Article
Immunology
Ajay Kumar, Vivek P. Varma, Kavela Sridhar, Mohd Abdullah, Pallavi Vyas, Muhammed Ashiq Thalappil, Yung-Fu Chang, Syed M. Faisal
Summary: The study identified the domain A(11) of Leptospira immunoglobulin-like protein A (LAV) as playing a crucial role in modulating host immune responses, leading to persistent infection in different hosts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Ajay Kumar, Vivek P. Varma, Syed M. Faisal
Summary: The study shows that certain surface proteins in Leptospira are involved in immune modulation and play a critical role in assisting the bacteria in invading and colonizing the host tissue for persistent infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Brenda B. Daroz, Luis G. V. Fernandes, Maria F. Cavenague, Leandro T. Kochi, Felipe J. Passalia, Maria B. Takahashi, Edson G. Nascimento Filho, Aline F. Teixeira, Ana L. T. O. Nascimento
Summary: Leptospirosis is a widespread zoonotic disease of human and veterinary concern caused by pathogenic Leptospira spp. Investigating surface proteins of the bacterium provides insights into host-pathogen interactions for better understanding of the mechanisms involved.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Beatriz Takahashi, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento
Summary: This study aimed to investigate the adhesion of different Leptospira strains and outer membrane proteins to various cell lines, shedding light on the interaction between Leptospira and mammalian cells and providing insights into the pathogenesis of leptospirosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Niranjana Nair, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan, Chittappen Kandiyil Prajeeth
Summary: Rift Valley Fever Virus is a mosquito-borne phlebovirus that causes febrile or haemorrhagic illness in ruminants and humans. The virus can prevent the induction of the antiviral interferon response through its NSs proteins. Mutations in the NSs gene may lead to the induction of innate proinflammatory immune responses and attenuation of the virus. Virus-specific antibodies and T cells are induced upon infection, which may provide protection against subsequent infections. These findings will help in the development of vaccines using existing platforms. Vaccines candidates have shown promise in safety and efficacy trials in susceptible animal species, which may contribute to controlling RVFV infections and preventing disease progression in humans and ruminants.
Article
Ecology
Abdul Arif Khan, Fozia Farooq, Sudhir K. Jain, Patrycja Golinska, Mahendra Rai
Summary: COVID-19 has caused a global catastrophe, with an increased occurrence of invasive pulmonary aspergillosis infection in patients, even in the absence of traditional risk factors. Further research is needed to explore the mechanism between SARS-CoV2 and aspergillosis in order to better address these diseases.
Article
Entomology
Qinjian Pan, Ikkei Shikano, Gary W. Felton, Tong-Xian Liu, Kelli Hoover
Summary: Insects exhibit diverse immune responses and developmental costs when combating different baculoviruses, highlighting the complexity of host-pathogen interactions.
Article
Immunology
Jhalak Singhal, Evanka Madan, Ayushi Chaurasiya, Pallavi Srivastava, Niharika Singh, Shikha Kaushik, Amandeep Kaur Kahlon, Mukesh Kumar Maurya, Manisha Marothia, Prerna Joshi, Anand Ranganathan, Shailja Singh
Summary: SUMOylation is involved in the infection process of Leishmania donovani by hijacking the host immune responses and facilitating host autophagy. Targeting the SUMOylation pathway may provide a potential therapeutic intervention for leishmaniasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Kumari Snehkant Lata, Swapnil Kumar, Vaibhav Vindal, Saumya Patel, Jayashankar Das
Summary: This study explores the pan-genome of Leptospira genus, revealing the functional features and interactions with human proteins. The phylogenetic analysis based on the pan-genome separates Leptospira into three major clades related to their pathogenicity. Furthermore, specific genes for pathogenic and saprophytic groups have been identified and functionally annotated. These findings provide new insights into the genomic features of Leptospira and are valuable for disease control.
MICROBIAL PATHOGENESIS
(2022)
Review
Biochemistry & Molecular Biology
Anuja Jain, Shikha Mittal, Lokesh P. Tripathi, Ruth Nussinov, Shandar Ahmad
Summary: Recognition of pathogen-derived nucleic acids by host cells is crucial for detecting pathogenic invasion and triggering immune responses. Understanding the interactions between pathogen nucleic acids and host factors is essential for therapeutic intervention.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Immunology
Aryashree Arunima, Erin J. van Schaik, James E. Samuel
Summary: Long non-coding RNAs (lncRNAs) are conserved non-coding regulatory transcripts that play a role in various biological processes. They regulate chromatin function and mRNA stability and translation. Increasing evidence suggests that lncRNAs are involved in immune responses, microbiome development, and diseases such as neurological disorders, cancer, and infections. This review discusses the regulatory roles of lncRNAs in immune responses, host-microbe interactions, and bacterial infections. The study of lncRNAs is important for the development of alternative therapies for severe infections and the diagnosis and prognosis of human diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Felipe Jose Passalia, Marcos Bryan Heinemann, Monica Larucci Vieira, Ana Lucia T. O. Nascimento
Summary: The study describes a novel leptospiral protein LIC13086, which may play a multifunctional role in adhesion, dissemination, and immune evasion during infection, showing potential in leptospiral pathogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Alfonso Olaya-Abril, Rafael Prados-Rosales, Jose A. Gonzalez-Reyes, Arturo Casadevall, Liise-anne Pirofski, Manuel J. Rodriguez-Ortega
Summary: This study demonstrates that extracellular vesicles produced by different serotypes of Streptococcus pneumoniae can be internalized by macrophages through fusion with host cell membranes, and have the ability to induce an immune response and promote the production of proinflammatory cytokines, with higher levels observed in certain serotypes.
Article
Immunology
Ali Salimi-Jeda, Sina Abbassi, Atieh Mousavizadeh, Maryam Esghaie, Farah Bokharaei-Salim, Farhad Jeddi, Maryam Shafaati, Asghar Abdoli
Summary: Despite over a year since the SARS-CoV-2 pandemic, COVID-19 continues to pose a major global challenge for scientists, with the cytokine storm from the immune response being a key factor in disease severity. Global efforts to control SARS-CoV-2 face obstacles such as viral mutations, short immunity duration, and the potential for reinfection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)