FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6

(2012) Yonggang Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sildenafil Potentiates Bone Morphogenetic Protein Signaling in Pulmonary Arterial Smooth Muscle Cells and in Experimental Pulmonary Hypertension

(2012) Jun Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH

(2012) Md Talat Nasim et al.   HUMAN MOLECULAR GENETICS

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

(2012) Apirat Chaikuad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

(2012) Jongmin Kim et al.   NATURE MEDICINE

BMPR2 expression is suppressed by signaling through the estrogen receptor

(2012) Eric D Austin et al.   Biology of Sex Differences

Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

(2011) Suparna M. Chandra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Suppression of EGFR Autophosphorylation by FKBP12

(2011) Sebastian Mathea et al.   BIOCHEMISTRY

Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension

(2011) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

(2011) Tero-Pekka Alastalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunosuppressor FK506 Increases Endoglin and Activin Receptor-Like Kinase 1 Expression and Modulates Transforming Growth Factor- 1 Signaling in Endothelial Cells

(2011) V. Albinana et al.   MOLECULAR PHARMACOLOGY

Small-molecule displacement of a cryptic degron causes conditional protein degradation

(2011) Kimberly M Bonger et al.   Nature Chemical Biology

Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators

(2011) P. Owens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Creating Diverse Target-Binding Surfaces on FKBP12: Synthesis and Evaluation of a Rapamycin Analogue Library

(2011) Xianghong Wu et al.   ACS Combinatorial Science

Somatic Chromosome Abnormalities in the Lungs of Patients with Pulmonary Arterial Hypertension

(2010) Micheala A. Aldred et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Apelin Is a Crucial Factor for Hypoxia-Induced Retinal Angiogenesis

(2010) Atsushi Kasai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Smad-Dependent and Smad-Independent Induction of Id1 by Prostacyclin Analogues Inhibits Proliferation of Pulmonary Artery Smooth Muscle Cells In Vitro and In Vivo

(2010) Jun Yang et al.   CIRCULATION RESEARCH

Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death

(2010) Giovanni Passiatore et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Complications With Recombinant Human Bone Morphogenic Protein-2 in Posterolateral Spine Fusion

(2010) Steven D. Glassman et al.   SPINE

Low- but not high-dose FK506 treatment confers atheroprotection due to alternative macrophage activation and unaffected cholesterol levels

(2010) Erwin Wijnands et al.   THROMBOSIS AND HAEMOSTASIS

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4

(2009) Edda Spiekerkoetter et al.   CIRCULATION RESEARCH

Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway

(2009) Matthias Brock et al.   CIRCULATION RESEARCH

Penetrance of pulmonary arterial hypertension is modulated by the expression of normalBMPR2allele

(2009) Rizwan Hamid et al.   HUMAN MUTATION

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways

(2009) Vinicio A. de Jesus Perez et al.   JOURNAL OF CELL BIOLOGY

The Transforming Growth Factor-β Type III Receptor Mediates Distinct Subcellular Trafficking and Downstream Signaling of Activin-like Kinase (ALK)3 and ALK6 Receptors

(2009) Nam Y. Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Mutations in Bone Morphogenetic Protein Type II Receptor Cause Dysregulation of Id Gene Expression in Pulmonary Artery Smooth Muscle Cells

(2008) Jun Yang et al.   CIRCULATION RESEARCH

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

(2008) Hyung J. Chun et al.   JOURNAL OF CLINICAL INVESTIGATION

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

(2008) Georg Hansmann et al.   JOURNAL OF CLINICAL INVESTIGATION

FKBP Family Proteins: Immunophilins with Versatile Biological Functions

(2008) Cong Bao Kang et al.   NEUROSIGNALS

In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure

(2007) Ahmad Y. Sheikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY