Reactivation of telomerase in cancer

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

Quantitative assessment of telomerase components in cancer cell lines

(2015) Semih Can Akıncılar et al.   FEBS LETTERS

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

(2015) Cheryl M. Koh et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

(2015) Yinghui Li et al.   NATURE CELL BIOLOGY

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

(2014) Yinghui Li et al.   CANCER RESEARCH

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

(2014) Roger Reddel   CURRENT PHARMACEUTICAL DESIGN

DEAD-box helicase DP103 defines metastatic potential of human breast cancers

(2014) Eun Myoung Shin et al.   JOURNAL OF CLINICAL INVESTIGATION

TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma

(2014) Klaus G. Griewank et al.   JNCI-Journal of the National Cancer Institute

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours

(2013) K G Griewank et al.   BRITISH JOURNAL OF CANCER

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Comprehensive Mutation Analysis of the TERT Promoter in Bladder Cancer and Detection of Mutations in Voided Urine

(2013) Carolyn D. Hurst et al.   EUROPEAN UROLOGY

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

(2013) Zsofia Kote-Jarai et al.   HUMAN MOLECULAR GENETICS

Association Between BRAF V600E Mutation and Mortality in Patients With Papillary Thyroid Cancer

(2013) Mingzhao Xing et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Frequent SomaticTERTPromoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease

(2013) Iñigo Landa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Structure of active dimeric human telomerase

(2013) Anselm Sauerwald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

(2013) Mandy S. Wong et al.   Cell Reports

Epidemiology and Risk Factors of Urothelial Bladder Cancer

(2012) Maximilian Burger et al.   EUROPEAN UROLOGY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation

(2012) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

Wnt Regulates TERT--Putting the Horse Before the Cart

(2012) C. W. Greider   SCIENCE

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Hexamethylene Bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF-κB activity: Implications for cancer therapy

(2010) Anwesha Dey et al.   CELL CYCLE

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers

(2010) Michael Jansen et al.   LANCET NEUROLOGY

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

(2010) Jiyue Zhu et al.   Protein & Cell

Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity

(2009) Lili Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase

(2009) Zheng Ge et al.   FASEB JOURNAL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc

(2008) Dakang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

(2008) T. Vulliamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA