What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

Isolation and clinical sample typing of human leptospirosis cases in Argentina

(2016) Yosena Chiani et al.   INFECTION GENETICS AND EVOLUTION

Multi -omics and metabolic modelling pipelines: Challenges and tools for systems microbiology

(2015) Marco Fondi et al.   MICROBIOLOGICAL RESEARCH

Analysis of the chemotactic behaviour ofLeptospirausing microscopic agar-drop assay

(2014) Md. Shafiqul Islam et al.   FEMS MICROBIOLOGY LETTERS

International Committee on Systematics of Prokaryotes * Subcommittee on the taxonomy of Leptospiraceae: Minutes of the closed meeting, 9 October 2013, Fukuoka, Japan

(2014) P. N. Levett et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Leptospira mayottensis sp. nov., a pathogenic species of the genus Leptospira isolated from humans

(2014) P. Bourhy et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Optimizing genome-scale network reconstructions

(2014) Jonathan Monk et al.   NATURE BIOTECHNOLOGY

Constraint-based models predict metabolic and associated cellular functions

(2014) Aarash Bordbar et al.   NATURE REVIEWS GENETICS

Identification of Cell-Binding Adhesins of Leptospira interrogans

(2014) Karen V. Evangelista et al.   PLoS Neglected Tropical Diseases

Leptospira interrogans Binds to Cadherins

(2014) Karen Evangelista et al.   PLoS Neglected Tropical Diseases

Characterization of Three Novel Adhesins of Leptospira interrogans

(2013) Gabriela H. Siqueira et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

COBRApy: COnstraints-Based Reconstruction and Analysis for Python

(2013) Ali Ebrahim et al.   BMC Systems Biology

Leptospiral extracellular matrix adhesins as mediators of pathogen-host interactions

(2013) Monica L. Vieira et al.   FEMS MICROBIOLOGY LETTERS

Evolution of Pan-Genomes of Escherichia coli, Shigella spp., and Salmonella enterica

(2013) E. N. Gordienko et al.   JOURNAL OF BACTERIOLOGY

Iron regulation by hepcidin

(2013) Ningning Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Collagenase as a Critical Virulence Factor for Invasiveness and Transmission of Pathogenic Leptospira Species

(2013) Kokouvi Kassegne et al.   JOURNAL OF INFECTIOUS DISEASES

Immune Evasion by Pathogenic Leptospira Strains: The Secretion of Proteases that Directly Cleave Complement Proteins

(2013) Tatiana Rodrigues Fraga et al.   JOURNAL OF INFECTIOUS DISEASES

In vivo gene expression and immunoreactivity of Leptospira collagenase

(2013) Weena Janwitthayanan et al.   MICROBIOLOGICAL RESEARCH

Functional and immunological evaluation of two novel proteins of Leptospira spp.

(2013) L. G. V. Fernandes et al.   MICROBIOLOGY-SGM

Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments

(2013) J. M. Monk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesins of Leptospira interrogans Mediate the Interaction to Fibrinogen and Inhibit Fibrin Clot Formation In Vitro

(2013) Rosane Oliveira et al.   PLoS Neglected Tropical Diseases

Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans

(2013) Jason S. Lehmann et al.   PLoS Neglected Tropical Diseases

A Single Multilocus Sequence Typing (MLST) Scheme for Seven Pathogenic Leptospira Species

(2013) Siriphan Boonsilp et al.   PLoS Neglected Tropical Diseases

Serovar Diversity of Pathogenic Leptospira Circulating in the French West Indies

(2013) Pascale Bourhy et al.   PLoS Neglected Tropical Diseases

Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain

(2012) Suneth B. Agampodi et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The Unique Paradigm of Spirochete Motility and Chemotaxis

(2012) Nyles W. Charon et al.   Annual Review of Microbiology

Chemotactic Behavior of Pathogenic and Nonpathogenic Leptospira Species

(2012) Ambroise Lambert et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Protease-dependent mechanisms of complement evasion by bacterial pathogens

(2012) Michal Potempa et al.   BIOLOGICAL CHEMISTRY

Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens

(2012) Jihye Park et al.   BMC GENOMICS

Expression of sialic acids and other nonulosonic acids in Leptospira

(2012) Jessica Ricaldi N et al.   BMC MICROBIOLOGY

“Features of two proteins of Leptospira interrogans with potential role in host-pathogen interactions”

(2012) Renan F Domingos et al.   BMC MICROBIOLOGY

Extra cytoplasmic function σ factor activation

(2012) Theresa D Ho et al.   CURRENT OPINION IN MICROBIOLOGY

Sequence of Leptospira santarosai serovar Shermani genome and prediction of virulence-associated genes

(2012) Li-Fang Chou et al.   GENE

FlaA Proteins in Leptospira interrogans Are Essential for Motility and Virulence but Are Not Required for Formation of the Flagellum Sheath

(2012) Ambroise Lambert et al.   INFECTION AND IMMUNITY

OmpL1 Is an Extracellular Matrix- and Plasminogen-Interacting Protein of Leptospira spp.

(2012) Luis G. V. Fernandes et al.   INFECTION AND IMMUNITY

Leptospira idonii sp. nov., isolated from environmental water

(2012) M. Saito et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Species Revealed by Cryo-Electron Tomography

(2012) G. Raddi et al.   JOURNAL OF BACTERIOLOGY

Leptospiral Outer Membrane Protein Microarray, a Novel Approach to Identification of Host Ligand-Binding Proteins

(2012) M. Pinne et al.   JOURNAL OF BACTERIOLOGY

Plasminogen Binding Proteins and Plasmin Generation on the Surface ofLeptospiraspp.: The Contribution to the Bacteria-Host Interactions

(2012) Monica L. Vieira et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

(2012) Mónica Marcela Castiblanco-Valencia et al.   JOURNAL OF INFECTIOUS DISEASES

Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa

(2012) Nicholas A Feasey et al.   LANCET

Lsa30, a novel adhesin of Leptospira interrogans binds human plasminogen and the complement regulator C4bp

(2012) Natalie M. Souza et al.   MICROBIAL PATHOGENESIS

Vitamin B12 transport from food to the body's cells—a sophisticated, multistep pathway

(2012) Marianne J. Nielsen et al.   Nature Reviews Gastroenterology & Hepatology

New and continuing developments at PROSITE

(2012) Christian J. A. Sigrist et al.   NUCLEIC ACIDS RESEARCH

PanOCT: automated clustering of orthologs using conserved gene neighborhood for pan-genomic analysis of bacterial strains and closely related species

(2012) Derrick E. Fouts et al.   NUCLEIC ACIDS RESEARCH

TIGRFAMs and Genome Properties in 2013

(2012) Daniel H. Haft et al.   NUCLEIC ACIDS RESEARCH

Multiple Activities of LigB Potentiate Virulence of Leptospira interrogans: Inhibition of Alternative and Classical Pathways of Complement

(2012) Henry A. Choy   PLoS One

Whole Genome Analysis of Leptospira licerasiae Provides Insight into Leptospiral Evolution and Pathogenicity

(2012) Jessica N. Ricaldi et al.   PLoS Neglected Tropical Diseases

Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence

(2011) Yuansha Chen et al.   BMC GENOMICS

Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

(2011) Jeremiah J Davie et al.   BMC GENOMICS

Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin

(2011) Cláudio Figueira et al.   BMC MICROBIOLOGY

Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages

(2011) Claudia Toma et al.   CELLULAR MICROBIOLOGY

The Novel Leptospiral Surface Adhesin Lsa20 Binds Laminin and Human Plasminogen and Is Probably Expressed during Infection

(2011) Renata Siqueira Mendes et al.   INFECTION AND IMMUNITY

Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage

(2011) Chris L Dupont et al.   ISME Journal

Analysis of Multilocus Sequence Typing for Identification of Leptospira Isolates in Brazil : Table 1.

(2011) E. C. Romero et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Staphylococcus aureus Metalloprotease Aureolysin Cleaves Complement C3 To Mediate Immune Evasion

(2011) A. J. Laarman et al.   JOURNAL OF IMMUNOLOGY

The Salmonella enterica Pan-genome

(2011) Annika Jacobsen et al.   MICROBIAL ECOLOGY

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Evolution and classification of the CRISPR–Cas systems

(2011) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

The Multifunctional LigB Adhesin Binds Homeostatic Proteins with Potential Roles in Cutaneous Infection by Pathogenic Leptospira interrogans

(2011) Henry A. Choy et al.   PLoS One

Characterization of Novel OmpA-Like Protein of Leptospira interrogans That Binds Extracellular Matrix Molecules and Plasminogen

(2011) Rosane Oliveira et al.   PLoS One

Contribution of TAT System Translocated PhoX to Campylobacter jejuni Phosphate Metabolism and Resilience to Environmental Stresses

(2011) Mary Drozd et al.   PLoS One

Comparison of Two Multilocus Sequence Based Genotyping Schemes for Leptospira Species

(2011) Ahmed Ahmed et al.   PLoS Neglected Tropical Diseases

Leptospiraas an emerging pathogen: a review of its biology, pathogenesis and host immune responses

(2010) Karen V Evangelista et al.   Future Microbiology

Functional Characterization of LcpA, a Surface-Exposed Protein of Leptospira spp. That Binds the Human Complement Regulator C4BP

(2010) A. S. Barbosa et al.   INFECTION AND IMMUNITY

High-throughput generation, optimization and analysis of genome-scale metabolic models

(2010) Christopher S Henry et al.   NATURE BIOTECHNOLOGY

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Genetic Affinities within a Large Global Collection of Pathogenic Leptospira: Implications for Strain Identification and Molecular Epidemiology

(2010) Kishore Nalam et al.   PLoS One

A Catalog of Reference Genomes from the Human Microbiome

(2010) et al.   SCIENCE

Standard operating procedure for calculating genome-to-genome distances based on high-scoring segment pairs

(2010) Alexander F. Auch et al.   Standards in Genomic Sciences

Digital DNA-DNA hybridization for microbial species delineation by means of genome-to-genome sequence comparison

(2010) Alexander F. Auch et al.   Standards in Genomic Sciences

Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira

(2010) Christian A. Ganoza et al.   PLoS Neglected Tropical Diseases

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

(2009) S. Capella-Gutierrez et al.   BIOINFORMATICS

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai

(2009) Sumei Liao et al.   BMC MICROBIOLOGY

The CMP-legionaminic acid pathway in Campylobacter: Biosynthesis involving novel GDP-linked precursors

(2009) Ian C Schoenhofen et al.   GLYCOBIOLOGY

A century of Leptospira strain typing

(2009) Gustavo M. Cerqueira et al.   INFECTION GENETICS AND EVOLUTION

Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin

(2009) Shijun Li et al.   Innate Immunity

Notes on the characterization of prokaryote strains for taxonomic purposes

(2009) B. J. Tindall et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Lsa63, a newly identified surface protein of Leptospira interrogans binds laminin and collagen IV

(2009) Monica L. Vieira et al.   JOURNAL OF INFECTION

A newly identified protein of Leptospira interrogans mediates binding to laminin

(2009) M. T. Longhi et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Distribution of the leptospiral immunoglobulin-like (lig) genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolates

(2009) G. M. Cerqueira et al.   JOURNAL OF MEDICAL MICROBIOLOGY

A molecular ruler mechanism for length control of extended protein structures in bacteria

(2009) J.P. Keener   JOURNAL OF THEORETICAL BIOLOGY

LipL53, a temperature regulated protein from Leptospira interrogans that binds to extracellular matrix molecules

(2009) Tatiane R. Oliveira et al.   MICROBES AND INFECTION

Pivotal Roles of the Outer Membrane Polysaccharide Export and Polysaccharide Copolymerase Protein Families in Export of Extracellular Polysaccharides in Gram-Negative Bacteria

(2009) L. Cuthbertson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family

(2009) Anna Staroń et al.   MOLECULAR MICROBIOLOGY

Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans

(2009) Johan Malmström et al.   NATURE

Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen

(2009) Albert I. Ko et al.   NATURE REVIEWS MICROBIOLOGY

The comprehensive microbial resource

(2009) Tanja Davidsen et al.   NUCLEIC ACIDS RESEARCH

Shifting the genomic gold standard for the prokaryotic species definition

(2009) Michael Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome Project Standards in a New Era of Sequencing

(2009) P. S. G. Chain et al.   SCIENCE

GrowMatch: An Automated Method for Reconciling In Silico/In Vivo Growth Predictions

(2009) Vinay Satish Kumar et al.   PLoS Computational Biology

PSAT: A web tool to compare genomic neighborhoods of multiple prokaryotic genomes

(2008) Christine Fong et al.   BMC BIOINFORMATICS

The Thermolysin Family (M4) of Enzymes: Therapeutic and Biotechnological Potential

(2008) Olayiwola A. Adekoya et al.   Chemical Biology & Drug Design

Comparative genomics: the bacterial pan-genome

(2008) Hervé Tettelin et al.   CURRENT OPINION IN MICROBIOLOGY

Identification of a Novel Prophage-Like Gene Cluster Actively Expressed in Both Virulent and Avirulent Strains of Leptospira interrogans Serovar Lai

(2008) J.-H. Qin et al.   INFECTION AND IMMUNITY

Immune Evasion of Leptospira Species by Acquisition of Human Complement Regulator C4BP

(2008) A. S. Barbosa et al.   INFECTION AND IMMUNITY

Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp.

(2008) Alan J.A. McBride et al.   INFECTION GENETICS AND EVOLUTION

The Pangenome Structure of Escherichia coli: Comparative Genomic Analysis of E. coli Commensal and Pathogenic Isolates

(2008) D. A. Rasko et al.   JOURNAL OF BACTERIOLOGY

Rapid autocatalytic activation of the M4 metalloprotease aureolysin is controlled by a conserved N-terminal fungalysin-thermolysin-propeptide domain

(2008) Nicholas N. Nickerson et al.   MOLECULAR MICROBIOLOGY

The Ribosomal Database Project: improved alignments and new tools for rRNA analysis

(2008) J. R. Cole et al.   NUCLEIC ACIDS RESEARCH

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

(2008) Mathieu Picardeau et al.   PLoS One

Complete Genome Sequence of the N2-Fixing Broad Host Range Endophyte Klebsiella pneumoniae 342 and Virulence Predictions Verified in Mice

(2008) Derrick E. Fouts et al.   PLoS Genetics

Household Transmission of Leptospira Infection in Urban Slum Communities

(2008) Elves A. P. Maciel et al.   PLoS Neglected Tropical Diseases

Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon

(2008) Michael A. Matthias et al.   PLoS Neglected Tropical Diseases

CMP-Pseudaminic Acid is a Natural Potent Inhibitor of PseB, the First Enzyme of the Pseudaminic Acid Pathway inCampylobacter jejuni andHelicobacter pylori

(2007) David J. McNally et al.   ChemMedChem