期刊
SCIENCE SIGNALING
卷 8, 期 405, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.aab0949
关键词
-
资金
- Genentech
Interleukin-2 (IL-2)-inducible T cell kinase (ITK) mediates T cell receptor (TCR) signaling primarily to stimulate the production of cytokines, such as IL-4, IL-5, and IL-13, from T helper 2 (T(H)2) cells. Compared to wild-type mice, ITK knockout mice are resistant to asthma and exhibit reduced lung inflammation and decreased amounts of T(H)2-type cytokines in the bronchoalveolar lavage fluid. We found that a small-molecule selective inhibitor of ITK blocked TCR-mediated signaling in cultured T(H)2 cells, including the tyrosine phosphorylation of phospholipase C-gamma 1 (PLC-gamma 1) and the secretion of IL-2 and T(H)2-type cytokines. Unexpectedly, inhibition of the kinase activity of ITK during or after antigen rechallenge in an ovalbumin-induced mousemodel of asthma failed to reduce airway hyperresponsiveness and inflammation. Rather, inmice, pharmacological inhibition of ITK resulted in T cell hyperplasia and the increased production of T(H)2-type cytokines. Thus, our studies predict that inhibition of the kinase activity of ITK may not be therapeutic in patients with asthma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据