The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production

(2015) Mahmood Yousif Bilal et al.   Frontiers in Immunology

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers

(2014) Noga Kozer et al.   BIOCHEMISTRY

Membrane microdomains in immunoreceptor signaling

(2014) Vaclav Horejsi et al.   FEBS LETTERS

Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses

(2014) Helena Soares et al.   IMMUNOLOGICAL REVIEWS

STED microscopy: increased resolution for medical research?

(2014) H. Blom et al.   JOURNAL OF INTERNAL MEDICINE

Localization microscopy: mapping cellular dynamics with single molecules

(2014) A.J. NELSON et al.   JOURNAL OF MICROSCOPY

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

(2013) N. P. Coussens et al.   MOLECULAR AND CELLULAR BIOLOGY

The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo

(2013) R. L. Kortum et al.   Science Signaling

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells

(2013) Robert L. Kortum et al.   TRENDS IN IMMUNOLOGY

Cooperativity in Cellular Biochemical Processes: Noise-Enhanced Sensitivity, Fluctuating Enzyme, Bistability with Nonlinear Feedback, and Other Mechanisms for Sigmoidal Responses

(2012) Hong Qian   Annual Review of Biophysics

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Ligand binding induces a conformational change in epidermal growth factor receptor dimers

(2012) Francesca Walker et al.   GROWTH FACTORS

Deconstructing Ras Signaling in the Thymus

(2012) R. L. Kortum et al.   MOLECULAR AND CELLULAR BIOLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Modeling and Simulation of Aggregation of Membrane Protein LAT with Molecular Variability in the Number of Binding Sites for Cytosolic Grb2-SOS1-Grb2

(2012) Ambarish Nag et al.   PLoS One

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

(2011) Rémi Lasserre et al.   JOURNAL OF CELL BIOLOGY

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

(2011) L. Balagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Sos1 deletion reveals its critical role in early T-cell development

(2011) R. L. Kortum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vav1-Mediated Scaffolding Interactions Stabilize SLP-76 Microclusters and Contribute to Antigen-Dependent T Cell Responses

(2011) N. R. Sylvain et al.   Science Signaling

The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells

(2010) Shudan Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decision checkpoints in the thymus

(2010) Andrea C Carpenter et al.   NATURE IMMUNOLOGY

Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection

(2010) I. K. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

Aggregation of Membrane Proteins by Cytosolic Cross-Linkers: Theory and Simulation of the LAT-Grb2-SOS1 System

(2009) Ambarish Nag et al.   BIOPHYSICAL JOURNAL

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

(2009) Michael Mingueneau et al.   IMMUNITY

Palmitoylation-Dependent Plasma Membrane Transport but Lipid Raft-Independent Signaling by Linker for Activation of T Cells

(2009) M. Hundt et al.   JOURNAL OF IMMUNOLOGY

The Essential Role of LAT in Thymocyte Development during Transition from the Double-Positive to Single-Positive Stage

(2009) S. Shen et al.   JOURNAL OF IMMUNOLOGY

Phosphotyrosine-dependentin vitroreconstitution of recombinant LAT-nucleated multiprotein signalling complexes on liposomes

(2009) Dhaval Sangani et al.   MOLECULAR MEMBRANE BIOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

(2008) Anne K Kenworthy   EMBO REPORTS

Predominance of activated EGFR higher-order oligomers on the cell surface

(2008) Andrew H. A. Clayton et al.   GROWTH FACTORS

Signal initiation in T-cell receptor microclusters

(2008) Maria-Cristina Seminario et al.   IMMUNOLOGICAL REVIEWS

Cooperativity and biological complexity

(2008) Adrian Whitty   Nature Chemical Biology