Inhibition of Telomerase Recruitment and Cancer Cell Death

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

Highly prevalentTERTpromoter mutations in bladder cancer and glioblastoma

(2013) Xiaoli Liu et al.   CELL CYCLE

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme

(2012) Alec N. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

(2010) Chrysa M Latrick et al.   EMBO JOURNAL

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics