Review
Biochemistry & Molecular Biology
Wa Du, Lu Ren, Milton H. Hamblin, Yanbo Fan
Summary: The process of angiogenesis, involving the formation of new blood vessels from existing ones, is critical in various physiological and pathological conditions. Endothelial cell metabolism, particularly glycolysis, has been shown to play a significant role in angiogenesis, with various regulators identified to modulate this process. Understanding the metabolic regulation in endothelial cells could lead to potential therapeutic strategies for angiogenesis-related diseases.
Article
Biochemistry & Molecular Biology
Gianni Colotti, Cristina Maria Failla, Pedro Miguel Lacal, Mariangela Ungarelli, Federica Ruffini, Patrizio Di Micco, Angela Orecchia, Veronica Morea
Summary: NRP-1 is a semaphorin receptor involved in neuron guidance and a co-receptor for certain VEGF isoforms, playing a critical role in angiogenesis and endothelial cell adhesion. Additionally, the interaction between NRP-1 and sVEGFR-1 has been investigated, with potential implications for developing novel anti-angiogenic compounds.
Article
Oncology
Eun-A. Kwak, Tasmia Ahmed, Paola Cruz Flores, Hannah R. Ortiz, Paul R. Langlais, Karthikeyan Mythreye, Nam Y. Lee
Summary: The study discovered that beta(IV)-spectrin is a powerful regulator of tumor angiogenesis, and loss of endothelial cell-specific beta(IV)-spectrin can significantly promote tumor growth and metastasis.
Article
Biochemistry & Molecular Biology
Elba Andrea Falcon-Ruiz, Joel Edmundo Lopez-Meza, Alejandra Ochoa-Zarzosa
Summary: This study evaluated the effects of plant antimicrobial peptides PaDef and gamma-thionin on angiogenesis. The results showed that these peptides can inhibit the proliferation and migration of endothelial cells, and regulate the activity of VEGF through interaction with its receptor.
Review
Cell Biology
Sophia Daum, Hannes Hagen, Erin Naismith, Dominik Wolf, Andreas Pircher
Summary: Tumor progression relies heavily on vascular supply, with inhibition of angiogenesis being a promising therapeutic strategy. Recent advancements in single cell RNA sequencing and preclinical observations allow for detailed characterization of the tumor microenvironment in NSCLC, leading to the identification of new aspects for personalized inhibition of angiogenesis. The tumor vasculature consists of various cellular subtypes that interact closely with other components of the tumor microenvironment, providing insight for the development of more targeted combinational therapies in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Nuria Mazo, Claudio D. Navo, Francesca Peccati, Jacopo Andreo, Cristina Airoldi, Gildas Goldsztejn, Pierre Carcabal, Imanol Usabiaga, Mariona Sodupe, Stefan Wuttke, Jesus H. Busto, Jesus M. Peregrina, Emilio J. Cocinero, Gonzalo Jimenez-Oses
Summary: This study presents the synthesis and characterization of peptides containing variations of the beta-amyloid hydrophobic core, as well as the use of experimental and computational techniques to investigate their properties in the gas phase, solid state, and aqueous solution. The introduction of a cyclic sulfamidate group effectively restricts and stabilizes the secondary structure of these hybrid peptides, maintaining this conformational bias in different environments. These peptides also exhibit moderate activity as beta-sheet breaker peptides, inhibiting the aggregation of beta-amyloid in vitro.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Ophthalmology
Wanju Yang, Yanning Yang, Shanshan Wan, Ya Xu, Jing Li, Lu Zhang, Wanruo Guo, Yijun Zheng, Yi Xiang, Yiqiao Xing
Summary: The study revealed that silencing PXN inhibited VEGF-A-induced invasion and angiogenesis of HUVECs through regulation of cell metabolism and mitochondrial damage, suggesting that PXN may be a potential target for antiangiogenic therapies.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Yunsong Li, Wei Bi, Bing Han, Tao Yuan, Long Shi, Yang Liu, Huanhuan Sun, Xueyan Li, Xiang Gao
Summary: MiR-203 is downregulated in cerebral infarction patients and MCAO mice, inhibiting HUVEC growth and migration. SLUG, a direct target of miR-203, reverses the inhibitory effect and plays a role in endothelial behaviors associated with cerebral infarction.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Review
Immunology
Mireia Medrano-Bosch, Blanca Simon-Codina, Wladimiro Jimenez, Elazer R. Edelman, Pedro Melgar-Lesmes
Summary: Monocytes are circulating leukocytes that interact with endothelial cells to regulate inflammation, angiogenesis, and tissue remodeling under physiological and pathophysiological conditions. They transdifferentiate into macrophages and release various substances that induce vascular and tissue remodeling or propagate inflammatory responses. The interactions between infiltrating monocytes and endothelial cells contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sophia Bou-Ghannam, Kyungsook Kim, David W. Grainger, Teruo Okano
Summary: This study demonstrated that mesenchymal stem cells (MSCs) can enhance their therapeutic potency through cultivation in a scaffold-free cell sheet technology to form 3D tissue-like structures. The transition from 2D to 3D culture promoted changes in cell morphology, cytoskeleton organization, and gene expression of pro-tissue regenerative cytokines, ultimately increasing MSC secretion of key growth factors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ha -Ram Park, Anahita Shiva, Portia Cummings, Seoyeon Kim, Sungsoo Kim, Eunhyeong Lee, Alessandra Leong, Subrata Chowdhury, Carrie Shawber, Richard Carvajal, Gavin Thurston, Joon-Yong An, Amanda W. Lund, Hee Won Yang, Minah Kim
Summary: The position of T-cells in the tumor microenvironment affects their ability to encounter the tumor and kill it. The vascular destabilizing factor ANGPT2 causes vascular integrity issues in the tumor periphery, leading to a lack of T-cell infiltration in the tumor core, which is associated with a poor response to immunotherapy.
Article
Multidisciplinary Sciences
Qingyun Li, Chuyue Zeng, Haizhen Liu, Kristen Wing Yu Yung, Chun Chen, Qiuling Xie, Yu Zhang, Stephanie Winn Chee Wan, Bertha Sze Wing Mak, Jiang Xia, Sheng Xiong, Jacky Chi Ki Ngo
Summary: A protein-protein interaction inhibitor named DBS1 was discovered to specifically block a conserved substrate docking groove unique to SRPKs, effectively inhibiting the activity of SRPKs and altering the splicing of VEGF. This provides a new direction for the development of SRPK inhibitors targeting a unique PPI site to combat angiogenic diseases.
Article
Oncology
Lawrence Kasherman, Shiru (Lucy) Liu, Katherine Karakasis, Stephanie Lheureux
Summary: This review discusses the mechanisms, current practices, and areas for development of angiogenesis in gynecologic cancers. It highlights the limited clinical activity of anti-angiogenic monotherapies and the ongoing focus on combination therapies. Future directions in clinical trials are also explored.
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.