A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
出版年份 2016 全文链接
标题
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
作者
关键词
-
出版物
Scientific Reports
Volume 6, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-06-06
DOI
10.1038/srep27239
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
- (2016) Juan Carlos García-Cañaveras et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
- (2015) Juan Carlos García-Cañaveras et al. ELECTROPHORESIS
- Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment
- (2015) Davide Germano et al. TOXICOLOGY IN VITRO
- In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS
- (2014) Aitor Carretero et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- A simple transcriptomic signature able to predict drug-induced hepatic steatosis
- (2014) Marta Benet et al. ARCHIVES OF TOXICOLOGY
- Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study
- (2014) Wim F. P. M. Van den Hof et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction
- (2014) Miriam Cortes et al. JOURNAL OF HEPATOLOGY
- Integrated testing strategies for safety assessments
- (2014) Thomas Hartung ALTEX-Alternatives to Animal Experimentation
- Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression
- (2013) Meredith V. Brown et al. Obesity
- Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats
- (2013) Makoto Yamazaki et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Organotypic liver culture models: Meeting current challenges in toxicity testing
- (2012) Edward L. LeCluyse et al. CRITICAL REVIEWS IN TOXICOLOGY
- Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates
- (2012) M. Teresa Donato et al. CURRENT DRUG METABOLISM
- In vitro validation of drug-induced phospholipidosis
- (2012) Sora Park et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis
- (2012) J. Xia et al. NUCLEIC ACIDS RESEARCH
- HMDB 3.0—The Human Metabolome Database in 2013
- (2012) David S. Wishart et al. NUCLEIC ACIDS RESEARCH
- Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
- (2012) Laia Tolosa et al. TOXICOLOGICAL SCIENCES
- An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors
- (2012) Agustín Lahoz et al. TOXICOLOGY IN VITRO
- MBRole: enrichment analysis of metabolomic data
- (2011) M. Chagoyen et al. BIOINFORMATICS
- Thiol metabolomics of endothelial cells using capillary liquid chromatography mass spectrometry with isotope coded affinity tags
- (2011) Wei Yuan et al. JOURNAL OF CHROMATOGRAPHY A
- A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations
- (2011) Juan C. García-Cañaveras et al. JOURNAL OF PROTEOME RESEARCH
- Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
- (2011) Guillermo Quintás et al. Metabolomics
- MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
- (2010) Tomáš Pluskal et al. BMC BIOINFORMATICS
- In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
- (2010) M.J. Gomez-Lechon et al. CURRENT PHARMACEUTICAL DESIGN
- Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
- (2010) Brent A. Neuschwander-Tetri HEPATOLOGY
- The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine
- (2010) Federica Gibellini et al. IUBMB LIFE
- Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver
- (2010) Karima Begriche et al. JOURNAL OF HEPATOLOGY
- MassBank: a public repository for sharing mass spectral data for life sciences
- (2010) Hisayuki Horai et al. JOURNAL OF MASS SPECTROMETRY
- Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project
- (2010) María José Gómez-Lechón et al. TOXICOLOGY IN VITRO
- Cytometric analysis for drug-induced steatosis in HepG2 cells
- (2009) M. Teresa Donato et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Screening for the Drug-Phospholipid Interaction: Correlation to Phospholipidosis
- (2009) Juha-Matti Alakoskela et al. ChemMedChem
- Cell based approaches for evaluation of drug-induced liver injury
- (2009) Mhairi L. Greer et al. TOXICOLOGY
- Glutathione in liver diseases and hepatotoxicity
- (2008) Liyun Yuan et al. MOLECULAR ASPECTS OF MEDICINE
- Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury
- (2008) Jinghai J. Xu et al. TOXICOLOGICAL SCIENCES
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