DNMT3A in Leukemia

DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation

(2016) Jae-Sook Ahn et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

(2016) Liubin Yang et al.   CANCER CELL

DNMT3A R882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

(2016) L Scourzic et al.   LEUKEMIA

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

(2016) Xiaotian Zhang et al.   NATURE GENETICS

Assessment of Minimal Residual Disease in Standard-Risk AML

(2016) Adam Ivey et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation

(2016) Junji Koya et al.   Nature Communications

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

(2016) S. E. Meyer et al.   Cancer Discovery

How I treat mixed-phenotype acute leukemia

(2015) O. Wolach et al.   BLOOD

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

(2015) Dmitry Borkin et al.   CANCER CELL

DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia

(2015) A. R. Sehgal et al.   CLINICAL CANCER RESEARCH

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

(2015) J. Nangalia et al.   HAEMATOLOGICA

Distribution of mutations in DNMT3A gene and the suitability of mutations in R882 codon for MRD monitoring in patients with AML

(2015) Ivana Jeziskova et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

(2015) Jeffery M. Klco et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia

(2015) Kristen Meldi et al.   JOURNAL OF CLINICAL INVESTIGATION

Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia

(2015) Rosemary E. Gale et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

(2015) Jing Liao et al.   NATURE GENETICS

Genomic landscape of cutaneous T cell lymphoma

(2015) Jaehyuk Choi et al.   NATURE GENETICS

The genomic landscape of juvenile myelomonocytic leukemia

(2015) Elliot Stieglitz et al.   NATURE GENETICS

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

(2015) Tetsuichi Yoshizato et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

(2015) Thomas McKerrell et al.   Cell Reports

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

(2015) J. Nangalia et al.   HAEMATOLOGICA

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

(2014) H. Celik et al.   BLOOD

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

(2014) A. Mayle et al.   BLOOD

Persistence ofDNMT3Amutations at long-term remission in adult patients with AML

(2014) Gro G. Pløen et al.   BRITISH JOURNAL OF HAEMATOLOGY

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

(2014) David A. Russler-Germain et al.   CANCER CELL

Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding

(2014) Juncheng Wang et al.   CELL RESEARCH

Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells

(2014) Grant A. Challen et al.   Cell Stem Cell

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated byDNMT3Amutational status and associated with predominant hypomethylation of HOX genes

(2014) Ying Qu et al.   Epigenetics

Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase

(2014) Max Emperle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The emerging roles of DOT1L in leukemia and normal development

(2014) C M McLean et al.   LEUKEMIA

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

(2014) Fang Cao et al.   MOLECULAR CELL

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

(2014) Xue Guo et al.   NATURE

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

(2014) Katrina Tatton-Brown et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)

(2013) V. I. Gaidzik et al.   BLOOD

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

(2013) M. Neumann et al.   BLOOD

Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

(2013) P. Van Vlierberghe et al.   BLOOD

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

(2013) S. J. Kim et al.   BLOOD

Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A

(2013) D.-C. Liang et al.   BLOOD

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations inRUNX1andDNMT3Aare associated with poor prognosis in T-ALL

(2013) Vera Grossmann et al.   GENES CHROMOSOMES & CANCER

Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms

(2013) F Traina et al.   LEUKEMIA

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice

(2013) A Mupo et al.   LEUKEMIA

Landmark analysis of DNMT3A mutations in hematological malignancies

(2013) A Roller et al.   LEUKEMIA

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

(2013) T Haferlach et al.   LEUKEMIA

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

Large conserved domains of low DNA methylation maintained by Dnmt3a

(2013) Mira Jeong et al.   NATURE GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

(2012) A. F. T. Ribeiro et al.   BLOOD

DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transition

(2012) N. Hu et al.   GENES & DEVELOPMENT

Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation

(2012) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-Related Prognostic Impact of Different Types ofDNMT3AMutations in Adults With Primary Cytogenetically Normal Acute Myeloid Leukemia

(2012) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes

(2012) Rafael Bejar et al.   JOURNAL OF CLINICAL ONCOLOGY

Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells

(2012) Zhourui Wu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association

(2012) A Renneville et al.   LEUKEMIA

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

TET2andDNMT3AMutations in Human T-Cell Lymphoma

(2012) Lucile Couronné et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a

(2011) Isao Suetake et al.   BIOCHEMICAL JOURNAL

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A

(2011) A. M. Jankowska et al.   BLOOD

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

(2011) Y. Shen et al.   BLOOD

DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications

(2011) H.-A. Hou et al.   BLOOD

DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia

(2011) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin

(2011) S. Chantalat et al.   GENOME RESEARCH

DNMT3A mutations are rare in childhood acute myeloid leukemia

(2011) F. Thol et al.   HAEMATOLOGICA

Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia

(2011) I. Fried et al.   HAEMATOLOGICA

Rare occurrence of DNMT3A mutations in myelodysplastic syndromes

(2011) F. Thol et al.   HAEMATOLOGICA

Oligomerization of DNMT3A Controls the Mechanism ofde NovoDNA Methylation

(2011) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization and Binding of the Dnmt3a DNA Methyltransferase to Parallel DNA Molecules

(2011) Renata Z. Jurkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

DNMT3A mutations in myeloproliferative neoplasms

(2011) F Stegelmann et al.   LEUKEMIA

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

(2011) M J Walter et al.   LEUKEMIA

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group

(2011) Phoenix A. Ho et al.   PEDIATRIC BLOOD & CANCER

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression

(2011) Q. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML

(2010) T. A. Paul et al.   BLOOD

DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors

(2010) Md. Mustafizur Rahman et al.   HUMAN PATHOLOGY

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution

(2009) Yingying Zhang et al.   PLoS Genetics