LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS

(2014) Aitor Carretero et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A simple transcriptomic signature able to predict drug-induced hepatic steatosis

(2014) Marta Benet et al.   ARCHIVES OF TOXICOLOGY

Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study

(2014) Wim F. P. M. Van den Hof et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction

(2014) Miriam Cortes et al.   JOURNAL OF HEPATOLOGY

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

(2013) Helen Garside et al.   TOXICOLOGY IN VITRO

Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates

(2012) M. Teresa Donato et al.   CURRENT DRUG METABOLISM

MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis

(2012) J. Xia et al.   NUCLEIC ACIDS RESEARCH

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

(2012) Alexandra K. Leamy et al.   PROGRESS IN LIPID RESEARCH

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

(2012) Laia Tolosa et al.   TOXICOLOGICAL SCIENCES

An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors

(2012) Agustín Lahoz et al.   TOXICOLOGY IN VITRO

MBRole: enrichment analysis of metabolomic data

(2011) M. Chagoyen et al.   BIOINFORMATICS

Thiol metabolomics of endothelial cells using capillary liquid chromatography mass spectrometry with isotope coded affinity tags

(2011) Wei Yuan et al.   JOURNAL OF CHROMATOGRAPHY A

A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations

(2011) Juan C. García-Cañaveras et al.   JOURNAL OF PROTEOME RESEARCH

In vitro transcriptomic prediction of hepatotoxicity for early drug discovery

(2011) Feng Cheng et al.   JOURNAL OF THEORETICAL BIOLOGY

Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool

(2011) Guillermo Quintás et al.   Metabolomics

MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

(2010) Tomáš Pluskal et al.   BMC BIOINFORMATICS

In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs

(2010) M.J. Gomez-Lechon et al.   CURRENT PHARMACEUTICAL DESIGN

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

MassBank: a public repository for sharing mass spectral data for life sciences

(2010) Hisayuki Horai et al.   JOURNAL OF MASS SPECTROMETRY

Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

(2010) Anke Van Summeren et al.   TOXICOLOGICAL SCIENCES

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project

(2010) María José Gómez-Lechón et al.   TOXICOLOGY IN VITRO

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Cell based approaches for evaluation of drug-induced liver injury

(2009) Mhairi L. Greer et al.   TOXICOLOGY

Cell Lines: A Tool for In Vitro Drug Metabolism Studies

(2008) M. Gomez-Lechon et al.   CURRENT DRUG METABOLISM

Identification of Apoptotic Drugs: Multiparametric Evaluation in Cultured Hepatocytes

(2008) Maria Gomez-Lechon et al.   CURRENT MEDICINAL CHEMISTRY

Assessment of PLSDA cross validation

(2008) Johan A. Westerhuis et al.   Metabolomics

Glutathione in liver diseases and hepatotoxicity

(2008) Liyun Yuan et al.   MOLECULAR ASPECTS OF MEDICINE

Systems biology: Metabonomics

(2008) Jeremy K. Nicholson et al.   NATURE