A simple transcriptomic signature able to predict drug-induced hepatic steatosis

Estrogen Signalling and the Metabolic Syndrome: Targeting the Hepatic Estrogen Receptor Alpha Action

(2013) Marko Matic et al.   PLoS One

Chemotherapy-Associated Liver Injury in Patients with Colorectal Liver Metastases: A Systematic Review and Meta-analysis

(2012) Stuart M. Robinson et al.   ANNALS OF SURGICAL ONCOLOGY

An overview of transcriptional regulation in response to toxicological insult

(2012) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

A Myriad of Pathways to NASH

(2012) Soledad Larrain et al.   Clinics in Liver Disease

Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates

(2012) M. Teresa Donato et al.   CURRENT DRUG METABOLISM

Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver

(2012) Marta Moya et al.   PLoS One

Hematopoietically-Expressed Homeobox Gene Three Widely-Evaluated Polymorphisms and Risk for Diabetes: A Meta-Analysis

(2012) Xiaobo Li et al.   PLoS One

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

(2012) Laia Tolosa et al.   TOXICOLOGICAL SCIENCES

Sry-box (Sox) transcription factors in gastrointestinal physiology and disease

(2011) A. D. Gracz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The mechanistic basis for the induction of hepatic steatosis by xenobiotics

(2011) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool

(2011) Guillermo Quintás et al.   Metabolomics

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Vitamin D and the vitamin D receptor in liver pathophysiology

(2011) Silvia Zúñiga et al.   Clinics and Research in Hepatology and Gastroenterology

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

(2010) Marta Moya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies

(2010) David E. Amacher   TOXICOLOGY

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project

(2010) María José Gómez-Lechón et al.   TOXICOLOGY IN VITRO

Gene expression profiling of murine hepatic steatosis induced by tamoxifen

(2010) Min-Ho Lee et al.   TOXICOLOGY LETTERS

Cytometric analysis for drug-induced steatosis in HepG2 cells

(2009) M. Teresa Donato et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Activation of PPARα and PPARγ reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1

(2009) Bettina König et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte

(2009) Amélie Moreau et al.   HEPATOLOGY

In vitroassay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis

(2009) Hisako Fujimura et al.   JOURNAL OF APPLIED TOXICOLOGY

Histological patterns in drug-induced liver disease

(2009) R Ramachandran et al.   JOURNAL OF CLINICAL PATHOLOGY

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes

(2009) Lyudmila I. Rachek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation

(2009) Yan-Yun Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses

(2008) M. Pascual et al.   DRUG METABOLISM AND DISPOSITION

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy

(2008) Xiangbin Xing et al.   HEPATOLOGY

Gene expression profiles of murine fatty liver induced by the administration of methotrexate

(2008) Min-Ho Lee et al.   TOXICOLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

Subchronic effects of valproic acid on gene expression profiles for lipid metabolism in mouse liver

(2007) Min-Ho Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY