Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors

HDAC5 controls the functions of Foxp3+ T-regulatory and CD8+ T cells

(2016) Haiyan Xiao et al.   INTERNATIONAL JOURNAL OF CANCER

Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis

(2015) Eloisa Romano et al.   ANNALS OF THE RHEUMATIC DISEASES

A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis

(2015) Ryosuke Saigusa et al.   EXPERIMENTAL DERMATOLOGY

Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice

(2015) Yingying Dong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma

(2015) Pei-Suen Tsou et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines

(2015) Pei-Suen Tsou et al.   RHEUMATOLOGY

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis

(2015) Celestina Mazzotta et al.   ARTHRITIS RESEARCH & THERAPY

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression

(2014) Chiara Angiolilli et al.   ANNALS OF THE RHEUMATIC DISEASES

Altered MCM Protein Levels and Autophagic Flux in Aged and Systemic Sclerosis Dermal Fibroblasts

(2014) Verónica I. Dumit et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cardiac Myocyte-Derived Follistatin-Like 1 Prevents Renal Injury in a Subtotal Nephrectomy Model

(2014) S. Hayakawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative

(2013) Frank van den Hoogen et al.   ANNALS OF THE RHEUMATIC DISEASES

Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis

(2013) Yohei Ichimura et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Cysteine-rich Protein 61 (CCN1) Domain-specific Stimulation of Matrix Metalloproteinase-1 Expression through αVβ3 Integrin in Human Skin Fibroblasts

(2013) Zhaoping Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

diffReps: Detecting Differential Chromatin Modification Sites from ChIP-seq Data with Biological Replicates

(2013) Li Shen et al.   PLoS One

Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition

(2012) Simona Serratì et al.   ARTHRITIS AND RHEUMATISM

Fibroblast autophagy in fibrotic disorders

(2012) Domenico Del Principe et al.   JOURNAL OF PATHOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Follistatin-Like 3 Mediates Paracrine Fibroblast Activation by Cardiomyocytes

(2012) Kalyani D. Panse et al.   Journal of Cardiovascular Translational Research

Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells

(2011) Oren Ram et al.   CELL

Overexpression of VEGF 165 b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis

(2011) Mirko Manetti et al.   CIRCULATION RESEARCH

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation

(2011) Wei Zhao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis

(2011) Dawei Li et al.   ARTHRITIS RESEARCH & THERAPY

Angiogenesis and Vasculopathy in Systemic Sclerosis: Evolving Concepts

(2011) Bradley J. Rabquer et al.   Current Rheumatology Reports

Role of Afadin in Vascular Endothelial Growth Factor– and Sphingosine 1-Phosphate–Induced Angiogenesis

(2010) Hideto Tawa et al.   CIRCULATION RESEARCH

DIP2A Functions as a FSTL1 Receptor

(2010) Noriyuki Ouchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells

(2009) C. Urbich et al.   BLOOD

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY