Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor

The Insulin Receptor/Insulin-Like Growth Factor Receptor Family as a Therapeutic Target in Oncology

(2012) M. Pollak   CLINICAL CANCER RESEARCH

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

(2012) P. Tibarewal et al.   Science Signaling

PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development

(2012) Itay Nakdimon et al.   PLoS Genetics

The Caenorhabditis elegans Eph Receptor Activates NCK and N-WASP, and Inhibits Ena/VASP to Regulate Growth Cone Dynamics during Axon Guidance

(2012) Ahmed M. Mohamed et al.   PLoS Genetics

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

(2011) Adam Naguib et al.   BMC CANCER

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Molecular mechanism of size control in development and human diseases

(2011) Xiaolong Yang et al.   CELL RESEARCH

A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development

(2011) R. Christensen et al.   DEVELOPMENT

Insulin receptor and cancer

(2011) A. Belfiore et al.   ENDOCRINE-RELATED CANCER

Minireview: IGF, Insulin, and Cancer

(2011) Emily J. Gallagher et al.   ENDOCRINOLOGY

A pathway that links reproductive status to lifespan in Caenorhabditis elegans

(2010) Cynthia Kenyon   Annals of the New York Academy of Sciences

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation

(2010) H Zhang et al.   ONCOGENE

Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function

(2009) Eun-Kyoung Yim et al.   CANCER CELL

A Role for C. elegans Eph RTK Signaling in PTEN Regulation

(2009) Sarah Brisbin et al.   DEVELOPMENTAL CELL

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor

(2008) D. S. Patel et al.   GENETICS

Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans

(2008) Roger Pocock et al.   NATURE NEUROSCIENCE

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE