标题
Targeting LRRK2 in Parkinson’s disease: an update on recent developments
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 21, Issue 6, Pages 601-610
出版商
Informa UK Limited
发表日期
2017-04-26
DOI
10.1080/14728222.2017.1323881
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
- (2016) Chung-Han Hsieh et al. Cell Stem Cell
- Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
- (2016) Rakel López de Maturana et al. Journal of Neuroinflammation
- Inflammatory profile in LRRK2-associated prodromal and clinical PD
- (2016) Kathrin Brockmann et al. Journal of Neuroinflammation
- LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- Targeting the cannabinoid CB 2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice
- (2016) Cristina Palomo-Garo et al. PHARMACOLOGICAL RESEARCH
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2
- (2016) Dario C. Angeles et al. Annals of Clinical and Translational Neurology
- Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy
- (2016) Sangwook Park et al. PLoS One
- Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
- (2016) E. Lobbestael et al. Scientific Reports
- mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
- (2016) Claudia Manzoni et al. Scientific Reports
- Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease
- (2015) Pilar Rivero-Ríos et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5
- (2015) Mary R. Shanley et al. BIOCHEMISTRY
- Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate
- (2015) Petranka Krumova et al. FASEB JOURNAL
- The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins
- (2015) Mark S. Moehle et al. HUMAN MOLECULAR GENETICS
- I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway
- (2015) Etsuro Ohta et al. HUMAN MOLECULAR GENETICS
- Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
- (2015) João P. L. Daher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain
- (2015) Laura Civiero et al. JOURNAL OF NEUROCHEMISTRY
- Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
- (2015) Isabella Russo et al. Journal of Neuroinflammation
- Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2
- (2015) Matthew Hamm et al. JOURNAL OF NEUROSCIENCE RESEARCH
- LRRK2 Promotes Tau Accumulation, Aggregation and Release
- (2015) Patrícia Silva Guerreiro et al. MOLECULAR NEUROBIOLOGY
- Linking a genome-wide association study signal to aLRRK2coding variant in Parkinson's disease
- (2015) Jia Nee Foo et al. MOVEMENT DISORDERS
- Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease
- (2015) Elpida Tsika et al. NEUROBIOLOGY OF DISEASE
- Greater motor progression in patients with Parkinson disease who carryLRRK2risk variants
- (2015) Linda P. Oosterveld et al. NEUROLOGY
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor
- (2015) John M. Hatcher et al. ACS Medicinal Chemistry Letters
- LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
- (2015) Insup Choi et al. Nature Communications
- Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson’s Disease
- (2015) Prakash M. Kumar et al. Scientific Reports
- Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S Mutation
- (2015) Andrew J. Schwab et al. Stem Cell Reports
- Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila
- (2014) D. C. Angeles et al. HUMAN MOLECULAR GENETICS
- Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
- (2014) J. Schapansky et al. HUMAN MOLECULAR GENETICS
- Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor
- (2014) Jaclyn L. Henderson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages
- (2014) Martin Kuss et al. JOURNAL OF NEUROCHEMISTRY
- Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies
- (2014) G. Skibinski et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model
- (2014) S Yang et al. Cell Death & Disease
- Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
- (2014) Vinay K. Godena et al. Nature Communications
- Targeting leucine-rich repeat kinase 2 in Parkinson's disease
- (2013) Sharon L Chan et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
- (2013) Yu-Chin Su et al. HUMAN MOLECULAR GENETICS
- Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
- (2013) Klodjan Stafa et al. HUMAN MOLECULAR GENETICS
- A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation
- (2013) Bernard M. H. Law et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
- (2013) Anthony A. Estrada et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
- (2013) Gregory C. Luerman et al. JOURNAL OF NEUROCHEMISTRY
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
- (2013) Laurie H. Sanders et al. NEUROBIOLOGY OF DISEASE
- RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
- (2013) David A. MacLeod et al. NEURON
- Genetic testing of LRRK2 in Parkinson's disease: is there a clinical role?
- (2013) Donna Mae Lyn Buhat et al. PARKINSONISM & RELATED DISORDERS
- Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
- (2013) Daniel Ness et al. PLoS One
- Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
- (2013) Marco A. S. Baptista et al. PLoS One
- GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
- (2012) Alastair D. Reith et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Characterization of TAE684 as a potent LRRK2 kinase inhibitor
- (2012) Jinwei Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors
- (2012) Dong Wook Han et al. Cell Stem Cell
- Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells
- (2012) Marc Thier et al. Cell Stem Cell
- LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
- (2012) X. Wang et al. HUMAN MOLECULAR GENETICS
- Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
- (2012) Anthony A. Estrada et al. JOURNAL OF MEDICINAL CHEMISTRY
- Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
- (2012) Jingwen Niu et al. JOURNAL OF NEUROCHEMISTRY
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of -Synuclein and LRRK2 in the Brain
- (2012) L. G. Friedman et al. JOURNAL OF NEUROSCIENCE
- LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
- (2012) Kelly M Hinkle et al. Molecular Neurodegeneration
- Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
- (2012) Guang-Hui Liu et al. NATURE
- Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
- (2012) F. Gillardon et al. NEUROSCIENCE
- LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
- (2012) Fumitaka Kawakami et al. PLoS One
- The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
- (2012) Nicolas Dzamko et al. PLoS One
- Mitochondrial Fission, Fusion, and Stress
- (2012) R. J. Youle et al. SCIENCE
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
- (2012) O. Cooper et al. Science Translational Medicine
- Brain Penetrant LRRK2 Inhibitor
- (2012) Hwan Geun Choi et al. ACS Medicinal Chemistry Letters
- Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons
- (2011) Nigel Ramsden et al. ACS Chemical Biology
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition
- (2011) Elizabeth A. Doggett et al. JOURNAL OF NEUROCHEMISTRY
- A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
- (2011) J. Dusonchet et al. JOURNAL OF NEUROSCIENCE
- Rare and common LRRK2 exonic variants in Parkinson's disease
- (2011) Eng-King Tan LANCET NEUROLOGY
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Use of viral vectors to create animal models for Parkinson's disease
- (2011) Karin Löw et al. NEUROBIOLOGY OF DISEASE
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
- (2010) Nicolas Dzamko et al. BIOCHEMICAL JOURNAL
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
- (2010) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
- (2009) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- A chemical platform for improved induction of human iPSCs
- (2009) Tongxiang Lin et al. NATURE METHODS
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- Molecular biology changes associated with LRRK2 mutations in Parkinson's disease
- (2008) Yi Wei Lu et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
- (2008) K. Haugarvoll et al. NEUROLOGY
- Induced Pluripotent Stem Cells Generated Without Viral Integration
- (2008) M. Stadtfeld et al. SCIENCE
- Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
- (2008) K. Okita et al. SCIENCE
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