标题
Cellular functions of TMEM16/anoctamin
作者
关键词
Anoctamin, TMEM16, Ca<sup>2+</sup>-activated Cl<sup>−</sup> channel, Scramblase, Cl<sup>−</sup> secretion, Nociception, Tumorigenesis, Proliferation
出版物
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 468, Issue 3, Pages 443-453
出版商
Springer Nature
发表日期
2016-01-25
DOI
10.1007/s00424-016-1790-0
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion
- (2015) Mohamad M. Adada et al. FASEB JOURNAL
- Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6)
- (2015) Amelia Mazzone et al. FASEB JOURNAL
- Ano1/TMEM16A Overexpression Is Associated with Good Prognosis in PR-Positive or HER2-Negative Breast Cancer Patients following Tamoxifen Treatment
- (2015) Huizhe Wu et al. PLoS One
- A fluid secretion pathway unmasked by acinar-specificTmem16Agene ablation in the adult mouse salivary gland
- (2015) Marcelo A. Catalán et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels
- (2015) Christian J. Peters et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons
- (2015) Yasunori Takayama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia
- (2015) Joo Young Cha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer
- (2015) Anke Bill et al. Oncotarget
- TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation
- (2015) Ronak Dixit et al. Scientific Reports
- Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin
- (2015) Emanuela Caci et al. PLoS One
- Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer
- (2015) Linghan Jia et al. PLoS One
- Anoctamin 1 in secretory epithelia
- (2014) Yongwoo Jang et al. CELL CALCIUM
- A novelTMEM16Asplice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells
- (2014) Torsten Ertongur-Fauth et al. EXPERIMENTAL DERMATOLOGY
- Small Molecule-facilitated Degradation of ANO1 Protein
- (2014) Anke Bill et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function
- (2014) Diana Faria et al. KIDNEY INTERNATIONAL
- Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity
- (2014) Byeongjun Lee et al. Molecular Pain
- X-ray structure of a calcium-activated TMEM16 lipid scramblase
- (2014) Janine D. Brunner et al. NATURE
- ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)
- (2014) D. R. P. Sauter et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine
- (2014) Rainer Schreiber et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Inhibition of TMEM16A Expression Suppresses Growth and Invasion in Human Colorectal Cancer Cells
- (2014) Yujie Sui et al. PLoS One
- Mapping of long-rangeINSpromoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion
- (2014) Zhixiong Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity
- (2014) Jason Tien et al. eLife
- Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
- (2013) Z.-Z. Shi et al. CLINICAL CANCER RESEARCH
- Anoctamin 1 Mediates Thermal Pain as a Heat Sensor
- (2013) Hawon Cho et al. Current Neuropharmacology
- Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation
- (2013) K. Alexa Orr Gandy et al. FASEB JOURNAL
- Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members
- (2013) Jun Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TMEM16E (GDD1) Exhibits Protein Instability and Distinct Characteristics in Chloride Channel/Pore Forming Ability
- (2013) Ta To Tran et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells
- (2013) Bjoern Buchholz et al. KIDNEY INTERNATIONAL
- TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing
- (2013) Fen Huang et al. NATURE NEUROSCIENCE
- Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
- (2013) Adrian Britschgi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human scc-25 cells
- (2013) Y. Li et al. Medicina Oral Patologia Oral y Cirugia Bucal
- Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension
- (2012) Abigail S. Forrest et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Mechanosensitive Cl− secretion in biliary epithelium mediated through TMEM16A
- (2012) Amal K. Dutta et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01
- (2012) Alison J Davis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibition of Ca2+-activated Cl− channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma
- (2012) Wen Liu et al. CANCER LETTERS
- TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression
- (2012) U. Duvvuri et al. CANCER RESEARCH
- TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation
- (2012) Huanghe Yang et al. CELL
- TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries
- (2012) Simon Bulley et al. CIRCULATION RESEARCH
- Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology
- (2012) Kuai Yu et al. CIRCULATION RESEARCH
- Discovered on gastrointestinal stromal tumour 1 (DOG1): a useful immunohistochemical marker for diagnosing chondroblastoma
- (2012) Hana Akpalo et al. HISTOPATHOLOGY
- DOG1 immunoreactivity in uterine leiomyosarcomas
- (2012) Shatrughan P Sah et al. JOURNAL OF CLINICAL PATHOLOGY
- Epidermal growth factor chronically upregulates Ca2+-dependent Cl−conductance and TMEM16A expression in intestinal epithelial cells
- (2012) Magdalena S. Mroz et al. JOURNAL OF PHYSIOLOGY-LONDON
- Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity
- (2012) Hui Sun et al. JOURNAL OF PHYSIOLOGY-LONDON
- Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
- (2012) Paolo Scudieri et al. JOURNAL OF PHYSIOLOGY-LONDON
- DOG1: a novel marker of salivary acinar and intercalated duct differentiation
- (2012) Jacinthe Chênevert et al. MODERN PATHOLOGY
- The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
- (2012) Hawon Cho et al. NATURE NEUROSCIENCE
- Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons
- (2012) Wendy C. Huang et al. NEURON
- Enhanced Expression of ANO1 in Head and Neck Squamous Cell Carcinoma Causes Cell Migration and Correlates with Poor Prognosis
- (2012) Christian Ruiz et al. PLoS One
- Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network
- (2012) P. Perez-Cornejo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
- (2012) F. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DOG1 Antibody Is a Highly Sensitive and Specific Marker for Gastrointestinal Stromal Tumors in Cytology Cell Blocks
- (2011) Dick G. Hwang et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins
- (2011) Charity Duran et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- TMEM16A channels generate Ca2+-activated Cl− currents in cerebral artery smooth muscle cells
- (2011) Candice Thomas-Gatewood et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Ca2+-activated Cl− currents are dispensable for olfaction
- (2011) Gwendolyn M Billig et al. NATURE NEUROSCIENCE
- Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption
- (2011) Jiraporn Ousingsawat et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Anoctamins
- (2011) Karl Kunzelmann et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop
- (2011) Q. Xiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Utility of Discovered on Gastrointestinal Stromal Tumor 1 (DOG1) Antibody in Surgical Pathology—the GIST of It
- (2010) Cheng-Han Lee et al. ADVANCES IN ANATOMIC PATHOLOGY
- Recessive Mutations in the Putative Calcium-Activated Chloride Channel Anoctamin 5 Cause Proximal LGMD2L and Distal MMD3 Muscular Dystrophies
- (2010) Véronique Bolduc et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Expression profile and protein translation of TMEM16A in murine smooth muscle
- (2010) Alison J. Davis et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
- (2010) C Ayoub et al. BRITISH JOURNAL OF CANCER
- Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers
- (2010) Manoj K. Kashyap et al. CANCER BIOLOGY & THERAPY
- Tmem16b is Specifically Expressed in the Cilia of Olfactory Sensory Neurons
- (2010) Sebastian Rasche et al. CHEMICAL SENSES
- DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours
- (2010) Marco Novelli et al. HISTOPATHOLOGY
- Tmem16AEncodes the Ca2+-activated Cl−Channel in Mouse Submandibular Salivary Gland Acinar Cells
- (2010) Victor G. Romanenko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells
- (2010) Wan Namkung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– channels
- (2010) Boyi Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- TMEM16A/Anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells
- (2010) Boris Manoury et al. JOURNAL OF PHYSIOLOGY-LONDON
- Calcium-dependent phospholipid scrambling by TMEM16F
- (2010) Jun Suzuki et al. NATURE
- A Novel Monoclonal Antibody Against DOG1 is a Sensitive and Specific Marker for Gastrointestinal Stromal Tumors
- (2009) Inigo Espinosa et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- DOG1 Antibody in the Differential Diagnosis of Gastrointestinal Stromal Tumors
- (2009) Markku Miettinen et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport
- (2009) Jiraporn Ousingsawat et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles
- (2009) Sung Jin Hwang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Prognostic Significance of Epidermal Growth Factor Receptor Phosphorylation and Mutation in Head and Neck Squamous Cell Carcinoma
- (2009) T. Hama et al. ONCOLOGIST
- TMEM16B induces chloride currents activated by calcium in mammalian cells
- (2009) Simone Pifferi et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification
- (2009) Aaron B. Stephan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Studies on expression and function of the TMEM16A calcium-activated chloride channel
- (2009) Fen Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit
- (2008) Björn Christian Schroeder et al. CELL
- TMEM16A confers receptor-activated calcium-dependent chloride conductance
- (2008) Young Duk Yang et al. NATURE
- TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
- (2008) A. Caputo et al. SCIENCE
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