How insulin engages its primary binding site on the insulin receptor

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

(2012) Colin W Ward et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

(2012) J. Whittaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolving Some Old Problems in Protein Crystallography

(2012) P. Evans   SCIENCE

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

(2010) J. Jiracek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray structure determination at low resolution

(2009) Axel T. Brunger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Thermodynamic Study of Ligand Binding to the First Three Domains of the Human Insulin Receptor: Relationship between the Receptor α-Chain C-Terminal Peptide and the Site 1 Insulin Mimetic Peptides

(2009) John G. Menting et al.   BIOCHEMISTRY

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

Enhancing the Activity of a Protein by Stereospecific Unfolding

(2009) Qing-xin Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning

(2009) Bin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation

(2009) Vladislav V Kiselyov et al.   Molecular Systems Biology

Insulin Analogues with Modifications at Position B26. Divergence of Binding Affinity and Biological Activity†

(2008) Lenka Žáková et al.   BIOCHEMISTRY

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

N-linked glycans of the human insulin receptor and their distribution over the crystal structure

(2007) Lindsay G. Sparrow et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS