Fibroblast autophagy in fibrotic disorders

Hyperphagia by self- and xeno-cannibalism: Cell death by indigestion? A reminiscence of the Phedrus Fabula “Rana Rupta et Bos”?

(2014) Antonella Tinari et al.   Autophagy

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Reduced expression of microtubule-associated protein 1 light chain 3 in hypertrophic scars

(2012) Ji-Hong Shi et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Autophagy fuels tissue fibrogenesis

(2012) Virginia Hernández-Gea et al.   Autophagy

Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease

(2012) René L. Vidal et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

(2012) Hildegard I.D. Mack et al.   Autophagy

Fibroblast Activation Protein in Remodeling Tissues

(2012) M. Jacob et al.   CURRENT MOLECULAR MEDICINE

Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants

(2012) Colleen Olive   Expert Review of Vaccines

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1

(2012) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress

(2012) Huabo Su et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury

(2011) Hong-Zhen Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8

(2011) Serban P. Georgescu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

(2011) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Beclin 1-independent autophagy contributes to apoptosis in cortical neurons

(2011) Yulia Grishchuk et al.   Autophagy

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Matrix remodeling stimulates stromal autophagy, “fueling” cancer cell mitochondrial metabolism and metastasis

(2011) Remedios Castello-Cros et al.   CELL CYCLE

AMPK Activates Autophagy by Phosphorylating ULK1

(2011) Kai Mao et al.   CIRCULATION RESEARCH

Removing Protein Aggregates: The Role of Proteolysis in Neurodegeneration

(2011) D. A.T. Nijholt et al.   CURRENT MEDICINAL CHEMISTRY

Defective Autophagy in Fibroblasts May Contribute to Fibrogenesis in Autoimmune Processes

(2011) Domenico Del Principe et al.   CURRENT PHARMACEUTICAL DESIGN

Macrophages in skin injury and repair

(2011) Babak Mahdavian Delavary et al.   IMMUNOBIOLOGY

Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response

(2011) Anna Maria Giammarioli et al.   INTERNATIONAL JOURNAL OF CANCER

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

(2011) Caroline Bruns et al.   JOURNAL OF CELL BIOLOGY

TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR)

(2011) Anna Goc et al.   JOURNAL OF CELLULAR PHYSIOLOGY

AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300

(2011) Joong-Yeon Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

Loss of PTEN Expression by Dermal Fibroblasts Causes Skin Fibrosis

(2011) Sunil K. Parapuram et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Alternative origins of stroma in normal organs and disease

(2011) Mikhail G. Kolonin et al.   Stem Cell Research

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Macrophages in Synovial Inflammation

(2011) Aisling Kennedy et al.   Frontiers in Immunology

Effect of heat shock protein 47 on collagen synthesis of keloid in vivo

(2010) Jun-Jie Chen et al.   ANZ JOURNAL OF SURGERY

Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis

(2010) Ayumi Yoshizaki et al.   ARTHRITIS AND RHEUMATISM

Fibrosis and immune dysregulation in systemic sclerosis

(2010) Carlo Chizzolini et al.   AUTOIMMUNITY REVIEWS

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

(2010) Jun Wei et al.   AUTOIMMUNITY REVIEWS

Regulation of autophagy by transforming growth factor-β (TGF-β) signaling

(2010) Hiroshi I. Suzuki et al.   Autophagy

The engulfment receptor Draper is required for autophagy during cell death

(2010) Christina K. McPhee et al.   Autophagy

Plasma membrane helps autophagosomes grow

(2010) Brinda Ravikumar et al.   Autophagy

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation

(2010) Pablo Aránguiz-Urroz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis

(2010) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Defective autophagy control by the p53 rheostat in cancer

(2010) Lorenzo Galluzzi et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Regulation of autophagy in mammals and its interplay with apoptosis

(2010) Gian Maria Fimia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antigen processing via autophagy—not only for MHC class II presentation anymore?

(2010) Christian Münz   CURRENT OPINION IN IMMUNOLOGY

Where do they come from? Insights into autophagosome formation

(2010) Maho Hamasaki et al.   FEBS LETTERS

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-γ) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen

(2010) Darab Ghadimi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Reevaluation of Neurodegeneration in lurcher Mice: Constitutive Ion Fluxes Cause Cell Death with, Not by, Autophagy

(2010) J. Nishiyama et al.   JOURNAL OF NEUROSCIENCE

Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders

(2010) M. Pang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

The immunology of fibrosis: innate and adaptive responses

(2010) Georg Wick et al.   TRENDS IN IMMUNOLOGY

Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress

(2010) Yong-Joo Shin et al.   ARTHRITIS RESEARCH & THERAPY

Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single-blind pilot study

(2009) Tien-I Karleen Su et al.   ARTHRITIS AND RHEUMATISM

Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress

(2009) Yoshihito Ishida et al.   Autophagy

Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization

(2009) Elly van Riet et al.   BMC IMMUNOLOGY

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

Noncanonical transforming growth factor β signaling in scleroderma fibrosis

(2009) Maria Trojanowska   CURRENT OPINION IN RHEUMATOLOGY

Alternatively activated macrophages in infection and autoimmunity

(2009) DeLisa Fairweather et al.   JOURNAL OF AUTOIMMUNITY

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Dendritic Cells Stimulated via TLR7 and/or TLR8 Induce the Sequential Production of Il-10, IFN- , and IL-17A by Naive CD4+ T Cells

(2009) V. Lombardi et al.   JOURNAL OF IMMUNOLOGY

Interferon gamma for idiopathic pulmonary fibrosis

(2009) Demosthenes Bouros   LANCET

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Connective tissue growth factor is induced in bleomycin-induced skin scleroderma

(2009) Shangxi Liu et al.   Journal of Cell Communication and Signaling

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease

(2008) Francesco Boin et al.   ARTHRITIS AND RHEUMATISM

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Xeno-Cannibalism as an Exacerbation of Self-Cannibalism: A Possible Fruitful Survival Strategy for Cancer Cells

(2008) W. Malorni et al.   CURRENT PHARMACEUTICAL DESIGN

Mechanisms of Fibrogenesis

(2008) Tatiana Kisseleva et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy of Rapamycin in Scleroderma: A Case Study

(2008) Levi Fried et al.   Lymphatic Research and Biology

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is an adaptive response in desmin-related cardiomyopathy

(2008) P. Tannous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

The regulation of matrix metalloproteinases and their inhibitors

(2007) I CLARK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY