Article
Cell Biology
Anne-Charlotte Le Floch, Marie-Sarah Rouviere, Nassim Salem, Amira Ben Amara, Florence Orlanducci, Norbert Vey, Laurent Gorvel, Anne-Sophie Chretien, Daniel Olive
Summary: This study explored the impact of circulating ?d T-cell alterations on prognosis in newly diagnosed adult ALL patients. They found common alterations in CD8(+) T cells and ?d T cells of relapsed patients, including accumulation of early stage differentiation and increased expression of BTLA and CD73. The circulating ?d T-cell signature and Vd2 T-cell alterations were found to strongly discriminate patients by relapse status. These findings suggest the importance of Gd T cells, especially Vd2 T cells, in T-cell immunity and provide a rationale for further monitoring and enhancing Vd2 T cells in ALL.
Review
Oncology
Tina Kuenz, Alexander W. Hauswirth, Gabriele Hetzenauer, Jakob Rudzki, David Nachbaur, Normann Steiner
Summary: Improved understanding of acute lymphoblastic leukemia has led to new treatment strategies, including measurable residual disease assessment and allogeneic stem cell transplantation. Novel therapeutic opportunities, such as tyrosine-kinase inhibitors and CAR-T cells, aim to improve clinical outcomes. Despite advancements, acute lymphoblastic leukemia remains a challenging and life-threatening disease.
Article
Oncology
Jay Singh, Sarita Kumari, Mohit Arora, Deepak Verma, Jayanth Kumar Palanichamy, Rajive Kumar, Gunjan Sharma, Sameer Bakhshi, Deepam Pushpam, M. Shadab Ali, Amar Ranjan, Pranay Tanwar, Shyam S. Chauhan, Archna Singh, Anita Chopra
Summary: The study identified a potential role of EMP1, CASP1, and NLRP3 genes in prednisolone response in pediatric B-ALL patients. Expression levels of EMP1 were found to be significantly higher in prednisolone poor responders, especially in the BCR-ABL subtype. High CASP1 and NLRP3 expression were associated with a better prognosis in pediatric B-ALL patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Oncology
Hua Yin, Mei Hong, Jun Deng, Lan Yao, Chenjing Qian, Yao Teng, Tingting Li, Qiuling Wu
Summary: By analyzing gene mutations and clinical characteristics of adult T-cell acute lymphoblastic leukemia/lymphoma patients, three new risk stratification models were established. These models have a good prognostic role in guiding personalized treatment and improving patient outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Marcela B. Mansur, Caroline L. Furness, Sirintra Nakjang, Amir Enshaei, Donat Alpar, Sue M. Colman, Lynne Minto, Julie Irving, Beth V. Poole, Elda P. Noronha, Suvi Savola, Sameena Iqbal, John Gribben, Maria S. Pombo-de-Oliveira, Tony M. Ford, Mel F. Greaves, Frederik W. van Delft
Summary: The study found that adolescent and young adult T-ALL does not have specific genetic abnormalities compared to pediatric or adult T-ALL, showing a transitional genomic profile.
Article
Medicine, General & Internal
Robert Chiesa, Christos Georgiadis, Farhatullah Syed, Hong Zhan, Annie Etuk, Soragia Athina Gkazi, Roland Preece, Giorgio Ottaviano, Toni Braybrook, Jan Chu, Agnieszka Kubat, Stuart Adams, Rebecca Thomas, Kimberly Gilmour, David O'Connor, Ajay Vora, Waseem Qasim
Summary: Base editing technique has been used to inactivate genes and treat relapsed childhood T-cell leukemia with promising results.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ya-Hsuan Chang, Chih-Hsiang Yu, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Hsiu-Hao Chang, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang
Summary: Targeted sequencing of 67 genes in 64 cases of childhood T-ALL revealed a variety of genetic mutations, with high frequencies observed in NOTCH1, FAT1, FAT3, and FBXW7. Mutations in certain genes were associated with better 5-year overall survival rates for patients.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Panpan Chen, Guanfei Gao, Yuanlin Xu, Peijun Jia, Yan Li, Yating Li, Jiaming Cao, Jiangfeng Du, Shijie Zhang, Jingxin Zhang
Summary: In this study, we constructed a prognostic model for acute lymphoblastic leukemia (ALL) by identifying important genes closely related to ALL prognosis. The model can help clinicians predict the prognosis of ALL patients and adjust the treatment plan accordingly.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Jay Singh, Mercilena Benjamin, Avanish Kumar Pandey, Sarita Kumari, Mohammad Shadab Ali, Jayanth Kumar Palanichamy, Sameer Bakhshi, Amitabh Singh, Deepam Pushpam, Akash Kumar, Rachna Seth, Inder Singh, Pranay Tanwar, Amar Ranjan Singh, Gunjan Sharma, Mohit Arora, Anita Chopra
Summary: Overexpression of CRLF2 resulting from genomic rearrangement is common in Ph-like B-ALL. Detection of CRLF2 expression by flow cytometry can be used to identify Ph-like B-ALL, but its prognostic relevance in pediatric B-ALL is unclear. In this study, we evaluated CRLF2 expression in 256 pediatric B-ALL patients and found associations with CNAs and mutations. CRLF2 positivity was associated with inferior overall and event free survival, and concomitant IKZF1 CNA further increased the risk.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Mohamed Khalil, Nahla Elsharkawy, Mona Mohsen Elmawardy, Mahmoud Aly Ayoub
Summary: This study aimed to investigate the expression pattern of CD200 in acute lymphoblastic leukemia patients and its correlation with clinical and laboratory findings. The results showed a significantly higher expression of CD200 in patients compared to the control group. CD200 expression was found to be significantly correlated with total leukocytic count and hemoglobin level.
Article
Oncology
Yiwen Ling, Na Xu, Ke Zhao, Lijie Han, Qing Zhang, Zhiping Fan, Fen Huang, Zhuowen Chen, Li Xuan, Hui Liu, Jun Xu, Xiaoxia Chen, Sijian Yu, Hongsheng Zhou, Jing Sun, Qifa Liu
Summary: Emerging evidence suggests that CDKN2 deletion may be a poor prognostic predictor in adult B-ALL. Adult B-ALL patients with CDKN2 deletion may benefit from allogeneic hematopoietic cell transplant.
Article
Hematology
Qian Zhang, Mei-Juan Huang, Han-Yu Wang, Yong Wu, Yuan-Zhong Chen
Summary: This study aimed to establish a prognostic model for >= 14-year-old patients with acute lymphoblastic leukemia (ALL) and guide treatment decisions. The data of 321 ALL patients between January 2017 and June 2020 were retrospectively analyzed. A nomogram was used to construct the prognostic model, which identified independent risk factors for overall survival (OS) and progression-free survival (PFS). The model accurately stratified patients into low-risk and high-risk categories and determined the clinical strategy.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Eulalia Genesca, Mireia Morgades, Celia Gonzalez-Gil, Francisco Fuster-Tormo, Claudia Haferlach, Manja Meggendorfer, Pau Montesinos, Pere Barba, Cristina Gil, Rosa Coll, Maria-Jose Moreno, Daniel Martinez-Carballeira, Irene Garcia-Cadenas, Susana Vives, Jordi Ribera, Jose Gonzalez-Campos, Marina Diaz-Beya, Santiago Mercadal, Maria-Teresa Artola, Antonia Cladera, Mar Tormo, Arancha Bermudez, Ferran Vall-llovera, Pilar Martinez-Sanchez, Maria-Luz Amigo, Silvia Monsalvo, Andres Novo, Marta Cervera, Antonio Garcia-Guinon, Juana Ciudad, Jose Cervera, Jesus-Maria Hernandez-Rivas, Isabel Granada, Torsten Haferlach, Alberto Orfao, Francesc Sole, Josep-Maria Ribera
Summary: In adult T-cell acute lymphoblastic leukemia (T-ALL), patients with a complex karyotype characterized by >3 cytogenetic alterations have been identified as a high-risk subgroup with poor prognosis. These patients exhibit inferior response to therapy, decreased event-free survival, overall survival, and increased cumulative incidence of relapse, independent of other baseline characteristics and MRD level. Additional molecular analyses of these patients show a unique molecular profile that may help understand resistance mechanisms and assess potential novel targeted therapies for improving outcomes in adult T-ALL patients.
Review
Cell Biology
Agnieszka Kaczmarska, Justyna Derebas, Michalina Pinkosz, Maciej Niedzwiecki, Monika Lejman
Summary: The most common chromosomal rearrangement in childhood B-ALL is t(12;21)(p13;q22), resulting in the fusion of the ETV6::RUNX1 gene. Recent studies suggest that RAG-initiated deletions, as well as defects in the RAS and NRAS pathways, may influence the occurrence of translocations. The t(12;21) translocation in ETV6::RUNX1-positive B-ALL requires leukemia-causing secondary mutations.
Article
Oncology
Monika Drobna-Sledzinska, Natalia Mackowska-Maslak, Roman Jaksik, Maria Kosmalska, Bronislawa Szarzynska, Monika Lejman, Lukasz Sedek, Tomasz Szczepanski, Tom Taghon, Pieter Van Vlierberghe, Michal Witt, Malgorzata Dawidowska
Summary: This study reveals that overexpression of miR-363-3p enhances T-ALL cell growth and contributes to JAK-STAT pathway activation by inhibiting PTPRC and SOCS2. Additionally, promoter methylation may lead to downregulation of SOCS2 expression and JAK-STAT activation. These findings highlight the significance of aberrant miRNA expression and methylation in T-ALL, which are alternative mechanisms to mutations in JAK-STAT-related genes.
GENES CHROMOSOMES & CANCER
(2022)
Article
Education & Educational Research
Carles Forne, Oriol Yuguero
Summary: This study assessed the internal reliability and performance of the MBI-HSS in Spanish urgency healthcare personnel. The results showed that the MBI-HSS is a reliable and factorially valid instrument to evaluate burnout syndrome.
BMC MEDICAL EDUCATION
(2022)
Article
Biology
Sigrid Wahlen, Filip Matthijssens, Wouter Van Loocke, Sylvie Taveirne, Laura Kiekens, Eva Persyn, Els Van Ammel, Zenzi De Vos, Stijn De Munter, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Summary: The transcription factor RUNX2 plays a crucial role in the development and tissue residency of human NK cells. Manipulating its expression level can promote NK cell generation, possibly by inducing IL-2R beta expression. These findings have the potential to impact cancer therapies and other lymphocyte subpopulations research.
Article
Respiratory System
Marc Miravitlles, Fernando Gonzalez-Torralba, Cristina Represas-Represas, Xavier Pomares, Eduardo Marquez-Martin, Cruz Gonzalez, Carlos Amado, Carles Forne, Soledad Alonso, Bernardino Alcazar, Miriam Barrecheguren, Juan Maria Jurado Mirete, Elsa Naval
Summary: The survey showed a significant variation among pulmonologists in the decision to prescribe or withdraw ICS. Exacerbations, blood eosinophils, history of asthma or pneumonia were the factors considered for ICS use or withdrawal according to guidelines.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Hematology
Maaike Van Trimpont, Amanda M. Schalk, Yanti De Visser, Hien Anh Nguyen, Lindy Reunes, Katrien Vandemeulebroecke, Evelien Peeters, Ying Su, Hyun Lee, Philip L. Lorenzi, Wai-Kin Chan, Veerle Mondelaers, Barbara De Moerloose, Tim Lammens, Steven Goossens, Pieter Van Vlierberghe, Arnon Lavie
Summary: Asparagine is crucial for the growth and survival of ALL cells, which are dependent on extracellular asparagine. Current L-asparaginases, while effective, have toxic side effects due to their co-activity with L-glutaminase. A new variant, ErA-TM, with decreased L-glutaminase co-activity and maintained L-asparaginase activity, has been developed. Fusion with an albumin binding domain (ABD) significantly increases its in vivo persistence. ABD-ErA-TM shows comparable antileukemic efficacy to pegylated-asparaginase but with fewer co-glutaminase-related side effects.
Article
Immunology
Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina Doody, Martin Zenke, Tom Taghon
Summary: The interaction between thymocytes and thymic stromal cells is crucial for T cell development. This study demonstrates that intrathymic development of dendritic cells (DCs) plays a role in supporting early stages of human T cell development. The transcription factor IRF8 and transmembrane TNF are involved in this process. Selective targeting of TNFR2 has the potential to enhance the generation of T cell precursors for clinical applications.
Article
Oncology
Lien Provez, Tom Putteman, Mattias Landfors, Juliette Roels, Lindy Reunes, Sara T'Sas, Wouter Van Loocke, Beatrice Lintermans, Stien De Coninck, Morgan Thenoz, Wouter Sleeckx, Natalia Mackowska-Maslak, Tom Taghon, Marc R. Mansour, Nadine Farah, Koen Norga, Peter Vandenberghe, Rishi S. Kotecha, Steven Goossens, Sofie Degerman, Renate De Smedt, Pieter Van Vlierberghe
Summary: T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed in teenagers and young adults. Patients are usually treated with chemotherapy or hematopoietic stem cell transplantation, but relapse still occurs. Decitabine, a DNA hypomethylating agent, shows potential as a less toxic therapy. This study provides preclinical proof of the use of decitabine as a therapeutic agent in T-LBL.
Article
Oncology
Alessia Buratin, Cristina Borin, Caterina Tretti Parenzan, Anna Dal Molin, Silvia Orsi, Andrea Binatti, Katharina Simon, Maddalena Paganin, Valentina Serafin, Enrico Gaffo, Geertruij te Kronnie, Pieter Van Vlierberghe, Silvia Bresolin, Stefania Bortoluzzi
Summary: Circular RNAs (circRNAs) are recently discovered to have a significant impact on leukemogenic mechanisms, particularly in T-cell Acute Lymphoblastic Leukemia (T-ALL). This study focuses on a specific circRNA called circFBXW7, which is highly expressed in T-cells and plays a role in tumor suppression. The depletion of circFBXW7 leads to increased leukemic cell viability, activation of pro-proliferative pathways, and elevated levels of MYC and intracellular NOTCH1 proteins. These findings suggest that circFBXW7 acts as a suppressor in T-ALL and enhances the aggressive phenotype of the disease.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Elien Heylen, Paulien Verstraete, Linde Van Aerschot, Shauni L. Geeraerts, Tom Venken, Kalina Timcheva, David Nittner, Jelle Verbeeck, Jonathan Royaert, Marion Gijbels, Anne Uyttebroeck, Heidi Segers, Diether Lambrechts, Jan Cools, Kim De Keersmaecker, Kim R. Kampen
Summary: This study identifies the transcription factor NKX2-1 as a driver of serine/glycine synthesis addiction in cancer cells. NKX2-1 binds and transcriptionally upregulates serine/glycine synthesis enzyme genes, enabling cells expressing NKX2-1 to proliferate and invade in serine/glycine-depleted conditions. The findings reveal the unique metabolic rewiring of NKX2-1-driven cancers and provide possibilities for new therapeutic strategies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Bieke Decaesteker, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, Alla Berezovskaya, Geertrui Denecker, Eva D'haene, Stephane Van Haver, Wouter Van Loocke, Jo Van Dorpe, David Creytens, Nadine Van Roy, Tim Pieters, Christophe Van Neste, Matthias Fischer, Pieter Van Vlierberghe, Stephen S. Roberts, Johannes Schulte, Sara Ek, Rogier Versteeg, Jan Koster, Johan van Nes, Mark Zimmerman, Katleen De Preter, Frank Speleman
Summary: SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Christian Domingo, Rosa M. Mirapeix, Francisco-Javier Gonzalez-Barcala, Carles Forne, Felip Garcia
Summary: This study aimed to demonstrate that omalizumab is a corticosteroid-sparing therapy in patients with corticosteroid-dependent asthma, able to inhibit airway remodeling and reduce disease burden. The results showed that omalizumab significantly reduced the use of corticosteroids, improved lung function, reduced exacerbations, and facilitated bronchial epithelial repair.
Review
Biochemistry & Molecular Biology
Paulien Verstraete, Kim De Keersmaecker, Kim Rosalie Kampen
Summary: Cancer cells increase their production of serine and glycine through metabolic rewiring, specifically through upregulation of de novo serine/glycine synthesis. This review focuses on the upregulation of endogenous serine/glycine production in acute leukemia, including T-cell acute leukemia (T-ALL) and acute myeloid leukemia (AML). Genetic lesions directly impacting serine/glycine addiction in acute leukemia have been identified, along with indirect regulation of de novo serine/glycine synthesis.
Article
Infectious Diseases
Jose Aguareles, Paula Villares Fernandez, Maria Maravillas Carralon-Gonzalez, Carles Forne Izquierdo, Eva Maria Marti-Ballesteros, Virginia Pradillo Fernandez, Gabriel Sotres-Fernandez, Teresa Garcia-Delangue, Rocio Garcia de Viedma Lapetra, Maria Dolores Sanchez-Manzano, Carolina Gutierrez, Marta Garcia-Coca, Daniel Carnevali-Ruiz, Ruth Barrena-Puertas, Jose Manuel Luque-Pinilla, Raquel Lloris, Xavier Erik Luepke-Estefan, Jose Antonio Lopez-Martin, Jose Maria Jimeno, Pablo Guisado-Vasco
Summary: This study evaluates the compassionate use of plitidepsin as an antiviral treatment in immunocompromised adult patients with moderate-to-severe COVID-19. The results show that plitidepsin is well-tolerated and may have potential clinical and antiviral efficacy in these patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cell & Tissue Engineering
Samantha Zaunz, Jonathan De Smedt, Lukas Lauwereins, Lana Cleuren, Charlie Laffeber, Manmohan Bajaj, Joyce H. G. Lebbink, Jurgen A. Marteijn, Kim De Keersmaecker, Catherine Verfaillie
Summary: APEX1 plays a crucial role in adult regenerative hematopoiesis, with its nuclease and redox domains impacting proliferating HSPCs differently.
STEM CELL REVIEWS AND REPORTS
(2023)
Meeting Abstract
Hematology
Sophie Vlayen, Marino Caruso, Kim De Keersmaecker, Dirk Daelemans, Michel Delforge
EXPERIMENTAL HEMATOLOGY
(2023)