The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo

Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate

(2013) Greg M. Findlay et al.   CELL

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Cutting Edge: Cell Surface Linker for Activation of T Cells Is Recruited to Microclusters and Is Active in Signaling

(2013) L. Balagopalan et al.   JOURNAL OF IMMUNOLOGY

Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner

(2013) Caleb B. McDonald et al.   JOURNAL OF MOLECULAR RECOGNITION

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells

(2013) Robert L. Kortum et al.   TRENDS IN IMMUNOLOGY

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

(2012) Chi-Chuan Lin et al.   CELL

The Role of Ras Guanine Nucleotide Releasing Protein 4 in FcϵRI-mediated Signaling, Mast Cell Function, and T Cell Development

(2012) Minghua Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deconstructing Ras Signaling in the Thymus

(2012) R. L. Kortum et al.   MOLECULAR AND CELLULAR BIOLOGY

Modeling and Simulation of Aggregation of Membrane Protein LAT with Molecular Variability in the Number of Binding Sites for Cytosolic Grb2-SOS1-Grb2

(2012) Ambarish Nag et al.   PLoS One

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Targeted Sos1 deletion reveals its critical role in early T-cell development

(2011) R. L. Kortum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances Internalization

(2010) Erik G. Hofman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

(2010) Siew Siew Pang et al.   NATURE

Decision checkpoints in the thymus

(2010) Andrea C Carpenter et al.   NATURE IMMUNOLOGY

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL