Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Techniques to examine nucleotide binding by pseudokinases: Table 1

(2013) Isabelle S. Lucet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of Janus kinases by SOCS proteins

(2013) Nadia J. Kershaw et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dawn of the dead: protein pseudokinases signal new adventures in cell biology

(2013) Patrick A. Eyers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

(2013) Hao Zhou et al.   EMBO JOURNAL

Pseudokiller, Qu’est-ce que C’est?

(2013) Douglas R. Green   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

A low-background-intensity focusing small-angle X-ray scattering undulator beamline

(2013) Nigel M. Kirby et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins

(2013) Mary Christie et al.   MOLECULAR CELL

Structural Insights into RIP3-Mediated Necroptotic Signaling

(2013) Tian Xie et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

Characterisation of the First Enzymes Committed to Lysine Biosynthesis in Arabidopsis thaliana

(2012) Michael D. W. Griffin et al.   PLoS One

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

(2011) Daniela Ungureanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity

(2009) James M. Murphy et al.   GROWTH FACTORS

Structure and functional characterization of the atypical human kinase haspin

(2009) J. Eswaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

(2009) Eric D. Scheeff et al.   STRUCTURE

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

(2009) Elton Zeqiraj et al.   PLOS BIOLOGY

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY