期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 22, 期 1, 页码 61-70出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2015.07.030
关键词
Acute myeloid leukemia; TET2; IDH1/2; DNMT3A; Allogeneic hematopoietic cell transplantation; Normal karyotype
资金
- National Project for Personalized Genomic Medicine, Ministry for Health & Welfare, Republic of Korea [A111218-11-GM06]
- Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology (MEST) [NRF-2011-0030034]
- Research Institute of Medical Sciences, Chonnam National University [2015-CURIMS-DR004]
The prognostic relevance of epigenetic modifying genes (DNMT3A, TET2, and IDH1/2) in patients with acute myeloid leukemia (AML) has been investigated extensively. However, the prognostic implications of these mutations after allogeneic hematopoietic cell transplantation (HCT) have not been evaluated comprehensively in patients with normal-karyotype (NK)-AML. A total of 115 patients who received allogeneic HCT for NK-AML were retrospectively evaluated for the FLT3-ITD, NPM1, CEBPA, DNMT3A, TET2, IDH1/2, WT1, NRAS, ASXL2, FAT1, DNAH11, and GATA2 mutations in diagnostic samples and analyzed for long-term outcomes after allogeneic HCT. The prevalence rates for the mutations were as follows: FLT3-ITD positivity (FLT3-ITDPos) (32.2%), NPM1 mutation (43.5%), CEBPA mutation (double) (24.6%), DNMT3A mutation (DNMT3A(mut)) (313%), DNMT3A R882(mut) (18.3%), TET2 mutation (8.7%), and IDH1/2 mutation (16.5%). The 5-year overall survival (OS) and event-free survival (EFS) rates were 57.3% and 58.1%, respectively. A multivariate analysis revealed that FLT3-ITDPos (hazard ratio, [HR], 2.23; P =.006) and DNMT3A R882(mut) (HR, 2.74; P = .002) were unfavorable prognostic factors for OS. In addition, both mutations were significant risk factors for EFS and relapse. People with DNMT3A R882mut accompanied by FLT3-ITDPos had worse OS and EFS, and higher relapse rates than those with the other mutations, which were confirmed in a propensity score 1:2 matching analysis. These results suggest that DNMT3A R882(mut), particularly when accompanied by FLT3-1TD(Pos,) is a significant prognostic factor for inferior transplantation survival outcome by increasing relapse risk, even after allogeneic HCT. (C) 2016 American Society for Blood and Marrow Transplantation.
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