Iron regulation by hepcidin

Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2

(2013) Eva Maurer et al.   BIOCHEMICAL JOURNAL

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

(2012) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region

(2012) Eva Maurer et al.   BIOLOGICAL CHEMISTRY

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

(2012) E. Ramos et al.   BLOOD

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum

(2012) W. Chen et al.   HAEMATOLOGICA

Neogenin Interacts with Matriptase-2 to Facilitate Hemojuvelin Cleavage

(2012) Caroline A. Enns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis

(2012) Luca Valenti et al.   JOURNAL OF HEPATOLOGY

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

SALIVA IRON AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA AND IRON DEFICIENCY ANEMIA

(2012) Duran Canatan et al.   Mediterranean Journal of Hematology and Infectious Diseases

Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemia

(2011) Susanne van Santen et al.   ARTHRITIS AND RHEUMATISM

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

(2011) W. Chen et al.   BLOOD

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

Dispersion of repolarization and beta-thalassemia major: the prognostic role of QT and JT dispersion for identifying the high-risk patients for sudden death

(2011) Vincenzo Russo et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

(2011) Elena Corradini et al.   GASTROENTEROLOGY

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

(2011) M. Mastrogiannaki et al.   HAEMATOLOGICA

Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin

(2011) Konstantinos Gkouvatsos et al.   HEPATOLOGY

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Development of a nano-liquid chromatography on chip tandem mass spectrometry method for high-sensitivity hepcidin quantitation

(2011) V. Houbart et al.   JOURNAL OF CHROMATOGRAPHY A

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

The Molecular Pathogenesis of Hereditary Hemochromatosis

(2011) Jodie Babitt et al.   SEMINARS IN LIVER DISEASE

AG490: An inhibitor of hepcidin expressionin vivo

(2011) Shu-Ping Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys

(2010) Jim J. Xiao et al.   AAPS Journal

Hepcidin in β-thalassemia

(2010) Elizabeta Nemeth   Annals of the New York Academy of Sciences

Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

(2010) A. Lenoir et al.   BLOOD

Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo

(2010) M. Poli et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

(2010) S.-N. J. Song et al.   BLOOD

Immunochemical and Mass-Spectrometry-Based Serum Hepcidin Assays for Iron Metabolism Disorders

(2010) J. J. C. Kroot et al.   CLINICAL CHEMISTRY

BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

(2010) Elena Corradini et al.   GASTROENTEROLOGY

Serum hepcidin-25 may replace the ferritin index in the Thomas plot in assessing iron status in anemic patients

(2010) C. THOMAS et al.   International Journal of Laboratory Hematology

Soluble Repulsive Guidance Molecule c/Hemojuvelin Is a Broad Spectrum Bone Morphogenetic Protein (BMP) Antagonist and Inhibits both BMP2- and BMP6-mediated Signaling and Gene Expression

(2010) Mahta Nili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors

(2010) Samira Lakhal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expressionin Vivo

(2010) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel monoclonal antibody immunoassay for the detection of human serum hepcidin

(2010) Peggy Schwarz et al.   JOURNAL OF GASTROENTEROLOGY

Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form

(2010) Nadia Fatih et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation

(2010) Toshihiko Tanno et al.   TRANSFUSION

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

(2009) D. R. Ashby et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

A Novel Immunological Assay for Hepcidin Quantification in Human Serum

(2009) Vasiliki Koliaraki et al.   PLoS One

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin

(2008) David Kuninger et al.   BMC BIOCHEMISTRY

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

Advances in Quantitative Hepcidin Measurements by Time-of-Flight Mass Spectrometry

(2008) Dorine W. Swinkels et al.   PLoS One

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Regulation of iron acquisition and storage: consequences for iron-linked disorders

(2007) Ivana De Domenico et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY