U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

A Broad Range of Conformations Contribute to the Solution Ensemble of the Essential Splicing Factor U2AF65

(2012) Jermaine L. Jenkins et al.   BIOCHEMISTRY

SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing

(2011) Y. Chen et al.   GENES & DEVELOPMENT

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

(2011) Cameron D. Mackereth et al.   NATURE

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

RNA Induces Conformational Changes in the SF1/U2AF65 Splicing Factor Complex

(2010) Ankit Gupta et al.   JOURNAL OF MOLECULAR BIOLOGY

Missed threads. The impact of pre-mRNA splicing defects on clinical practice

(2009) Diana Baralle et al.   EMBO REPORTS

Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer

(2009) Joanna Fay et al.   JOURNAL OF MEDICAL VIROLOGY

RNA recognition motifs: boring? Not quite

(2008) Antoine Cléry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Solution Conformation and Thermodynamic Characteristics of RNA Binding by the Splicing Factor U2AF65

(2008) Jermaine L. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing

(2008) Duncan J. Smith et al.   MOLECULAR CELL

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Evolutionary Convergence on Highly-Conserved 3′ Intron Structures in Intron-Poor Eukaryotes and Insights into the Ancestral Eukaryotic Genome

(2008) Manuel Irimia et al.   PLoS Genetics