Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode Waveguides

(2016) Sune M. Christensen et al.   NANO LETTERS

The role of T cell receptor signaling thresholds in guiding T cell fate decisions

(2015) Julie Zikherman et al.   CURRENT OPINION IN IMMUNOLOGY

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Organization of EphA2 at the Cell-Cell Interface Modulates Trans-Endocytosis of EphrinA1

(2014) Adrienne C. Greene et al.   BIOPHYSICAL JOURNAL

Size-Based Chromatography of Signaling Clusters in a Living Cell Membrane

(2014) Niña G. Caculitan et al.   NANO LETTERS

H-Ras forms dimers on membrane surfaces via a protein-protein interface

(2014) W.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

(2014) L. Iversen et al.   SCIENCE

Phase transitions of multivalent proteins can promote clustering of membrane receptors

(2014) Sudeep Banjade et al.   eLife

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

(2013) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Nanoscale Obstacle Arrays Frustrate Transport of EphA2–Ephrin-A1 Clusters in Cancer Cell Lines

(2013) Theobald Lohmüller et al.   NANO LETTERS

The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo

(2013) R. L. Kortum et al.   Science Signaling

Eph Receptor Signaling and Ephrins

(2013) E. M. Lisabeth et al.   Cold Spring Harbor Perspectives in Biology

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane

(2012) D. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concepts and consequences of Eph receptor clustering

(2012) Peter W. Janes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

(2010) Jodi Gureasko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Aggregation of Membrane Proteins by Cytosolic Cross-Linkers: Theory and Simulation of the LAT-Grb2-SOS1 System

(2009) Ambarish Nag et al.   BIOPHYSICAL JOURNAL

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Bayesian Detection of Intensity Changes in Single Molecule and Molecular Dynamics Trajectories

(2009) Daniel L. Ensign et al.   JOURNAL OF PHYSICAL CHEMISTRY B

On the Mechanism of Trolox as Antiblinking and Antibleaching Reagent

(2009) Thorben Cordes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Kinetic Control of Histidine-Tagged Protein Surface Density on Supported Lipid Bilayers

(2008) Jeffrey A. Nye et al.   LANGMUIR

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Membrane-dependent signal integration by the Ras activator Son of sevenless

(2008) Jodi Gureasko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY