The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage

(2015) Xueming Li et al.   JOURNAL OF STRUCTURAL BIOLOGY

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

(2015) Thi Hoang Duong Nguyen et al.   NATURE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Structural basis of pre-mRNA splicing

(2015) Jing Hang et al.   SCIENCE

Structure of a yeast spliceosome at 3.6-angstrom resolution

(2015) Chuangye Yan et al.   SCIENCE

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

(2015) Sunbin Liu et al.   eLife

The spliceosome: disorder and dynamics defined

(2014) Weijun Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural studies of the spliceosome: zooming into the heart of the machine

(2014) Wojciech P Galej et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution

(2014) Eric J Montemayor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endogenous U2{middle dot}U5{middle dot}U6 snRNA complexes in S. pombe are intron lariat spliceosomes

(2014) W. Chen et al.   RNA

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Beam-induced motion correction for sub-megadalton cryo-EM particles

(2014) Sjors HW Scheres   eLife

Conformation-independent structural comparison of macromolecules withProSMART

(2014) Robert A. Nicholls et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

(2013) Jermaine L. Jenkins et al.   NUCLEIC ACIDS RESEARCH

Rearrangements within human spliceosomes captured after exon ligation

(2013) J. O. Ilagan et al.   RNA

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

(2013) S. Mozaffari-Jovin et al.   SCIENCE

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

(2013) Thi Hoang Duong Nguyen et al.   STRUCTURE

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Structure and assembly of the SF3a splicing factor complex of U2 snRNP

(2012) Pei-Chun Lin et al.   EMBO JOURNAL

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome

(2012) Anna Hegele et al.   MOLECULAR CELL

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

(2011) Adelaine K. W. Leung et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Functional organization of the Sm core in the crystal structure of human U1 snRNP

(2010) Gert Weber et al.   EMBO JOURNAL

3D Cryo-EM Structure of an Active Step I Spliceosome and Localization of Its Catalytic Core

(2010) Monika M. Golas et al.   MOLECULAR CELL

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

(2010) S. Bessonov et al.   RNA

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Exon, intron and splice site locations in the spliceosomal B complex

(2009) Elmar Wolf et al.   EMBO JOURNAL

Refinement of Protein Structures into Low-Resolution Density Maps Using Rosetta

(2009) Frank DiMaio et al.   JOURNAL OF MOLECULAR BIOLOGY

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

(2009) Patrizia Fabrizio et al.   MOLECULAR CELL

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

(2009) Daniel A. Pomeranz Krummel et al.   NATURE

CHAINSAW: a program for mutating pdb files used as templates in molecular replacement

(2008) Norman Stein   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

(2008) Irina Häcker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY