标题
Pseudokinases: update on their functions and evaluation as new drug targets
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 9, Issue 2, Pages 245-265
出版商
Future Science, LTD
发表日期
2017-01-18
DOI
10.4155/fmc-2016-0207
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors
- (2016) Sijin Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 C helix
- (2016) E. Leroy et al. BIOCHEMICAL JOURNAL
- The evolving world of pseudoenzymes: proteins, prejudice and zombies
- (2016) Patrick A. Eyers et al. BMC BIOLOGY
- (WNK)ing at death: With-no-lysine (Wnk) kinases in neuropathies and neuronal survival
- (2016) Bor Luen Tang BRAIN RESEARCH BULLETIN
- Targeting biomolecules with reversible covalent chemistry
- (2016) Anupam Bandyopadhyay et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Stapled peptides: providing the best of both worlds in drug development
- (2016) Xiayang Xie et al. Future Medicinal Chemistry
- Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial
- (2016) S. Verstovsek et al. HAEMATOLOGICA
- The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
- (2016) Silvia Alvarez-Diaz et al. IMMUNITY
- Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3
- (2016) Alvin Kung et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- KinView: a visual comparative sequence analysis tool for integrated kinome research
- (2016) Daniel Ian McSkimming et al. Molecular BioSystems
- Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling
- (2016) Neil S. Dhawan et al. NATURE
- Overcoming resistance to HER2 inhibitors through state-specific kinase binding
- (2016) Chris J Novotny et al. Nature Chemical Biology
- Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia
- (2016) John C. Byrd et al. NEW ENGLAND JOURNAL OF MEDICINE
- ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis
- (2016) Bin Ma et al. PLoS One
- Structural Basis for the Non-catalytic Functions of Protein Kinases
- (2016) Jennifer E. Kung et al. STRUCTURE
- Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial
- (2016) S. Verstovsek et al. HAEMATOLOGICA
- The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner
- (2015) Fiona P. Bailey et al. BIOCHEMICAL JOURNAL
- Going for broke: targeting the human cancer pseudokinome
- (2015) Fiona P. Bailey et al. BIOCHEMICAL JOURNAL
- Tribbles pseudokinases: novel targets for chemical biology and drug discovery?
- (2015) D. M. Foulkes et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The role of TRIB1 in lipid metabolism; from genetics to pathways
- (2015) S. Iwamoto et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Tribbles in inflammation
- (2015) J. Johnston et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Nucleotide-binding mechanisms in pseudokinases
- (2015) H. M. Hammaren et al. BIOSCIENCE REPORTS
- Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)
- (2015) Xiaoshan Min et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain
- (2015) John S. Tokarski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis
- (2015) Jonathan A. Stefely et al. MOLECULAR CELL
- ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
- (2015) Henrik M. Hammarén et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase
- (2015) James M. Murphy et al. STRUCTURE
- First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway
- (2015) M. Hagel et al. Cancer Discovery
- Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol
- (2015) Eric R. Goedken et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides
- (2014) Yuxiao Wang et al. ACS Chemical Biology
- The molecular regulation of Janus kinase (JAK) activation
- (2014) Jeffrey J. Babon et al. BIOCHEMICAL JOURNAL
- ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
- (2014) Carlos L. Arteaga et al. CANCER CELL
- Drugging MYCN through an Allosteric Transition in Aurora Kinase A
- (2014) William Clay Gustafson et al. CANCER CELL
- RETRACTED: An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
- (2014) Peter Littlefield et al. CHEMISTRY & BIOLOGY
- Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases
- (2014) Sandra W Cowan-Jacob et al. Future Medicinal Chemistry
- MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance
- (2014) Richard Ottman et al. Molecular Cancer
- WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
- (2014) Wen Zhu et al. Molecular Cancer
- Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity
- (2014) Hao Huang et al. MOLECULAR CELL
- Mass-spectrometry-based draft of the human proteome
- (2014) Mathias Wilhelm et al. NATURE
- Pharmacological targeting of the pseudokinase Her3
- (2014) Ting Xie et al. Nature Chemical Biology
- A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
- (2014) Bryan R Lanning et al. Nature Chemical Biology
- Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
- (2014) Joanne M. Hildebrand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
- (2014) Y. Han et al. SCIENCE
- Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations
- (2014) P. Littlefield et al. Science Signaling
- Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation
- (2014) A. T. Piala et al. Science Signaling
- A Plug Release Mechanism for Membrane Permeation by MLKL
- (2014) Lijing Su et al. STRUCTURE
- Day of the dead: pseudokinases and pseudophosphatases in physiology and disease
- (2014) Veronika Reiterer et al. TRENDS IN CELL BIOLOGY
- Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line
- (2014) J. Bogomolovas et al. Open Biology
- Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor
- (2013) Agustin H. Mohedas et al. ACS Chemical Biology
- Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses
- (2013) Leila N. Varghese et al. BIOCHEMICAL JOURNAL
- Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
- (2013) James M. Murphy et al. BIOCHEMICAL JOURNAL
- A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
- (2013) James M. Murphy et al. BIOCHEMICAL JOURNAL
- The functionally diverse roles of tribbles
- (2013) Fiona Lohan et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The dual function of KSR1: a pseudokinase and beyond: Figure 1
- (2013) Hua Zhang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Pseudokinase drug intervention: a potentially poisoned chalice
- (2013) Jeroen Claus et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Pseudokinases from a structural perspective
- (2013) Susan S. Taylor et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Dawn of the dead: protein pseudokinases signal new adventures in cell biology
- (2013) Patrick A. Eyers et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Drug discovery considerations in the development of covalent inhibitors
- (2013) Robert Mah et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
- (2013) J. A. Dubovsky et al. BLOOD
- Oncogenic ERBB3 Mutations in Human Cancers
- (2013) Bijay S. Jaiswal et al. CANCER CELL
- An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
- (2013) A. P. Garner et al. CANCER RESEARCH
- KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
- (2013) Laura R. Pearce et al. CELL
- Developing Irreversible Inhibitors of the Protein Kinase Cysteinome
- (2013) Qingsong Liu et al. CHEMISTRY & BIOLOGY
- TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway
- (2013) W. Zhang et al. DIABETES
- The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
- (2013) James M. Murphy et al. IMMUNITY
- TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function
- (2013) Jiayi Wang et al. MOLECULAR CELL
- Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins
- (2013) Mary Christie et al. MOLECULAR CELL
- New kinase targets for Alzheimer's disease
- (2013) Monica Hoyos Flight NATURE REVIEWS DRUG DISCOVERY
- Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
- (2013) Angela V Toms et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
- (2013) Michael L. Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
- (2013) John C. Byrd et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structural Insights into RIP3-Mediated Necroptotic Signaling
- (2013) Tian Xie et al. Cell Reports
- Ibrutinib (PCI-32765), the First BTK (Bruton’s Tyrosine Kinase) Inhibitor in Clinical Trials
- (2013) Jennifer R. Brown Current Hematologic Malignancy Reports
- Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family
- (2012) Stephen C. Artim et al. BIOCHEMICAL JOURNAL
- Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia
- (2012) T. Yokoyama et al. BLOOD
- HER3 Is Required for HER2-Induced Preneoplastic Changes to the Breast Epithelium and Tumor Formation
- (2012) D. B. Vaught et al. CANCER RESEARCH
- Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
- (2012) S. Huang et al. CANCER RESEARCH
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- Discovery of Potent and Selective Covalent Inhibitors of JNK
- (2012) Tinghu Zhang et al. CHEMISTRY & BIOLOGY
- Ruxolitinib: The First FDA Approved Therapy for the Treatment of Myelofibrosis
- (2012) J. Mascarenhas et al. CLINICAL CANCER RESEARCH
- Irreversible Protein Kinase Inhibitors: Balancing the Benefits and Risks
- (2012) Tjeerd Barf et al. JOURNAL OF MEDICINAL CHEMISTRY
- Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
- (2012) Rajintha M Bandaranayake et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- JAK/STAT signaling in hematological malignancies
- (2012) W Vainchenker et al. ONCOGENE
- With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume
- (2011) Brian R. Haas et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation
- (2011) Takashi Yokoyama et al. CANCER SCIENCE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors
- (2011) Emeline Leproult et al. JOURNAL OF MEDICINAL CHEMISTRY
- Irreversible Nek2 Kinase Inhibitors with Cellular Activity
- (2011) Jeffrey C. Henise et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
- (2011) Damian F. Brennan et al. NATURE
- Comprehensive analysis of kinase inhibitor selectivity
- (2011) Mindy I Davis et al. NATURE BIOTECHNOLOGY
- The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
- (2011) Daniela Ungureanu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα
- (2011) K B Grandinetti et al. ONCOGENE
- The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology
- (2011) Gerard Manning et al. GENOME BIOLOGY
- Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design
- (2010) Charlotte A. Dodson et al. BIOCHEMICAL JOURNAL
- A Structure-Guided Approach to Creating Covalent FGFR Inhibitors
- (2010) Wenjun Zhou et al. CHEMISTRY & BIOLOGY
- KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1
- (2010) Jeremy A. Goettel et al. EXPERIMENTAL CELL RESEARCH
- Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
- (2010) Jianming Zhang et al. NATURE
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- Molecular mechanisms of necroptosis: an ordered cellular explosion
- (2010) Peter Vandenabeele et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells
- (2010) F Zanella et al. ONCOGENE
- JAK2 V617F Constitutive Activation Requires JH2 Residue F595: A Pseudokinase Domain Target for Specific Inhibitors
- (2010) Alexandra Dusa et al. PLoS One
- Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
- (2010) Wen-I Wu et al. PLoS One
- ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
- (2010) Fumin Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
- (2010) L. A. Honigberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evolution of CASK into a Mg2+-Sensitive Kinase
- (2010) K. Mukherjee et al. Science Signaling
- The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics
- (2010) Dhara N. Amin et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Kinase suppressor of Ras transphosphorylates c-Raf-1
- (2009) Mohammad Zafrullah et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions
- (2009) Koichi Fukuda et al. MOLECULAR CELL
- Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
- (2009) N. Jura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation
- (2009) E. Zeqiraj et al. SCIENCE
- Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
- (2009) Eric D. Scheeff et al. STRUCTURE
- ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
- (2009) Elton Zeqiraj et al. PLOS BIOLOGY
- Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
- (2008) Xu Huang et al. BIOCHEMICAL JOURNAL
- The ERBB3 receptor in cancer and cancer gene therapy
- (2008) G Sithanandam et al. CANCER GENE THERAPY
- CASK Functions as a Mg2+-Independent Neurexin Kinase
- (2008) Konark Mukherjee et al. CELL
- WNK2 modulates MEK1 activity through the Rho GTPase pathway
- (2008) Sónia Moniz et al. CELLULAR SIGNALLING
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