标题
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 10, Issue 12, Pages 945-963
出版商
Springer Nature
发表日期
2011-12-01
DOI
10.1038/nrd3599
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cellular senescence controls fibrosis in wound healing
- (2016) Joon-Il Jun et al. Aging-US
- CCN3 Impairs Osteoblast and Stimulates Osteoclast Differentiation to Favor Breast Cancer Metastasis to Bone
- (2011) Véronique Ouellet et al. AMERICAN JOURNAL OF PATHOLOGY
- Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis
- (2011) Amélie Dendooven et al. BIOMARKERS
- Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF
- (2011) D. Lai et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- CCN1/CYR61: the very model of a modern matricellular protein
- (2011) Lester F. Lau CELLULAR AND MOLECULAR LIFE SCIENCES
- Connective Tissue Growth Factor Acts as a Therapeutic Agent and Predictor for Peritoneal Carcinomatosis of Colorectal Cancer
- (2011) B.-R. Lin et al. CLINICAL CANCER RESEARCH
- Effect of CCN2 on FGF2-Induced Proliferation and MMP9 and MMP13 Productions by Chondrocytes
- (2011) Takashi Nishida et al. ENDOCRINOLOGY
- Expression of tumor-promoting Cyr61 is regulated by hTRA2- 1 and acidosis
- (2011) M. Hirschfeld et al. HUMAN MOLECULAR GENETICS
- Impact of CCN3 (NOV) glycosylation on migration/invasion properties and cell growth of the choriocarcinoma cell line Jeg3
- (2011) W. Yang et al. HUMAN REPRODUCTION
- Kallikrein-related Peptidase 12 Hydrolyzes Matricellular Proteins of the CCN Family and Modifies Interactions of CCN1 and CCN5 with Growth Factors
- (2011) Audrey Guillon-Munos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity
- (2011) Cecilia Vial et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
- (2011) G. Lorenzatti et al. JOURNAL OF CELL SCIENCE
- Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion
- (2011) Lincoln A. Edwards et al. JNCI-Journal of the National Cancer Institute
- CCN5, a Novel Transcriptional Repressor of the Transforming Growth Factor Signaling Pathway
- (2011) M. Sabbah et al. MOLECULAR AND CELLULAR BIOLOGY
- Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
- (2011) Inamul Haque et al. Molecular Cancer
- Connective Tissue Growth Factor Is Required for Normal Follicle Development and Ovulation
- (2011) Takashi Nagashima et al. MOLECULAR ENDOCRINOLOGY
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy
- (2011) Juan F. Navarro-González et al. Nature Reviews Nephrology
- Inflammation in diabetic retinopathy
- (2011) Johnny Tang et al. PROGRESS IN RETINAL AND EYE RESEARCH
- The role of CCN2 in cartilage and bone development
- (2011) Satoshi Kubota et al. Journal of Cell Communication and Signaling
- Defining normal and abnormal fetal growth: promises and challenges
- (2010) Jun Zhang et al. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- CCN3 Inhibits Neointimal Hyperplasia Through Modulation of Smooth Muscle Cell Growth and Migration
- (2010) Tatsushi Shimoyama et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- CCN2 is required for bleomycin-induced skin fibrosis in mice
- (2010) Shangxi Liu et al. ARTHRITIS AND RHEUMATISM
- Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis
- (2010) Sonali Sonnylal et al. ARTHRITIS AND RHEUMATISM
- The CCN family: A new class of inflammation modulators?
- (2010) L. Kular et al. BIOCHIMIE
- CCN2 (CTGF) Gene Polymorphism Is a Novel Prognostic Risk Factor for Cardiovascular Outcomes in Hemodialysis Patients
- (2010) Mario Cozzolino et al. BLOOD PURIFICATION
- Colorectal Cancer Susceptibility Quantitative Trait Loci in Mice as a Novel Approach to Detect Low-Penetrance Variants in Humans: A Two-Stage Case-Control Study
- (2010) C. Fernandez-Rozadilla et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Cyr61 Mediates Hepatocyte Growth Factor–Dependent Tumor Cell Growth, Migration, and Akt Activation
- (2010) C. Rory Goodwin et al. CANCER RESEARCH
- Matricellular Signaling Molecule CCN1 Attenuates Experimental Autoimmune Myocarditis by Acting as a Novel Immune Cell Migration Modulator
- (2010) Madlen Rother et al. CIRCULATION
- Decreased Expression of Cyr61 Is Associated with Prostate Cancer Recurrence after Surgical Treatment
- (2010) K. B. D'Antonio et al. CLINICAL CANCER RESEARCH
- Phase 1 Study of Anti-CTGF Monoclonal Antibody in Patients with Diabetes and Microalbuminuria
- (2010) S. G. Adler et al. Clinical Journal of the American Society of Nephrology
- Role of CCN, a vertebrate specific gene family, in development
- (2010) Ken-ichi Katsube et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Connective Tissue Growth Factor Is Required for Skeletal Development and Postnatal Skeletal Homeostasis in Male Mice
- (2010) Ernesto Canalis et al. ENDOCRINOLOGY
- Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme
- (2010) Dong Yin et al. INTERNATIONAL JOURNAL OF CANCER
- CYR61 Regulates BMP-2-dependent Osteoblast Differentiation through the αvβ3Integrin/Integrin-linked Kinase/ERK Pathway
- (2010) Jen-Liang Su et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
- (2010) Mitsuaki Ono et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA
- (2010) Yoshiki Mukudai et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model
- (2010) Chang H. Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Expression of CTGF and Cyr61 in colorectal cancer
- (2010) R. Ladwa et al. JOURNAL OF CLINICAL PATHOLOGY
- Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages
- (2010) T. Bai et al. JOURNAL OF IMMUNOLOGY
- Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes
- (2010) B. Wang et al. JOURNAL OF MEDICAL GENETICS
- The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis
- (2010) Pyoung Oh Yoon et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
- (2010) Joon-Il Jun et al. NATURE CELL BIOLOGY
- Cyr61/CCN1 Displays High-Affinity Binding to the Somatomedin B 1–44 Domain of Vitronectin
- (2010) Ivo M. B. Francischetti et al. PLoS One
- A Mouse Strain Where Basal Connective Tissue Growth Factor Gene Expression Can Be Switched from Low to High
- (2010) Heather E. Doherty et al. PLoS One
- CCN5: biology and pathophysiology
- (2010) Joshua W. Russo et al. Journal of Cell Communication and Signaling
- A novel role of CCN3 in regulating endothelial inflammation
- (2010) Zhiyong Lin et al. Journal of Cell Communication and Signaling
- CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease
- (2009) Bruce L. Riser et al. AMERICAN JOURNAL OF PATHOLOGY
- Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1
- (2009) Arjen B. Blom et al. ARTHRITIS AND RHEUMATISM
- A critical role of Cyr61 in interleukin-17âdependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis
- (2009) Qiuyu Zhang et al. ARTHRITIS AND RHEUMATISM
- Connective Tissue Growth Factor Confers Drug Resistance in Breast Cancer through Concomitant Up-regulation of Bcl-xL and cIAP1
- (2009) M.-Y. Wang et al. CANCER RESEARCH
- The Role of Tumor Cell-Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth
- (2009) K. L. Bennewith et al. CANCER RESEARCH
- Arterial gene transfer of the TGF-β signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF
- (2009) Rishi Kundi et al. CARDIOVASCULAR RESEARCH
- Nephroblastoma Overexpressed (Nov) Inactivation Sensitizes Osteoblasts to Bone Morphogenetic Protein-2, But Nov Is Dispensable for Skeletal Homeostasis
- (2009) Ernesto Canalis et al. ENDOCRINOLOGY
- Regulation of chondrocytic phenotype by micro RNA 18a: Involvement ofCcn2/Ctgfas a major target gene
- (2009) Toshihiro Ohgawara et al. FEBS LETTERS
- Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes
- (2009) ZhenYue Tong et al. HEPATOLOGY
- Prognostic relevance of CCN3 in Ewing sarcoma
- (2009) Bernard Perbal et al. HUMAN PATHOLOGY
- Association of polymorphisms of SORBS1, GCK and WISP1 with hypertension in community-dwelling Japanese individuals
- (2009) Yoshiji Yamada et al. HYPERTENSION RESEARCH
- WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor-α (TNF-α)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF-α-induced Cardiomyocyte Death
- (2009) Kaliyamurthi Venkatachalam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Silencing cAMP-response Element-binding Protein (CREB) IdentifiesCYR61as a Tumor Suppressor Gene in Melanoma
- (2009) Andrey S. Dobroff et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes
- (2009) Alain Dessein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Association Between a CTGF Gene Polymorphism and Systemic Sclerosis in a French Population
- (2009) B. GRANEL et al. JOURNAL OF RHEUMATOLOGY
- CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF- B
- (2009) E. Sanchez-Lopez et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo
- (2009) V. Juric et al. MOLECULAR AND CELLULAR BIOLOGY
- Matrix Protein CCN1 Is Critical for Prostate Carcinoma Cell Proliferation and TRAIL-Induced Apoptosis
- (2009) C. A. Franzen et al. MOLECULAR CANCER RESEARCH
- Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and β-Cell Proliferation during Embryogenesis
- (2009) Laura A. Crawford et al. MOLECULAR ENDOCRINOLOGY
- Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
- (2009) Andrew R Reynolds et al. NATURE MEDICINE
- Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis
- (2009) Mysore K. Phanish et al. NEPHRON EXPERIMENTAL NEPHROLOGY
- Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload
- (2009) Anna N. Panek et al. PLoS One
- Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis
- (2009) Kazuhisa Nozawa et al. ARTHRITIS RESEARCH & THERAPY
- Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?
- (2009) Roger M. Mason Journal of Cell Communication and Signaling
- Alternative splicing of CCN mRNAs …. it has been upon us
- (2009) Bernard Perbal Journal of Cell Communication and Signaling
- Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals
- (2009) David R. Brigstock Journal of Cell Communication and Signaling
- Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo
- (2009) David R. Brigstock Journal of Cell Communication and Signaling
- Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines
- (2009) Chih-Chiun Chen et al. Journal of Cell Communication and Signaling
- Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
- (2009) Andrew Leask et al. Journal of Cell Communication and Signaling
- Substance P-Mediated Expression of the Pro-Angiogenic Factor CCN1 Modulates the Course of Colitis
- (2008) Hon-Wai Koon et al. AMERICAN JOURNAL OF PATHOLOGY
- A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype
- (2008) B Rueda et al. ANNALS OF THE RHEUMATIC DISEASES
- Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population
- (2008) Y Kawaguchi et al. ANNALS OF THE RHEUMATIC DISEASES
- CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model
- (2008) Hironobu Matsumae et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1
- (2008) Yuko Katsuki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Involvement of Cyr61 in growth, migration and metastasis of prostate cancer cells
- (2008) Z-J Sun et al. BRITISH JOURNAL OF CANCER
- CCN3/Nephroblastoma Overexpressed Matricellular Protein Regulates Integrin Expression, Adhesion, and Dissemination in Melanoma
- (2008) V. Vallacchi et al. CANCER RESEARCH
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- miR-133 and miR-30 Regulate Connective Tissue Growth Factor
- (2008) Rudy F. Duisters et al. CIRCULATION RESEARCH
- Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse
- (2008) Mark Baguma-Nibasheka et al. DEVELOPMENTAL DYNAMICS
- Plasma Connective Tissue Growth Factor Is an Independent Predictor of End-Stage Renal Disease and Mortality in Type 1 Diabetic Nephropathy
- (2008) T. Q. Nguyen et al. DIABETES CARE
- Skeletal Overexpression of Connective Tissue Growth Factor Impairs Bone Formation and Causes Osteopenia
- (2008) Anna Smerdel-Ramoya et al. ENDOCRINOLOGY
- Signal transduction involved in CTGF-induced production of chemokines in mesangial cells
- (2008) Sheng-Hua Wu et al. GROWTH FACTORS
- Cyr61, a member of ccn (connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed) family, predicts survival of patients with endometrial cancer of endometrioid subtype
- (2008) Hidemichi Watari et al. GYNECOLOGIC ONCOLOGY
- Functions and mechanisms of action of CCN matricellular proteins
- (2008) Chih-Chiun Chen et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- CCN Family 2/Connective Tissue Growth Factor Modulates BMP Signalling as a Signal Conductor, Which Action Regulates the Proliferation and Differentiation of Chondrocytes
- (2008) A. Maeda et al. JOURNAL OF BIOCHEMISTRY
- Connective Tissue Growth Factor and Susceptibility to Renal and Vascular Disease Risk in Type 1 Diabetes
- (2008) Ayad A. Jaffa et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Connective Tissue Growth Factor Is Necessary for Retinal Capillary Basal Lamina Thickening in Diabetic Mice
- (2008) Esther J. Kuiper et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer
- (2008) Sandra E Ghayad et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- G Protein-Coupled Receptors Go Extracellular: RhoA Integrates the Integrins
- (2008) C. T. Walsh et al. MOLECULAR INTERVENTIONS
- Wound repair and regeneration
- (2008) Geoffrey C. Gurtner et al. NATURE
- Cancer as an overhealing wound: an old hypothesis revisited
- (2008) Matthias Schäfer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies
- (2008) Anna P. Lillis et al. PHYSIOLOGICAL REVIEWS
- The CCN family of proteins: structure–function relationships
- (2008) Kenneth P. Holbourn et al. TRENDS IN BIOCHEMICAL SCIENCES
- Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo
- (2008) Mark Sisco et al. WOUND REPAIR AND REGENERATION
- Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications
- (2008) Shi Fang Yan et al. Nature clinical practice. Endocrinology & metabolism
- Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice
- (2007) H. Yokoi et al. KIDNEY INTERNATIONAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation