Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

TH9 cells are required for tissue mast cell accumulation during allergic inflammation

(2015) Sarita Sehra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells

(2015) Arianne C. Richard et al.   JOURNAL OF IMMUNOLOGY

Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients

(2015) Deimantė Hoppenot et al.   Medicina-Lithuania

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

(2015) Guillaume Voisinne et al.   Cell Reports

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients

(2015) Deimantė Hoppenot et al.   Medicina-Lithuania

IRF4 at the crossroads of effector T-cell fate decision

(2014) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Complex interactions of transcription factors in mediating cytokine biology in T cells

(2014) Peng Li et al.   IMMUNOLOGICAL REVIEWS

Counter-regulation of T cell effector function by differentially activated p38

(2014) Muhammad S. Alam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Naive and Innate Memory Phenotype CD4+ T Cells Have Different Requirements for Active Itk for Their Development

(2014) J. Hu et al.   JOURNAL OF IMMUNOLOGY

BCL6 Controls Th9 Cell Development by Repressing Il9 Transcription

(2014) R. Bassil et al.   JOURNAL OF IMMUNOLOGY

The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation

(2014) Weishan Huang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

(2014) Wei Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotype and functions of memory Tfh cells in human blood

(2014) Nathalie Schmitt et al.   TRENDS IN IMMUNOLOGY

Nitric oxide enhances Th9 cell differentiation and airway inflammation

(2014) Wanda Niedbala et al.   Nature Communications

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

(2013) Weiguo Yao et al.   IMMUNITY

Early signaling events that underlie fate decisions of naive CD4+T cells toward distinct T-helper cell subsets

(2013) Hidehiro Yamane et al.   IMMUNOLOGICAL REVIEWS

Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

(2013) Sonal Srikanth et al.   MOLECULES AND CELLS

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation

(2012) Clare S. Hardman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology

(2012) Carla P. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nuclear Factor of Activated T Cells 1 (NFAT1)-induced Permissive Chromatin Modification Facilitates Nuclear Factor-κB (NF-κB)-mediated Interleukin-9 (IL-9) Transactivation

(2012) Arijita Jash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OX40 signaling favors the induction of TH9 cells and airway inflammation

(2012) Xiang Xiao et al.   NATURE IMMUNOLOGY

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation

(2012) R. Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Association of a Single-Nucleotide Polymorphism of the IL-2 Inducible T-cell Kinase Gene with Asthma

(2011) Shin-Hwa Lee et al.   ANNALS OF HUMAN GENETICS

Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

(2011) Julio Gomez-Rodriguez et al.   FEBS Journal

STAT6-Dependent Regulation of Th9 Development

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

(2011) Christoph Wilhelm et al.   NATURE IMMUNOLOGY

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

(2010) Jennifer Kearley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

(2010) Valérie Staudt et al.   IMMUNITY

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

(2010) Ofer Feinerman et al.   Molecular Systems Biology

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

IL-9– and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity

(2008) Elizabeth E. Forbes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY