Review
Immunology
Ali Hazrati, Kosar Malekpour, Zahra Mirsanei, Arezou Khosrojerdi, Nasim Rahmani-Kukia, Neda Heidari, Ardeshir Abbasi, Sara Soudi
Summary: Cancer-associated mesenchymal stem/stromal cells (CA-MSCs) play a crucial role in tumor growth, immune evasion, metastasis, drug resistance, and angiogenesis by interacting with tumor and non-tumor cells in the tumor microenvironment. These cells affect the function of tumor cells and non-tumor cells through the production of cytokines, chemokines, and growth factors. Understanding these interactions is essential for targeted tumor therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Maheedhara R. Guda, Andrew J. Tsung, Swapna Asuthkar, Kiran K. Velpula
Summary: Galectin 1 (Gal-1) plays a crucial role in cancer, and its expression is associated with tumor aggressiveness and progression. Gal-1 promotes the growth of glioma stem cells (GSC) through the Warburg effect. Depletion of Gal-1 leads to reduced lactate levels and increased expression of enzymes from the TCA cycle, indicating a reversal of the Warburg phenotype. Gal-1 regulates the expression of carbonic anhydrase IX (CA-IX) to exert its metabolic role.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Suwen Bai, Zunyun Wang, Minghua Wang, Junai Li, Yuan Wei, Ruihuan Xu, Juan Du
Summary: Tumor-derived exosomes play a critical role in tumor metastasis by transporting proteins and RNA, promoting migration, and influencing interactions with normal cells like vascular endothelial cells and immune cells. Their function in facilitating tumor metastasis underlines the importance of further research in this area.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ana Bogut, Bojan Stojanovic, Marina Jovanovic, Milica Dimitrijevic Stojanovic, Nevena Gajovic, Bojana S. Stojanovic, Goran Balovic, Milan Jovanovic, Aleksandar Lazovic, Milos Mirovic, Milena Jurisevic, Ivan Jovanovic, Violeta Mladenovic
Summary: This review provides a comprehensive overview of the multifaceted role of Galectin-1 in Pancreatic Ductal Adenocarcinoma (PDAC), including its contributions to tumor stroma remodeling, angiogenesis, metabolic reprogramming, and potential implications for therapeutic interventions. The challenges associated with targeting Galectin-1 are discussed, and the promising prospects of Gal-1 inhibition, including the utilization of nanotechnology and theranostics, are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Myrofora Panagi, Pampina Pilavaki, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Summary: Sarcomas are rare malignancies that can arise throughout the human lifespan. Surgery is the best treatment option, while traditional treatments like chemotherapy and radiation have limited effectiveness. Immunotherapy has emerged as a novel approach, but its efficacy in sarcomas is limited by the tumor microenvironment. Understanding the immunological properties of the sarcoma microenvironment and their impact on immunotherapy can help overcome these barriers.
Article
Oncology
Mei-Tzu Su, Sakiko Kumata, Shota Endo, Yoshinori Okada, Toshiyuki Takai
Summary: The study reveals that myeloid-derived suppressor cells (MDSCs) facilitate tumor metastasis and invasion by regulating their polarization and suppressing the secretion of miRNAs.
Article
Nanoscience & Nanotechnology
Chia-Hao Huang, Kowit-Yu Chong, Kin Fong Lei
Summary: The research successfully reproduced an internal hypoxic environment in a paper-based solid tumor, demonstrating high levels of HIF1-alpha and VEGFA expression in the inner layer cells. This induced proliferation and migration of endothelial cells in the internal hypoxic environment. Additionally, the paper-based solid tumor was transplanted into nude mice for the study of hypoxic response and angiogenesis, providing a method for analyzing the interaction between cancer cells, hypoxia, and peripheral angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Immunology
Luxia Chen, Mohamad Alabdullah, Karsten Mahnke
Summary: Adenosine is an immunosuppressive agent produced during inflammation, which can promote tissue healing. However, in chronic inflammation, the anti-inflammatory actions of adenosine may sustain the inflammation and prevent tissue clearance, leading to an increased risk of tumor formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yu-Yi Ling, Ya-Jie Kong, Liang Hao, Zheng-Yin Pan, Zong-Wan Mao, Cai-Ping Tan
Summary: In this study, three Ir(iii) photosensitizers (Ir1-Ir3) targeting carbonic anhydrase IX (CAIX) were designed, and they exhibited potent antiproliferative activities in colon cancer cells upon irradiation with visible light (425 nm). The most active complex Ir3 can photodegrade CAIX under hypoxia, downregulating the expression of HIF-1a and VEGF to improve cancer immune microenvironments. Furthermore, Ir3 can induce pyroptosis of cancer cells through lipid peroxidation, causing immunogenic cell death (ICD) under hypoxia.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Oncology
Elie Marcheteau, Thomas Farge, Michael Peres, Guillaume Labrousse, Julie Tenet, Stephanie Delmas, Maud Chusseau, Raphaelle Duprez-Paumier, Camille Franchet, Florence Dalenc, Caroline Imbert, Justine Noujarede, Celine Colacios, Herve Prats, Florence Cabon, Bruno Segui
Summary: TSP1 plays a crucial role in TNBC by influencing TILs content and immunotherapy efficacy, making it a potential therapeutic target in combination with immunotherapy for TNBC treatment.
Review
Biochemistry & Molecular Biology
Maliha Tabassum Munir, Matthew K. Kay, Min H. Kang, Md Mizanur Rahman, Ahmed Al-Harrasi, Mahua Choudhury, Naima Moustaid-Moussa, Fazle Hussain, Shaikh Mizanoor Rahman
Summary: Breast cancer is the most common cancer in women in Western countries, with TAMs playing a key role in the breast cancer microenvironment and high TAM density being associated with poor prognosis. Altering TAM function may be a potential therapeutic target for treating breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Valeria Manuelli, Chiara Pecorari, Giuseppe Filomeni, Ester Zito
Summary: This review provides an overview of the redox-sensitive steps in angiogenic signaling, the main molecular players involved, and their crosstalk with the unfolded protein response. New classes of inhibitors of these modulators which might act as antiangiogenic drugs in cancer are also discussed.
Review
Medicine, General & Internal
Sonia Santander Ballestin, Andrea Lanuza Bardaji, Cristina Marco Continente, Maria Jose Luesma Bartolome
Summary: The stress response and immunosuppression caused by surgical aggression and anesthetic agents can lead to inadvertent dispersion and progression of tumors. Inhaled anesthetics and opioids have been found to benefit immunosuppression, cell proliferation, and angiogenesis, creating an ideal environment for tumor progression. However, the potential benefits of reducing their use and exploring alternative anesthetic techniques to protect patients from metastasis are still being investigated.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Physical
Guijie Wei, Jianhua Chen, Ziqi Jing, Yanyi Li, Zhihui Li, Wei Zheng, Xiurui Sun, Wenwen Zhao, Zhe Zhang, Xue Wang, Hongcui Han, Chu Li, Yujie Zhang, Pengkai Ma
Summary: The study constructed a glycosylated poly(amido amine)/celastrol complex for hypoxia-activated mitochondria-specific drug delivery and chemothermal therapy in cancer treatment. The complex exhibited high efficiency in killing tumor cells and inhibiting tumor growth with low systemic toxicity.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Cell Biology
Shalini Mani, Geeta Swargiary, Stephen J. Ralph
Summary: Changes in reactive oxygen species levels have significant impacts on cell behavior, especially during carcinogenesis. Cancer cells enhance antioxidative capacity to regulate ROS levels for growth promotion, while anticancer therapies aim to selectively destroy cancer cells by impacting ROS levels and triggering different mechanisms.
Article
Biochemistry & Molecular Biology
Maria Raics, Alex Kalman Balogh, Chandan Kishor, Istvan Timari, Francisco J. Medrano, Antonio Romero, Rob Marc Go, Helen Blanchard, Laszlo Szilagyi, Katalin E. Kover, Krisztina Feher
Summary: In this study, the binding affinities of two selenium-containing hGal-3 inhibitors to hGal-3 were investigated using NMR spectroscopy and fluorescence anisotropy titrations. The results showed that these derivatives bind to hGal-3 at a specific site, but with weaker interaction strength.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Khuchtumur Bum-Erdene, Patrick M. Collins, Matthew W. Hugo, Somayeh S. Tarighat, Fei Fei, Chandan Kishor, Hakon Leffler, Ulf J. Nilsson, John Groffen, I. Darren Grice, Nora Heisterkamp, Helen Blanchard
Summary: In this study, novel Galectin-3 antagonists with enhanced affinity and selectivity were designed and synthesized. Experimental results demonstrated the specific inhibition of Galectin-3-induced BCP-ALL cell agglutination and decreased viability of ALL cells. Therefore, these compounds show promise as important leads for cancer therapeutics.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Xiangling Xing, Ninni Mu, Xiaotian Yuan, Na Wang, C. Christofer Juhlin, Klas Straat, Catharina Larsson, Shi Yong Neo, Dawei Xu
Summary: GABPB1 plays an oncogenic role in activating TERT gene expression, but also has tumor-suppressive functions in thyroid cancer. Targeting GABPB1 for cancer therapy should be cautious.
Article
Chemistry, Organic
Peter Sunde-Brown, Ian D. Jenkins, Helen Blanchard, Todd A. Houston
Summary: Methyl a(and b)-D-3,4-anhydro-tagatofuranosides are important synthetic building blocks that can undergo regioselective ring-opening to yield products with the D-fructo configuration. A modified Mitsunobu protocol with the addition of phenol allows for the exclusive and quantitative formation of tagato products under mild conditions. This reaction mechanism involves the intermediate formation of diphenoxytriphenylphosphorane, which acts as a selective Mitsunobu reagent. An unusual Mitsunobu-induced anomerisation reaction is also observed.
Meeting Abstract
Oncology
X. Chen, E. G. Sifakis, S. Robertson, S. Y. Neo, S-H. Jun, L. Tong, J. Lovrot, A. Tay, R. Hellgren, S. Margolin, J. Bergh, T. Foukakis, J. Lagergren, A. Lundqvist, R. Ma, J. Hartman
ANNALS OF ONCOLOGY
(2022)
Review
Oncology
Stephen John Ralph, Maxwell J. Reynolds
Summary: Neutrophils have potential in fighting against cancer. Activation and regulation of different subtypes of neutrophils can be achieved through interventions. Understanding the mechanisms of N1 neutrophil activation, recruitment, and regulation is crucial for harnessing their anti-tumor potential.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Shi Yong Neo, Xu Jing, Le Tong, Dongmei Tong, Juan Gao, Ziqing Chen, Mireia Cruz De Los Santos, Nutsa Burduli, Sabrina De Souza Ferreira, Arnika Kathleen Wagner, Evren Alici, Charlotte Rolny, Yihai Cao, Andreas Lundqvist
Summary: Downregulation of MHCI molecules on tumor cells is recognized as a resistance mechanism of cancer immunotherapy. This study found that the expression of MHCI by tumor cells influences systemic immune responses and NK cells play an important role in regulating tumor progression. Mice bearing MHCI-deficient tumor cells showed reduced tumor-associated extramedullary myelopoiesis in the spleen, which was reversed by NK cell depletion. Furthermore, an upregulation of TNF-alpha by NK cells was observed in mice with MHCI-expressing tumors, and inhibition of TNF-alpha enhanced host myelopoiesis in mice receiving adoptive transfer of tumor-experienced NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Qifeng Sun, Yan Gao, Yehui Zhang, Hongmei Cao, Jiajia Liu, Shi-Yong Neo, Keguang Chen, Yanping Bi, Jing Wu
Summary: Lung squamous cell carcinoma (Lung SCC) is a type of cancer with low survival rate due to metastasis and invasiveness. This study identified EMT-associated lncRNAs that can serve as biomarkers for predicting the prognosis of Lung SCC patients.
Article
Multidisciplinary Sciences
Xinsong Chen, Emmanouil G. Sifakis, Stephanie Robertson, Shi Yong Neo, Seong-Hwan Jun, Le Tong, Apple Tay Hui Min, John Lovrot, Roxanna Hellgren, Sara Margolin, Jonas Bergh, Theodoros Foukakis, Jens Lagergren, Andreas Lundqvist, Ran Ma, Johan Hartman
Summary: Breast cancer is a complex disease with multiple subtypes, and personalized therapy is needed due to patient-to-patient variability in drug response. This study establishes a whole-tumor cell culture (WTC) ex vivo model from breast tumors, which can accurately predict drug response and has potential for individualized therapy. The WTC model can also help stratify patients for clinical trials and validate biomarkers during drug development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Junzhe Zhao, Keene Lee, Han Chong Toh, Kong Peng Lam, Shi Yong Neo
Summary: This review focuses on the impact of obesity and altered lipid metabolism on liver cancer progression, discussing how these factors affect tumor, immune, and stroma cells in the tumor microenvironment, and how alterations in these cells contribute to tumor growth and dissemination. The review also touches upon the influence of obesity and altered lipid metabolism on tumor immune escape.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Ziqing Chen, Le Tong, Shi Yong Neo, Shuijie Li, Jiwei Gao, Susanne Schlisio, Andreas Lundqvist
Summary: Infusion of natural killer (NK) cells is a potential therapy for cancer patients. However, the activity of NK cells is suppressed by regulatory T (Treg) cells within solid tumors. This study investigates the expression of CD25 on NK cells and its association with persistence in Treg cell-containing solid tumor models. The results suggest that CD25(bright) NK cells isolated from IL-15 primed NK cells have increased proliferative and metabolic activity as well as enhanced ability to persist in Treg cell-containing tumor spheroids, supporting strategies to enhance CD25(bright) NK cells for adoptive NK cell therapy.
Review
Oncology
Shi Yong Neo, Shengli Xu, Joni Chong, Kong-Peng Lam, Jing Wu
Summary: Cell therapy is a growing field that involves the use of various types of immune cells, including T cells, for the treatment of human ailments such as cancer. This review focuses on cell therapy in the immuno-oncology space, discussing recent advances in different cell therapies and strategies to enhance therapeutic responses. Additionally, potential alternative immune cell types are explored to overcome the limitations of conventional adoptive cell therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Shalini Mani, Stephen J. Ralph, Geeta Swargiary, Madhu Rani, Samiksha Wasnik, Shashi Prakash Singh, Annu Devi
Summary: Mitochondria play crucial roles in cellular bioenergetics, cell growth, and death regulation. They are essential for tumor growth and can influence cancer treatment outcomes. Mitochondrial plasticity is related to the chemoresistance of cancer cells. Future research should focus on utilizing the changes in mitochondrial dynamics to improve cancer treatment and enhance survival outcomes.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Frank J. Echtenkamp, Ryo Ishida, Genesis M. Rivera-Marquez, Marisa Maisiak, Oleta T. Johnson, Jonathan H. Shrimp, Arnav Sinha, Stephen John Ralph, Ian Nisbet, Murali Krishna Cherukuri, Jason E. Gestwicki, Leonard M. Neckers
Summary: Studies have shown that the allosteric inhibitor of HSP70, JG-98, re-sensitizes castration-resistant prostate cancer to androgen deprivation drugs by targeting mitochondrial HSP70. The primary effect of JG-98 is inhibition of mitochondrial translation, disrupting electron transport chain activity. This highlights a potential new therapeutic approach for castration-resistant prostate cancer.
