Review
Immunology
Yuanyuan Li, Chenxi Tao, Na An, Haoqi Liu, Zhenhong Liu, Hongrui Zhang, Yikun Sun, Yanwei Xing, Yonghong Gao
Summary: Intracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. ICH remains a significant contributor to stroke-related mortality and has various complex pathological damage including mechanical damage, inflammatory response, and complement activation. This review summarizes the pathological mechanisms of brain injury after ICH, particularly focusing on the role of complement and its related mechanisms, as well as provides an overview of complement-targeted therapies for ICH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Lovisa Tobieson, Anna Gard, Karsten Ruscher, Niklas Marklund
Summary: This study found that there was a metabolic crisis in the perihemorrhagic zone (PHZ) after surgical evacuation of intracerebral hemorrhage (ICH), with significantly higher levels of both proinflammatory and anti-inflammatory cytokines compared to the seemingly normal cortex (SNX). This suggests a complex role for inflammatory mediators in the secondary injury cascades following ICH surgery, highlighting the need for targeted pharmacological interventions.
NEUROCRITICAL CARE
(2022)
Review
Immunology
Ruiyi Zhang, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with a poor prognosis. Despite numerous pre-clinical studies and clinical trials, effective treatment for ICH patients is still lacking. Minocycline, a neuroprotective pharmaceutical, shows promise in alleviating secondary brain injury after ICH. This review discusses the protective mechanisms, limitations, and clinical trial perspectives of minocycline in ICH, aiming to facilitate further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Katherine Holste, Fan Xia, Hugh J. L. Garton, Shu Wan, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage (ICH) leads to activation of the complement cascade, resulting in brain edema/injury, but inhibition of specific components of the complement cascade can reduce edema and improve functional outcomes. Additionally, complement plays a significant role in neurologic recovery after ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biology
Yan Zhang, Suliman Khan, Yang Liu, Rabeea Siddique, Ruiyi Zhang, Voon Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a devastating disease that affects approximately 2 million patients worldwide annually. This review focuses on understanding the pathological roles of gap junctions and hemichannels in secondary brain injury following ICH, with the aim of identifying effective therapeutic strategies for ICH.
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Article
Neurosciences
Huiyuan Yang, Qingrui Hu, Peng Yang, Xiaofeng Gao, Lijun Luo, Di Zhang, Qi Liu, Shengjun Mao
Summary: This study aimed to investigate the neuroprotective effects of BTY on intracerebral hemorrhage (ICH) and its underlying mechanisms. In vivo studies and cell experiments showed that BTY reduced brain edema and hematoma volume, improved neurological function and blood-brain barrier (BBB) permeability, and inhibited inflammatory factors and neuron apoptosis. Additionally, BTY suppressed oxidative stress, cell apoptosis, intracellular calcium influx, and stabilized mitochondrial membrane potential by reducing glutamate's excitotoxicity.
Review
Nutrition & Dietetics
Yuan Zhang, Wanpeng Yu, Christopher Flynn, Wenguang Chang, Lei Zhang, Man Wang, Wanhong Zheng, Peifeng Li
Summary: The pathophysiological process of intracerebral hemorrhage (ICH) involves complex mechanisms such as apoptosis, oxidative stress, and inflammation. Inflammatory response, as a key factor, plays a crucial role in the pathological process of acute brain injury and is associated with patient prognosis. Abnormal or dysregulated inflammatory responses can worsen cellular damage in the injured brain tissue. The NLRP3 inflammasome, a multiprotein complex in the cytosol, is activated after ICH, leading to neuroinflammation and aggravated brain edema. Additionally, the gut microbiota has been found to be essential in NLRP3 inflammasome activation. Changes in gut microbiota diversity and species influence neuroinflammation through NLRP3 inflammasome activation and the release of inflammatory cytokines. Conversely, the composition of the gut microbiota can be influenced by NLRP3 inflammasome activation. Therefore, targeting the microbe-gut-brain axis via NLRP3 inflammasome regulation could be a novel approach to protect against secondary brain injury in ICH patients.
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Review
Clinical Neurology
Zhe Li, Suliman Khan, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Stroke is the second leading cause of death worldwide, and intracerebral hemorrhage (ICH) is a type of stroke associated with poor neurological outcomes and high mortality. Experimental therapies have shown potential in improving functional outcomes for ICH patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Xingyu Zhang, Ye Yuan, Zongyi Xie
Summary: This review outlines the role of microglial pyroptosis in the pathological process of intracerebral hemorrhage (ICH) and highlights the potential of targeted strategies to inhibit microglial pyroptosis as a therapeutic approach.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Lingui Gu, Mingjiang Sun, Ruihao Li, Xingyu Zhang, Yihao Tao, Ye Yuan, Xu Luo, Zongyi Xie
Summary: Didymin treatment significantly improved neurobehavioral performance, reduced BBB disruption and brain water content, and mitigated microglial activation and neutrophil infiltration in the peri-hematoma tissue after ICH. The upregulation of Rkip expression by Didymin may play a key role in alleviating microglial pyroptosis and neuroinflammation through the Asc/Caspase-1/GSDMD pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Josephine M. Thomas, Irene Louca, Faye Bolan, Oana-Roxana Sava, Stuart M. Allan, Catherine B. Lawrence, Emmanuel Pinteaux
Summary: Intracerebral hemorrhage (ICH) is a deadly type of stroke with no approved restorative interventions, highlighting an unmet need. Similar to ischemic stroke (IS) and traumatic brain injury (TBI), ICH shares pathological features such as brain tissue loss, disruption of the blood-brain barrier, and inflammatory response. New biomaterials like hydrogels have shown therapeutic potential in IS and TBI, but research on their use in ICH therapy is still in its early stages.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Neurosciences
Guoqiang Yang, Xuehui Fan, Maryam Mazhar, Sijin Yang, Houping Xu, Nathupakorn Dechsupa, Li Wang
Summary: Intracerebral hemorrhage (ICH), a subtype of stroke with high mortality and disability rates, has a major socioeconomic burden, affecting two million people worldwide. Mesenchymal stem cells (MSCs) have shown potential in ICH treatment due to their neuroprotective, anti-inflammatory, and angiogenesis properties. This research field is important for developing new therapeutic strategies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jingchen Li, Xiaoyun Wu, Yanbo He, Song Wu, Erkun Guo, Yan Feng, Jipeng Yang, Jianliang Li
Summary: The study found that in patients with intracerebral hemorrhage, PINK1 mRNA was upregulated while its protein expression was downregulated. PINK1 protects against intracerebral hemorrhage-induced brain injury by promoting mitochondrial autophagy in microglial cells. Overexpression of PINK1 can rescue behavioral disorders induced by intracerebral hemorrhage.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Neuroimaging
Johannes Kaesmacher, Adnan Mujanovic, Kilian Treurniet, Manon Kappelhof, Thomas R. Meinel, Pengfei Yang, Jianmin Liu, Yongwei Zhang, Wenjie Zi, Qingwu Yang, Raul G. Nogueira, Kazumi Kimura, Yuji Matsumaru, Kentaro Suzuki, Bernard Yan, Peter J. Mitchell, Zhongrong Miao, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Jan Gralla, Jeffrey L. Saver, Urs Fischer
Summary: This study investigated the acceptable level of uncertainty for experienced stroke clinicians in deciding whether to administer intravenous thrombolysis (IVT) before endovascular treatment (EVT). The results showed that clinicians would generally feel comfortable skipping IVT if there was reasonable comparability between IVT+EVT and EVT alone, with no more than 3% of patients being unable to achieve functional independence at 90 days due to skipping IVT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Geriatrics & Gerontology
Zhouzhou Peng, Hui Lu, Qingwu Yang, Qi Xie
Summary: This review introduces the method of astrocyte reprogramming and its application in stroke. By targeting key transcription factors or microRNAs, astrocytes in the mouse brain could be reprogrammed into functional neurons. Current controversies over the lack of cell lineage tracing and single-cell sequencing experiments are also summarized.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Qin Zhang, Wei-lin Kong, Jun-Jie Yuan, Qiong Chen, Chang-Xiong Gong, Liang Liu, Fa-Xiang Wang, Jia-Cheng Huang, Guo-Qiang Yang, Kai Zhou, Rui Xu, Xiao-Yi Xiong, Qing-Wu Yang
Summary: This study investigates the contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection in an intracerebral hemorrhage-induced acute brain injury rat model. The findings reveal that neuroinflammation-associated genes are upregulated in ICH rat brains regardless of age, with interferon-gamma response genes activated in both age groups. Anti-IFN-gamma treatment effectively reduces acute brain injury in older rats. Additionally, histone modifications, particularly H3K4me3 and H3K27me3, are redistributed in neuroinflammation-associated genes in both age groups and are correlated with gene expression. These findings highlight the potential of targeting histone modifications as a therapeutic approach for age-related diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Fan Qinlin, Wang Bingqiao, Hu Linlin, Shi Peixia, Xie Lexing, Yang Lijun, Yang Qingwu
Summary: The study identified that overexpression of miR-129-5p significantly reduced neuronal cell autophagy levels and expressions of related proteins. It also revealed that FEZ1, SCOC, ULK1, and NBR1 are target genes of miR-129-5p and can form a protein complex. These findings suggest a potential regulatory role of miR-129-5p in autophagy processes and neuronal function.
Article
Immunology
Chang Liu, Fengli Li, Shuai Liu, Qiong Chen, Hongfei Sang, Qingwu Yang, Kai Zhou, Wenji Zi
Summary: MCE plays a crucial role in worsening prognosis for ABAO after EVT. A high neutrophil count at admission is associated with MCE and a poor outcome among ABAO patients, and incorporating this factor into clinical decision-making could guide immunomodulation therapy effectively.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Likun Wang, Sheng Luo, Siying Ren, Hui Yu, Guiquan Shen, Guofeng Wu, Qingwu Yang
Summary: This study found that irregular-shaped hematoma was an independent predictor of postoperative rehemorrhage after sMIS, which can be used to assess the risk of rehemorrhage in patients before surgery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jiacheng Huang, Maolin Wang, Fengli Li, Weilin Kong, Da Liu, Huagang Li, Peiyang Zhou, Zhizhong Yan, Yan Wang, Jiaxing Song, Weidong Luo, Shuai Liu, Linyu Li, Jinrong Hu, Yan Tian, Zhongming Qiu, Rui Xu, Wouter J. Schonewille, Wenjie Zi, Qingwu Yang
Summary: This study identified potential modifiable risk factors for early mortality in patients with basilar artery occlusion, including recanalization failure, herniation, gastrointestinal hemorrhage, and pneumonia.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Wenjie Zi, Jiaxing Song, Zhongming Qiu, Weilin Kong, Jiacheng Huang, Weidong Luo, Shuai Liu, Hongfei Sang, Jie Yang, Linyu Li, Yan Tian, Jinrong Hu, Jeffrey L. Saver, Raul G. Nogueira, Fengli Li, Qingwu Yang
Summary: This study aims to compare the efficacy and safety of tirofiban with aspirin in patients with acute ischemic stroke. The study will be conducted in multiple stroke centers in China and will evaluate the functional outcomes and potential safety issues in patients after 90 days of treatment.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Immunology
Lexing Xie, Shuang Zhang, Li Huang, Zhouzhou Peng, Hui Lu, Qian He, Ru Chen, Linlin Hu, Bingqiao Wang, Baoliang Sun, Qingwu Yang, Qi Xie
Summary: Stroke is a leading cause of death and disability worldwide. Researchers have found that peripheral immune cells infiltrate the brain and cause inflammation after cerebral ischemia. However, it is still unclear how and when these immune cells affect the central inflammatory response, and whether interventions targeting these processes can reduce ischemia-reperfusion injury.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Zhouzhou Peng, Jiaxing Song, Linyu Li, Changwei Guo, Jie Yang, Weilin Kong, Jiacheng Huang, Jinrong Hu, Shuai Liu, Yan Tian, Dahong Yang, Fengli Li, Wenjie Zi, Dongjing Xie, Qingwu Yang
Summary: This study aimed to evaluate the association between stress hyperglycemia ratio (SHR) and clinical outcomes at 90 days in acute ischemic stroke due to large vessel occlusion receiving endovascular treatment. The study found that SHR was negatively associated with the odds of achieving favorable functional outcomes at 90 days.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Zhiyi Chen, Xuerong Liu, Qingwu Yang, Yan-Jiang Wang, Kuan Miao, Zheng Gong, Yang Yu, Artemiy Leonov, Chunlei Liu, Zhengzhi Feng, Hu Chuan-Peng
Summary: This study systematically evaluated the clinical applicability and reporting quality of neuroimaging-based AI models for psychiatric diagnosis. The results showed high risk of bias and poor reporting quality. The application of these models in clinical practice still faces challenges and needs to address the risk of bias and improve reporting quality.
Review
Neurosciences
Jiahao Zhang, Zeyu Zhang, Xiaoyu Wang, Yibo Liu, Qian Yu, Kaikai Wang, Yuanjian Fang, Cameron Lenahan, Maohua Chen, Sheng Chen
Summary: Spontaneous subarachnoid hemorrhage (SAH) is a devastating form of stroke with limited treatment options and poor patient outcomes. Early brain injury (EBI) occurring within 72 hours after SAH has been suggested to contribute to its poor clinical outcomes. Oxidative stress, which damages subcellular organelles, such as mitochondria and endoplasmic reticulum (ER), is recognized as a main mechanism of EBI. This review discusses the connection between oxidative stress and subcellular organelles after SAH and summarizes promising therapeutic options based on these mechanisms.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Chenhao Zhao, Ting Hu, Weilin Kong, De Yang, Junfang Wan, Kefeng Lv, Jiasheng Liao, Zhao Chen, He Jiang, Deping Wu, Ping Yang, Wenjie Zi, Fengli Li, Qingwu Yang
Summary: This study aimed to evaluate the impact of FPE on efficacy and safety for patients with acute basilar artery occlusion (BAO). The results showed that achieving FPE was strongly associated with favorable clinical outcomes, lower mortality rate, and shorter time to recanalization. Compared with final successful reperfusion, FPE also independently contributed to favorable outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Jie Yang, Fengli Li, Zhongming Qiu, Yan Wang, Jun Luo, Youlin Wu, Guoyong Zeng, Yue Wan, Shuai Liu, Chengsong Yue, Jiaxing Song, Weidong Luo, Chang Liu, Linyu Li, Ruidi Sun, Jiacheng Huang, Hongfei Sang, Chenhao Zhao, Qingwu Yang, Wenjie Zi
Summary: The study aimed to investigate the efficacy and safety of combining endovascular treatment (EVT) with standard medical treatment (SMT) in Chinese patients with acute basilar artery occlusion (BAO) within 6 hours of occlusion. Patients were divided into SMT-alone group or EVT+SMT group. Results showed that EVT was associated with a higher rate of favorable functional outcome and a lower proportion of deaths. Predictors of favorable outcome in the EVT+SMT group included younger age, lower baseline National Institutes of Health Stroke Scale score, higher baseline posterior circulation Alberta Stroke Program Early CT Score, absence of diabetes mellitus, and modified Thrombolysis in Cerebral Infarction scores 2b-3.
JOURNAL OF NEUROSURGERY
(2023)