The architecture of the spliceosomal U4/U6.U5 tri-snRNP

Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation

(2015) Jinzhong Lin et al.   CELL

How cryo-EM is revolutionizing structural biology

(2015) Xiao-chen Bai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evidence for a group II intron–like catalytic triplex in the spliceosome

(2014) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7

(2014) Amelie Schreieck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Beam-induced motion correction for sub-megadalton cryo-EM particles

(2014) Sjors HW Scheres   eLife

Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

(2013) Lijun Zhou et al.   NATURE

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Elongation Factor G Bound to the Ribosome in an Intermediate State of Translocation

(2013) D. S. Tourigny et al.   SCIENCE

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

(2013) S. Mozaffari-Jovin et al.   SCIENCE

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

(2013) Thi Hoang Duong Nguyen et al.   STRUCTURE

PRIME: Probabilistic Initial 3D Model Generation for Single-Particle Cryo-Electron Microscopy

(2013) Hans Elmlund et al.   STRUCTURE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning

(2012) D. Hahn et al.   GENES & DEVELOPMENT

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA

(2012) S. Mozaffari-Jovin et al.   GENES & DEVELOPMENT

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Structural bioinformatics of the human spliceosomal proteome

(2012) Iga Korneta et al.   NUCLEIC ACIDS RESEARCH

ModeRNA server: an online tool for modeling RNA 3D structures

(2011) M. Rother et al.   BIOINFORMATICS

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

(2011) Adelaine K. W. Leung et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins

(2010) Xian-Hui Wu et al.   BIOCHEMISTRY

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

(2009) Patrizia Fabrizio et al.   MOLECULAR CELL

Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome

(2009) R. J. Grainger et al.   RNA

Experimental observation of the improvement in MTF from backthinning a CMOS direct electron detector

(2009) G. McMullan et al.   ULTRAMICROSCOPY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Image processing for electron microscopy single-particle analysis using XMIPP

(2008) Sjors H W Scheres et al.   Nature Protocols

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

(2008) Irina Häcker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

(2008) Corina Maeder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of a Self-Spliced Group II Intron

(2008) N. Toor et al.   SCIENCE