Article
Biochemistry & Molecular Biology
Chun-Ming Chang, Chun-Chun Chang, Ho Yin Pekkle Lam, Shih-Yi Peng, Yi-Hsuan Lai, Bi-Da Hsiang, Yu-Yi Liao, Hao-Jen Hsu, Shinn-Jong Jiang
Summary: This study demonstrates that the RF16 peptide can effectively inhibit cell proliferation, migration, and invasion in breast cancer cells by blocking IL-8-induced activation of CXCR1/2. It also regulates the expression of epithelial-mesenchymal transition markers and inhibits downstream IL-8 signaling and inflammatory response through the MAPK and PI3K pathways. In a mouse model, RF16 synergistically enhances the antitumor efficacy of docetaxel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Kaitlyn E. Simpson, Katrina L. Watson, Roger A. Moorehead
Summary: This study aims to examine the functional impact of restoring miR-200 expression in claudin-low breast cancer cells. The results reveal that miR-200c/141 cluster expression can slow down tumor development and reduce lung metastasis in claudin-low breast cancer cells, which is achieved by downregulating the expression of MXRA8 gene.
Article
Nanoscience & Nanotechnology
Yu -Han Su, Han-Chen Lin, Hsing-Yen Li, Chih-Hsuan Lien, Yao-Hsiang Shih, Chian -Hui Lai
Summary: The aim of this study was to develop a carbohydrate silica nanocomposite, M-mDOX@SiO2, which can specifically target cancer cells and release the drug doxorubicin (DOX) specifically in an acidic tumor microenvironment (TME). The synthesized M-mDOX@SiO2 demonstrated high antitumor efficacy, making it a promising drug delivery carrier.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ana-Isabel Naranjo, Maria-Julia Gonzalez-Gomez, Victoriano Baladron, Jorge Laborda, Maria-Luisa Nueda
Summary: DLK2 expression levels can affect the tumor properties and growth dynamics of MDA-MB-231 breast cancer cells by regulating NOTCH signaling and other cell signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Meng-Die Yang, Yang Sun, Wen-Jun Zhou, Xiao-Zheng Xie, Qian-Mei Zhou, Yi-Yu Lu, Shi-Bing Su
Summary: This study demonstrated that the combination of resveratrol and cisplatin synergistically inhibits the viability of TNBC MDA-MB-231 cells and reduces their migration and invasion through regulating E-cadherin and vimentin expressions. In vivo, resveratrol enhanced the anti-tumor effect while reducing the side effects of cisplatin, possibly through regulating the expressions of PI3K/AKT, JNK, ERK, and NF-kappa B.
Article
Biochemistry & Molecular Biology
Qinhang Wu, Xuejiao Leng, Xuelin Ma, Qixuan Xu, Ruijun Ni, Yang Pan, Zhuolin Jin, Muhammad Kalim
Summary: Triptolide has a metastatic inhibitory effect on MDA-MB-231 cells by targeting ROCK1 and inhibiting the epithelial-mesenchymal transition. It suppresses cell proliferation, induces cell apoptosis, and reduces migration and invasion capabilities of the cells. Triptolide also affects the expressions of various proteins associated with metastasis.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Oncology
Xiaofeng Shen, Xiaochen Sun, Hua Chen, Binjie Lu, Yuanyuan Qin, Chenxi Zhang, Guoqiang Liang, Jiangping Wang, Pengfei Yu, Li Su, Qihan Ma, Yuwei Li
Summary: Bone metastasis is a common late complication of breast cancer, causing severe bone pain and pathologies such as fractures, closely related to osteoclasts. This study found that demethoxycurcumin (DMC) inhibits breast cancer cells and osteoclasts, and protects against bone destruction in vivo, suggesting its potential as a treatment for tumor-induced bone destruction.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Oncology
Xin Huang, Cunchuan Wang, Ningxia Wang
Summary: The study found that introducing V gamma 9V delta 2 T cells can synergistically enhance the inhibitory activity of CDDP against breast cancer cells, producing more pronounced effects at the cellular level.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Xiwei Ji, Xiangrui Meng, Qingfeng He, Xiaoqiang Xiang, Yufei Shi, Xiao Zhu
Summary: This study investigated the antitumor effects of foretinib on triple-negative breast cancer cells and its pharmacokinetic characteristics. The results showed that foretinib inhibited tumor growth in a dose-dependent manner and suppressed the expression of p-MET and HGF in both cells and tumors, suggesting that the decrease of p-MET and HGF may play a crucial role in the anti-breast cancer properties of foretinib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Summary: Pseudomonas aeruginosa DNM50 was identified as a biosurfactant-producing bacterium with 12 different congeners of rhamnolipid identified through structural characterization. The rhamnolipid showed radical scavenging activity with an IC50 value of 101.8 μg/ml and exhibited cytotoxic activity against MDA-MB-231 breast cancer cell line with a low IC50 of 0.05 μg/ml at 72 h of treatment. This suggests that DNM50RL may have potential in breast cancer treatment by targeting inhibition of p38MAPK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Marco Antonio Lacerda-Abreu, Thais Russo-Abrahao, Jose Roberto Meyer-Fernandes
Summary: Resveratrol inhibits the Na+-dependent Pi transporter, leading to reduced metastasis in breast cancer and potentially affecting the migration and invasion of cancer cells.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Environmental Sciences
Chun-Wen Cheng, Gwo-Tarng Sheu, Jing-Shiuan Chou, Pei-Han Wang, Yu-Chun Cheng, Chane-Yu Lai
Summary: The study demonstrated that soluble PM2.5 from building demolition sites can promote the survival and metastasis of triple-negative breast cancer cells, with increased cell viability, migration capacity, and activation of malignant signaling pathways in cancer cells exposed to the particulates.
Article
Biophysics
Rahman Hallaj, Zhaleh Ghafary, Osama kamal Mohammed, Raheleh Shakeri
Summary: The study developed an electrochemical biosensor for detecting the endogenous protein of breast cancer cells using RNA-cleaving DNAzymes. Thionine-modified gold nanoparticles and modified magnetic nanoparticles were used to prepare a probe, which was then pulled to the electrode surface with the help of a magnetic field. The presence of gold nanoparticle-thionine hybrid as an electroactive label ensured strong detection signals. The biosensor showed a linear range of (1.0E-06 to 1.0E+01) pg/ml for the protein marker and a detection limit of (1.0129E-07 pg/ml) using differential pulse voltammetry and electrochemical impedance spectroscopy (EIS).
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Xingjian Zhang, Trevor Chan, Michael Mak
Summary: This study investigated the phenotypes of highly aggressive cancer cells in confined microenvironments, revealing two distinct migratory phenotypes in fast migrating single cells and an increase in protrusions at the leading edge of cells under geometric confinement. The findings elucidate the impact of geometric constraints on cell behavior and morphodynamics associated with different cell phenotypes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kamylla Fernanda Souza de Souza, Danilo Tofoli, Indiara Correia Pereira, Kelly Juliana Filippin, Ana Tereza Gomes Guerrero, Edgar Julian Paredes-Gamero, Maria de Fatima Cepa Matos, Walmir Silva Garcez, Fernanda Rodrigues Garcez, Renata Trentin Perdomo
Summary: The study isolated three compounds from the leaves of Aniba heringeri, with compound 3 showing strong cytotoxicity against breast cancer cells and a high selective index. This compound exhibited promising apoptosis induction effects on triple-negative breast cancer cells, demonstrating potential as a prototype for targeting TNBC cells that are usually resistant to conventional therapies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Omonseigho O. Talton, Kathleen A. Pennington, Kelly E. Pollock, Keenan Bates, Lixin Ma, Mark R. Ellersieck, Laura C. Schulz
Article
Chemistry, Inorganic & Nuclear
Yawen Li, Lixin Ma, Vikram Gaddam, Fabio Gallazzi, Heather M. Hennkens, Michael Harmata, Michael R. Lewis, Carol A. Deakyne, Silvia S. Jurisson
INORGANIC CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Manjunath Yariswamy, Tadashi Yoshida, Anthony J. Valente, Hemanth Kumar Kandikattu, Siva S. V. P. Sakamuri, Jalahalli M. Siddesha, Sergiy Sukhanov, Zubaida Saifudeen, Lixin Ma, Ulrich Siebenlist, Jason D. Gardner, Bysani Chandrasekar
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Endocrinology & Metabolism
Shanyan Chen, Jiankun Cui, Tao Jiang, Emilia S. Olson, Quan-Yu Cai, Ming Yang, Wei Wu, James M. Guthrie, J. D. Robertson, Stuart A. Lipton, Lixin Ma, Roger Y. Tsien, Zezong Gu
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Endocrinology & Metabolism
Brian Bostick, Annayya R. Aroor, Javad Habibi, William Durante, Lixin Ma, Vincent G. DeMarco, Mona Garro, Melvin R. Hayden, Frank W. Booth, James R. Sowers
METABOLISM-CLINICAL AND EXPERIMENTAL
(2017)
Article
Endocrinology & Metabolism
Guanghong Jia, Javad Habibi, Annayya R. Aroor, Michael A. Hill, Vincent G. DeMarco, Li E. Lee, Lixin Ma, Brady J. Barron, Adam Whaley-Connell, James R. Sowers
METABOLISM-CLINICAL AND EXPERIMENTAL
(2018)
Article
Engineering, Electrical & Electronic
Miao Zhang, Lixin Ma, Ping Yu
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2019)
Article
Chemistry, Medicinal
Hang Xu, Rajendra P. Bandari, Li Lee, Ran Li, Ping Yu, Charles J. Smith, Lixin Ma
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Ran Li, Ruifang Gao, Yimei Wang, Zhuanzhuan Liu, Hang Xu, Ailin Duan, Fang Zhang, Lixin Ma
SCIENTIFIC REPORTS
(2020)
Article
Biophysics
Li E. Lee, Bysani Chandrasekar, Ping Yu, Lixin Ma
Summary: Noninvasive MRI T-2 mapping was used to quantify myocardial fibrosis in aging and pressure overload preclinical models. The study found an inverse correlation between T-2 relaxation times and myocardial fibrosis percentage in both aged and pressure-overloaded hearts. The results suggest that T-2 mapping MRI is a promising technique for characterizing myocardial fibrosis without contrast agents.
NMR IN BIOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Zhiyong Zheng, Ping Yu, Huili Cao, Mengyu Cheng, Thomas Zhou, Li E. Lee, Jens Ulstrup, Jingdong Zhang, Christian Engelbrekt, Lixin Ma
Summary: This study introduces a highly efficient ultrathin CuS nanocrystal coated with starch for enhanced photothermal therapy, utilizing a localized surface plasmon resonance at 980 nm wavelength. This novel nanomaterial demonstrates significant cancer cell killing capabilities.
Article
Nanoscience & Nanotechnology
Lalit N. Goswami, Shatadru Chakravarty, Quan-Yu Cai, Erik M. Shapiro, M. Frederick Hawthorne, Lixin Ma
Summary: A multimeric MRI blood pool contrast agent based on the closo-borane motif has been reported, showing high relaxivity and excellent contrast enhancement due to the presence of peripheral phenyl groups on the modified DTPA chelates that bind to human serum albumin.
ACS APPLIED BIO MATERIALS
(2021)
Article
Oncology
Xiaoqiang Qi, Ming Yang, Lixin Ma, Madeline Sauer, Diego Avella, Jussuf T. Kaifi, Jeffrey Bryan, Kun Cheng, Kevin F. Staveley-O'Carroll, Eric T. Kimchi, Guangfu Li
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Materials Science, Biomaterials
Anqi Chen, Jinghua Sun, Shijie Liu, Liping Li, Xiaoyang Peng, Lixin Ma, Ruiping Zhang
BIOMATERIALS SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Shatadru Chakravarty, Saurav J. Sarma, Lalit N. Goswami, Quan-Yu Cai, Erik M. Shapiro, M. Frederick Hawthorne, Lixin Ma
CHEMICAL COMMUNICATIONS
(2019)