Stavros Zanos, Myoungsun Son, Barbara Sherry, Thomas R. Coleman, Yousef Al-Abed
Summary: Peptides, important therapeutic agents, are limited by rapid degradation. The authors developed a method using functionalized thiocarbazate scaffolds to integrate aza-amino acids into peptide sequences, extending their bioavailability. This platform was demonstrated on two well-studied peptides, showing its superiority in peptide optimization.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Deepti Gadi, Stephen P. Martindale, Pui Yan Chiu, Jasneet Khalsa, Pei-Hsuan Chen, Stacey M. Fernandes, Zixu Wang, Svitlana Tyekucheva, John-Hanson Machado, David C. Fisher, Philippe Armand, Matthew S. Davids, Scott Rodig, Barbara Sherry, Jennifer R. Brown
Summary: PI3K delta inhibitors have limited clinical use due to unpredictable autoimmune toxicity, although they have promising efficacy and evidence of improved clinical outcomes. In this study, the effects of idelalisib and duvelisib on T cell differentiation were investigated in vitro, and it was found that both inhibitors inhibited T cell proliferation and Th1 and Treg differentiation while promoting Th2 and Th17 differentiation. In addition, it was demonstrated that autoimmune toxicity in patients was associated with increased numbers of CD4 and CD8 T cells with Th17 differentiation and infiltration of Th17(+) T cells in gastrointestinal tissues. These findings suggest that restoring the balance between Tregs and Th17 cells may be important in preventing autoimmune toxicity.
BLOOD CANCER JOURNAL
(2023)
Article
Multidisciplinary Sciences
Caterina Ivaldo, Mario Passalacqua, Anna Lisa Furfaro, Cristina d'Abramo, Santiago Ruiz, Prodyot K. Chatterjee, Christine N. Metz, Mariapaola Nitti, Philippe Marambaud
Summary: Oxidative stress induced efficient proteolysis of VE-cadherin by MMPs and gamma-secretase in HUVECs. The cytoplasmic domain of VE-cadherin produced by gamma-secretase, VE-Cad/CTF2, was tightly regulated and sequentially produced from an ADAM10/17-generated C-terminal fragment. BMP9 and BMP10 reduced VE-Cad/CTF2 levels and mitigated H2O2-mediated actin cytoskeleton disassembly.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
David Hutton, Aida Mustafa, Soha Patil, Saira Rathod, Gautam Shrikhande, Arnold Advincula, Jessica Drummond, Peter Gregersen, Jason Hall, Christine Metz, Alexandra Milspaw, Iris Kerin Orbuch, Peter Stahl, Amy Stein, Allyson Shrikhande
Summary: This article examines the healthcare utilization, cost burden, and quality-of-life restrictions experienced by patients with Chronic Pelvic Pain (CPP). It analyzes data from new patient visit progress notes and the FAIR Health Consumer online database, revealing a significant cost burden for CPP patients in terms of surgeries, diagnostics, and treatments.
Article
Immunology
Tengfei Song, Yonghong Yao, Julien Papoin, Barbara Sherry, Betty Diamond, Hua Gu, Lionel Blanc, Yong-Rui Zou
Summary: Infection can enhance myeloid output even after it is cleared, and TIMP1 plays a role in sustaining this effect by suppressing the activation of the Notch signaling pathway.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)