Review
Medicine, Research & Experimental
Bo Jiao, Shiyang Liu, Xi Tan, Pei Lu, Danning Wang, Hui Xu
Summary: Semaphorins, particularly Class-3 Semaphorins (SEMA3), have broad influences on pathophysiological processes such as bone remodeling, immune responses, and angiogenesis. While angiogenesis plays a crucial role in many diseases, targeting it for therapy has been challenging due to its complex mechanisms. Investigating the specific mechanisms of SEMA3 in angiogenesis may lead to novel therapeutic approaches for diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Yi-Fei Zhang, Yu Zhang, Dong-Dong Jia, Hong-Yu Yang, Meng-Die Cheng, Wen-Xiu Zhu, Hui Xin, Pei-Feng Li, Yin-Feng Zhang
Summary: PLXND1, a member of the Plexin family of transmembrane proteins, plays crucial roles in axonal guidance and can act as both a tumour promoter and suppressor. Mutations in PLXND1 or its ligand Semaphorin 3E have been linked to serious cardiovascular diseases. The role of PLXND1 in cardiovascular development and diseases is gaining research interest due to its potential as a biomarker and therapeutic target.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Rheumatology
Paola Cipriani, Piero Ruscitti, Ilenia Di Cola, Marta Vomero, Franca Abbruzzese, Elena Di Nino, Rebecca Ross, Francesco Del Galdo, Roberto Giacomelli
Summary: CD248 has anti-angiogenic effects in vitro by reducing tube formation and inducing apoptosis in endothelial cells. Increased expression of CD248 in SSc may contribute to the observed microvascular rarefaction at the tissue level. Our results suggest a pathogenic role for CD248-MMNR-2 in SSc.
Article
Environmental Sciences
Cara C. Schweitzer, Carolina A. Bonin, Christopher Magel, Thomas P. Hurst, Andrij Z. Horodysky
Summary: This study investigated the differential expression of miRNAs in Arctic cod exposed to elevated CO2 levels. It identified 17 miRNAs associated with reduced auditory performance, 12 of which showed significant differential expression in high CO2 conditions. Target gene predictions suggested these miRNAs are involved in inner ear maintenance, hair cell degradation, age-related hearing loss, neural inflammation, and injury.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Damon Fard, Luca Tamagnone
Summary: Semaphorins, a family of extracellular signaling molecules, play essential roles in cell communication and regulate various intracellular signaling pathways to influence development and tissue homeostasis. Their altered expression in numerous human diseases suggests potential significant medical relevance.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jose P. Martinho, Ana Coelho, Barbara Oliveiros, Salome Pires, Ana Margarida Abrantes, Siri Paulo, Ana Catarina Carvalho, Eunice Carrilho, Anabela Paula, Lina Carvalho, Raquel Seica, Maria Filomena Botelho, Carlos Miguel Marto, Gianrico Spagnuolo, Paulo Matafome, Manuel Marques Ferreira
Summary: The study found that diabetes has a significant impact on the success rate of root canal treatment, with diabetic patients having a significantly lower success rate than the control group. Diabetic rats in the experiment showed metabolic abnormalities and tissue damage.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Shujin Li, Mu Yang, Rulian Zhao, Li Peng, Wenjing Liu, Xiaoyan Jiang, Yunqi He, Erkuan Dai, Lin Zhang, Yeming Yang, Yi Shi, Peiquan Zhao, Zhenglin Yang, Xianjun Zhu
Summary: EMC is essential for the insertion of multi-transmembrane proteins and its dysfunction is associated with various diseases. In this study, the loss of EMC1 in endothelial cells led to defects in retinal vascularization. Further analysis revealed the involvement of EMC1 in the 13-catenin signaling pathway, which is crucial for proper vascular development. Variants in EMC1 gene may contribute to the pathogenesis of familial exudative vitreoretinopathy (FEVR) through compromised 13-catenin signaling activity.
Letter
Rheumatology
Cosimo Bruni, Marco Matucci-Cerinic
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas Landini, Martina Orlandi, Mariaelena Occhipinti, Cosimo Nardi, Lorenzo Tofani, Silvia Bellando-Randone, Pierluigi Ciet, Piotr Wielopolski, Thomas Benkert, Cosimo Bruni, Silvia Bertolo, Alberto Moggi-Pignone, Marco Matucci-Cerinic, Giovanni Morana, Stefano Colagrande
Summary: The purpose of this study was to test the application of respiratory-triggered ultrashort echo-time (UTE) Spiral VIBE-MRI sequence in the assessment of systemic sclerosis-interstitial lung disease (SSc-ILD) compared with computed tomography (CT). The results showed that the UTE sequence had high reliability in assessing the extent of ILD and GGO.
JOURNAL OF THORACIC IMAGING
(2023)
Article
Rheumatology
Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, Dilia Giuggioli, Mirko Manetti, Marco Matucci-Cerinic
Summary: Pharmacological sGC stimulation effectively improves the angiogenic performance and reduces the myofibroblast-like profibrotic phenotype of SSc-MVECs, providing new evidence for repurposing sGC stimulators for the treatment of SSc.
Article
Rheumatology
Alexandru Garaiman, Klaus Steigmiller, Catherine Gebhard, Carina Mihai, Rucsandra Dobrota, Cosimo Bruni, Marco Matucci-Cerinic, Joerg Henes, Jeska De Vries-Bouwstra, Vanessa Smith, Andrea Doria, Yannick Allanore, Lorenzo Dagna, Branimir Anic, Carlomaurizio Montecucco, Otylia Kowal-Bielecka, Mickael Martin, Yoshiya Tanaka, Anna-Maria Hoffmann-Vold, Ulrike Held, Oliver Distler, Mike Oliver Becker
Summary: The DU-VASC model was developed and validated to assist in decision-making for the management of digital ulcers in patients with systemic sclerosis. The model showed that PI treatment was the most important predictor associated with reduced occurrence of digital ulcers.
Article
Rheumatology
Cosimo Bruni, Mariaelena Occhipinti, Michael Pienn, Gianna Camiciottoli, Maurizio Bartolucci, Silvia Laura Bosello, Christian Payer, Zoltan Balint, Anna Rita Larici, Alessandra Tottoli, Lorenzo Tofani, Enrico De Lorenzis, Gemma Lepri, Silvia Bellando-Randone, Amelia Spinella, Dilia Giuggioli, Francesco Masini, Giovanna Cuomo, Federico Lavorini, Stefano Colagrande, Horst Olschewski, Marco Matucci-Cerinic
Summary: Recent advancements have made it possible to quantitatively assess lung vascular and parenchymal changes in thoracic CT images using automated software tools. In this study, the researchers investigated the vessel parameters of patients with SSc and correlated them with interstitial lung disease (ILD) features. The results showed that the CT vessel parameters increased in parallel with ILD extent and functional impairment, suggesting that they may serve as a biomarker of SSc-ILD severity.
Review
Rheumatology
Maria Ramona Melis, Khadija El Aoufy, Stefano Bambi, Cosimo Bruni, Serena Guiducci, Silvia Bellando-Randone, Marco Matucci-Cerinic, Laura Rasero
Summary: Investigating unmet needs and identifying necessary interventions for patients with rheumatic and musculoskeletal diseases (RMDs) is crucial for ensuring continuity and quality of chronic care. A systematic literature review was conducted to identify nursing interventions for RMD patients undergoing biological therapy. Thirteen articles met the inclusion criteria, and three major nursing interventions were identified: education, patient-centered care, and data collection/nurse monitoring, all of which were associated with improved care satisfaction and treatment adherence among patients.
CLINICAL RHEUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Eloisa Romano, Mirko Manetti
Summary: Systemic sclerosis (SSc, scleroderma) is a rare connective tissue disease characterized by immune dysregulation, small vessel vasculopathy, impaired angiogenesis, and fibrosis. Microvascular impairment is the initial event of the disease and is linked to disabling and life-threatening clinical manifestations. Despite available treatment options, managing SSc-related vascular disease remains challenging. Vascular biomarkers have shown promise in assessing disease progression, predicting prognosis, and guiding therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elena Andreucci, Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Alessio Biagioni, Eloisa Romano, Lido Calorini, Mirko Manetti
Summary: This study reveals a previously unrecognized relationship between lactic acidosis and the generation of a new CAF-like cell subpopulation from adipocytic precursor cells, which sustains tumor malignancy.
Editorial Material
Biology
Eloisa Romano, Irene Rosa, Mirko Manetti
Review
Rheumatology
Cosimo Bruni, Maya H. Buch, Aleksandra Djokovic, Giacomo De Luca, Raluca B. Dumitru, Alessandro Giollo, Ilaria Galetti, Alexia Steelandt, Konstantinos Bratis, Yossra Atef Suliman, Ivan Milinkovic, Anna Baritussio, Ghadeer Hasan, Anastasia Xintarakou, Yohei Isomura, George Markousis-Mavrogenis, Sophie Mavrogeni, Luna Gargani, Alida L. P. Caforio, Carsten Tschoepe, Arsen Ristic, Sven Plein, Elijah Behr, Yannick Allanore, Masataka Kuwana, Christopher P. Denton, Daniel E. Furst, Dinesh Khanna, Thomas Krieg, Renzo Marcolongo, Alessia Pepe, Oliver Distler, Petros Sfikakis, Petar Seferovic, Marco Matucci-Cerinic
Summary: The aim of this study was to establish consensus guidance on the screening, diagnosis, and follow-up of systemic sclerosis primary heart involvement. A systematic literature review was performed, and the extracted data were discussed to formulate overarching principles and guidance statements. The consensus emphasized the importance of patient counseling, differential diagnosis, multidisciplinary team management, and defining screening and diagnostic approaches. This guidance provides a foundation for standard of care and future feasibility studies.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Article
Cell Biology
Irene Rosa, Patrizia Nardini, Bianca Saveria Fioretto, Daniele Guasti, Eloisa Romano, Eleonora Sgambati, Mirca Marini, Mirko Manetti
Summary: Telocytes (TCs) have been found to exist in the stromal tissue of the human vaginal mucosa and are characterized by their presence in the perivascular networks and release of extracellular vesicles. Further investigation is needed to determine the functions of TCs in vaginal mucosal homeostasis and pathophysiology.
Article
Rheumatology
Weijin Zhang, Guohai Huang, Kedi Zheng, Jianqun Lin, Shijian Hu, Shaoyu Zheng, Guangzhou Du, Guohong Zhang, Cosimo Bruni, Marco Matucci-Cerinic, Daniel E. Furst, Yukai Wang
Summary: The study aimed to establish and use a machine learning algorithm to predict possible risk factors for malignancy in IIM patients. Age, ALT<80U/L, and anti-TIF1-gamma were found to be risk factors, while ILD was a protective factor in constructing the prediction model. Compared with other machine learning algorithm models, the logistic regression (LR) model performed well in predicting malignancy in IIM. The established prediction model helps clinicians screen, evaluate, and follow up high-risk IIM patients by constructing a diagnostic nomogram.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Letter
Rheumatology
Mirko Manetti
ANNALS OF THE RHEUMATIC DISEASES
(2023)