Article
Biochemistry & Molecular Biology
Hongling Huang, Peipei Zhou, Jun Wei, Lingyun Long, Hao Shi, Yogesh Dhungana, Nicole M. Chapman, Guotong Fu, Jordy Saravia, Jana L. Raynor, Shaofeng Liu, Gustavo Palacios, Yong-Dong Wang, Chenxi Qian, Jiyang Yu, Hongbo Chi
Summary: This study reveals that amino acid transporters play a role in dampening T-MEM differentiation, while Pofut1 is a key regulator for terminal effector differentiation of T-EFF cells. These findings highlight the importance of nutrient uptake and signaling in determining T cell fate.
Article
Multidisciplinary Sciences
Michael P. Gallagher, James M. Conley, Pranitha Vangala, Manuel Garber, Andrea Reboldi, Leslie J. Berg
Summary: The strength of peptide:MHC interactions with the T cell receptor (TCR) is correlated with key aspects of T cell activation, including cell division time and effector cell response scale. ITK plays a crucial role in orchestrating the optimal activation of separate TCR downstream pathways, particularly aiding NF-κB activation. Variations in TCR signal strength can produce patterns of graded gene expression in activated T cells, highlighting the complex interplay between signaling cascades in T cell activation programming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Ines Sturmlechner, Abhinav Jain, Yunmei Mu, Cornelia M. Weyand, Jorg J. Goronzy
Summary: The defense against infectious diseases relies on the generation and maintenance of protective T cell memory. However, T cell differentiation in older adults tends to generate effector cells at the expense of memory and Tfh cells. This leads to poor vaccine responses, increased inflammatory state, and shorter life spans.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Immunology
Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch
Summary: TCR signaling plays a crucial role in the development of T cells and the formation of self-reactive T cells, particularly in type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Kihak Gwon, Hye Jin Hong, Alan M. Gonzalez-Suarez, Michael Q. Slama, Daheui Choi, Jinkee Hong, Harihara Baskaran, Gulnaz Stybayeva, Quinn P. Peterson, Alexander Revzin
Summary: In this study, bioactive microcapsules were developed to address the challenges of high cost and difficulty in scaling-up of human pluripotent stem cells (hPSC) differentiation protocols. The results showed that these microcapsules were able to induce and maintain pluripotency of hPSCs, as well as improve the differentiation outcomes.
BIOACTIVE MATERIALS
(2022)
Review
Cell Biology
Gat Rauner, Charlotte Kuperwasser
Summary: Cell fate decisions in the mammary gland are tightly controlled by the microenvironment, specifically by the extracellular matrix, immune microenvironment, and hormones. Pathological changes in the microenvironment can alter cell fates, leading to malignancy. This review highlights how these elements converge to promote DNA damage and affect mammary cell fate.
DEVELOPMENTAL CELL
(2021)
Article
Engineering, Environmental
Shaochen Pang, Yue Gao, Yanwu Wang, Xinglei Yao, Mengxi Cao, Yong Liang, Maoyong Song, Guibin Jiang
Summary: TBBPA exposure disrupts early embryonic development, perturbing cell fate decisions along the DV axis and leading to impaired organogenesis. This highlights the potential ecological and health risks associated with TBBPA.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Cell Biology
Carlos Garcia-Padilla, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Angel Duenas, Maria del Mar Munoz-Gallardo, Isabel S. Garcia-Valencia, Lledo Palencia-Vincent, Amelia Aranega, Diego Franco
Summary: Bmp and Fgf signaling are involved in embryonic development, and their modulation of microRNAs plays a crucial role in regulating cell fate during cardiomyogenesis and PE/ST development. However, the role of Bmp and Fgf signaling in mouse PE/ST development is different from that in chicken, and their impact on cardiomyogenesis and fibrogenesis is limited. Species-specific differences in regulating PE/ST cardiomyogenic lineage commitment are supported by the data.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Jeffrey L. Carson, Simon J. Stanworth, Jane A. Dennis, Marialena Trivella, Nareg Roubinian, Dean A. Fergusson, Darrell Triulzi, Carolyn Doree, Paul C. Hebert
Summary: Restrictive transfusion strategies reduced the risk of receiving at least one RBC transfusion by 41% across a broad range of clinical contexts, with no impact on 30-day mortality or other outcomes. The study suggests that transfusions with allogeneic RBCs can be avoided in most patients with hemoglobin thresholds between 7.0 g/dL and 8.0 g/dL, but more research is needed for specific clinical contexts.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Tianzhuo Zhang, Qianwen Shi, Huining Gu, Biaoyi Yu, Sha Yin, Qing Ge, Xiaoning Mo, Xiaofeng Liu, Jing Huang
Summary: CCDC134 is a cytokine-like molecule that serves as a positive regulator of TCR-proximal signaling by interacting with CD3e and modulating its ubiquitination and degradation. T cell-specific deletion of Ccdc134 results in decreased mature CD4(+) and CD8(+) T cells, impaired T cell homeostasis, and attenuated response to TCR stimulation in vitro and in vivo. These findings highlight the importance of CCDC134 in T cell development and function, and its role in T cell-mediated inflammatory and antitumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Sydney Treichel, Marie-Dominique Filippi
Summary: Hematopoietic stem cells have the ability to self-renew or differentiate into various blood cell lineages. The cell fate decisions of self-renewal or differentiation must be tightly controlled to prevent diseases like bone marrow failure or leukemia. Studies have shown that the cell cycle length plays a crucial role in hematopoietic stem cell fate. Cell cycle kinetics, divisional history, asymmetric cell divisions, metabolic and organelle activity all have an impact on hematopoietic stem cell fate decisions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Joshua R. Wheeler, Oscar N. Whitney, Thomas O. Vogler, Eric D. Nguyen, Bradley Pawlikowski, Evan Lester, Alicia Cutler, Tiffany Elston, Nicole Dalla Betta, Kevin R. Parker, Kathryn E. Yost, Hannes Vogel, Thomas A. Rando, Howard Y. Chang, Aaron M. Johnson, Roy Parker, Bradley B. Olwin
Summary: This research reveals that the timing of RNA-binding protein (RBPs) expression can specify the fate transitions of muscle stem cells, playing a crucial role in skeletal muscle regeneration.
Article
Cell Biology
Shiyang Chen, Yajuan Zheng, Xiaojuan Ran, Hui Du, Hua Feng, Lei Yang, Yating Wen, Changdong Lin, Shihui Wang, Mengwen Huang, Zhanjun Yan, Dianqing Wu, Hongyan Wang, Gaoxiang Ge, An Zeng, Yi Arial Zeng, Jianfeng Chen
Summary: T cell contact with intestinal stem cells and transient amplifying cells plays a crucial role in regulating ISC differentiation by influencing the Wnt and Notch signaling pathways through cell-cell signaling. This interaction is essential in maintaining intestinal homeostasis and highlighting the importance of immune cells in intestinal function.
Review
Immunology
Caitlyn Guldenpfennig, Emma Teixeiro, Mark Daniels
Summary: NF-κB signaling is crucial for an effective immune response. Understanding the regulation and outcome of NF-κB signaling is of great importance in immunology research. Here, we discuss the role of NF-κB in regulating cell fate decisions during B cell development, activation, and long-term humoral immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Kulbhushan Sharma, Nagham T. Asp, Sean P. Harrison, Richard Siller, Saphira F. Baumgarten, Swapnil Gupta, Maria E. Chollet, Elisabeth Andersen, Gareth J. Sullivan, Anne Simonsen
Summary: This study investigates the role of autophagy in early events of lineage commitment using human embryonic and induced pluripotent stem cells. They found that modulation of autophagy affects SOX2 levels and lineage commitment, with autophagy promoting mesendoderm formation and inhibiting neuroectoderm formation. The results suggest that autophagy-mediated SOX2 turnover is a key factor in determining lineage commitment.
Article
Immunology
James Mueller, Mehrdad Matloubian, Julie Zikherman
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Robyn E. Mills, Viola C. Lam, Allison Tan, Nicole Cresalia, Nir Oksenberg, Julie Zikherman, Mark Anderson, Arthur Weiss, Michelle L. Hermiston
JOURNAL OF IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Sarah Coughlin, Mark Noviski, James L. Mueller, Ammarina Chuwonpad, William C. Raschke, Arthur Weiss, Julie Zikherman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Immunology
Byron B. Au-Yeung, Geoffrey Alexander Smith, James L. Mueller, Cheryl S. Heyn, Rebecca Garrett Jaszczak, Arthur Weiss, Julie Zikherman
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Adam H. Courtney, Jeanine F. Amacher, Theresa A. Kadlecek, Marianne N. Mollenauer, Byron B. Au-Yeung, John Kuriyan, Arthur Weiss
Article
Biochemistry & Molecular Biology
Andre Limnander, Julie Zikherman, Tannia Lau, Michael Leitges, Arthur Weiss, Jeroen P. Roose
MOLECULAR AND CELLULAR BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Christophe Come, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimentel, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck
Article
Biology
Hyewon Phee, Byron B. Au-Yeung, Olga Pryshchep, Kyle Leonard O'Hagan, Stephanie Grace Fairbairn, Maria Radu, Rachelle Kosoff, Marianne Mollenauer, Debra Cheng, Jonathan Chernoff, Arthur Weiss
Article
Multidisciplinary Sciences
Wendy M. Zinzow-Kramer, Arthur Weiss, Byron B. Au-Yeung
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Immunology
Corey Tan, Ryosuke Hiwa, James L. Mueller, Vivasvan Vykunta, Kenta Hibiya, Mark Noviski, John Huizar, Jeremy F. Brooks, Jose Garcia, Cheryl Heyn, Zhongmei Li, Alexander Marson, Julie Zikherman
Review
Immunology
Joel Eggert, Byron Au-Yeung
Summary: Recent research shows that strong tonic TCR signal can influence T cell metabolism, effector differentiation, and signal transduction. Adaptation to tonic signaling has lasting effects on T cell activation and differentiation.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Review
Immunology
Ryosuke Hiwa, Jeremy F. Brooks, James L. Mueller, Hailyn Nielsen, Julie Zikherman
Summary: This review discusses the important role of the NR4A family of nuclear hormone receptors in immune tolerance and explores the mechanisms by which they regulate self-tolerance and immune homeostasis.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Wen Lu, Ynes A. Helou, Krishna Shrinivas, Jen Liou, Byron B. Au-Yeung, Arthur Weiss
Summary: Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C-gamma (PLC gamma 1) is critical for T cell signaling. PI transfer protein (PITP) Nir3 (Pitpnm2) promotes PIP2 replenishment and is important for T cell development. Deficiency of Nir3 slows down PIP2 replenishment, weakens TCR signaling, and impairs thymocyte development and T cell fitness.
