Article
Immunology
Mihaly Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd
Summary: This study demonstrates that colon cancer is associated with latent sensory neuron dysfunction and implicates cytokine/chemokine signaling in this process. These findings may have implications for determining risk factors and treatment responsiveness related to neuropathy in colorectal cancer.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Behavioral Sciences
Tianrui Zhang, Mingqian Zhang, Shuang Cui, Wulin Liang, Zhanhong Jia, Fanfan Guo, Wenjing Ou, Yonghong Wu, Shuofeng Zhang
Summary: This review investigates the neuropathic pain caused by nervous system injury or dysfunction and highlights the crucial role played by the crosstalk among microglia, astrocytes, and neurons in maintaining this pain state. The activation of the microglia P2X4 receptor seems to be the key target in this process.
BRAIN AND BEHAVIOR
(2023)
Article
Plant Sciences
Yonglan Ruan, Xiang Jin, Haiwang Ji, Chan Zhu, Yan Yang, Yuan Zhou, Guang Yu, Changming Wang, Zongxiang Tang
Summary: In this study, it was found that Notopterygium incisum alleviates cold allodynia in chronic constriction injury (CCI) and cisplatin induced neuropathic pain mouse models. This effect is achieved through directly modulating Transient Receptor Potential A1 (TRPA1) and reducing the sensitivity to cold pain. The findings highlight Notopterygium incisum as a promising candidate for treating neuropathic pain.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Mohammad Mehdi Haghighat Lari, Hamid Reza Banafshe, Elahe Seyed Hosseini, Hamed Haddad Kashani
Summary: In this study, the chronic administration of risperidone was found to be effective in reducing heat hyperalgesia and allodynia in rats with neuropathic pain induced by the CCI model. However, acute administration of risperidone did not show any significant changes in behavioral tests. Gene expression analysis indicated an increase in IL-4 and IL-10 gene expression in the risperidone group compared to the sham group.
INFLAMMOPHARMACOLOGY
(2023)
Article
Neurosciences
Michiel van der Vlist, Ramin Raoof, Hanneke L. D. M. Willemen, Judith Prado, Sabine Versteeg, Christian Martin Gil, Martijn Vos, Roeland E. Lokhorst, R. Jeroen Pasterkamp, Toshiyuki Kojima, Hajime Karasuyama, William Khoury-Hanold, Linde Meyaard, Niels Eijkelkamp
Summary: The resolution of inflammatory pain is actively controlled by macrophages through the transfer of mitochondria to sensory neurons. This process requires the expression of CD200R on macrophages and the non-canonical CD200R ligand iSec1 on sensory neurons.
Article
Neurosciences
Yan-Fang Kong, Wei-Lin Sha, Xiao-Bo Wu, Lin-Xia Zhao, Ling-Jie Ma, Yong-Jing Gao
Summary: Chemokines and their receptors play a role in chronic pain pathogenesis, with CXCR3 and CXCL10 specifically influencing neuronal excitability in the dorsal root ganglion. Activation of CXCR3 by CXCL10 leads to p38 and ERK activation in DRG neurons, enhancing neuronal excitability and contributing to neuropathic pain maintenance.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Kaimei Lu, Bin Fang, Yuqi Liu, Fangxia Xu, Chengcheng Zhou, Lijuan Wang, Lianhua Chen, Lina Huang
Summary: This study investigated the effects of neuropathic pain (NP) on serum and dorsal root ganglion (DRG) metabolites using a non-targeted metabolomics approach. The results revealed complex disturbances in phospholipid, amino acid, and acylcarnitine metabolism in the DRG of NP mice. Phospholipid metabolic disorders and impaired glucose metabolism were also observed in the serum, and there were correlations between the metabolic differences in the DRG and serum.
Article
Cell Biology
Huixing Wang, Xiaodong Huo, Chenyang Han, Jiang Ning, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Quanbo Li, Yonghao Yu, Kemei Shi
Summary: The study in rats indicated that ferroptosis is involved in the development of neuropathic pain by blocking neuron and astrocyte activation in the spinal dorsal horn.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ling Chen, Qiguo Hu, Huaicun Liu, Yan Zhao, Sun-On Chan, Jun Wang
Summary: The study revealed that microtubules play a crucial role in inflammatory pain, and Nogo-A regulated microtubule assembly is essential for the development of thermal hyperalgesia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiang Xu, Xijie Zhou, Jian Du, Xiao Liu, Liming Qing, Blake N. Johnson, Xiaofeng Jia
Summary: Autotomy, self-mutilation of a denervated limb, is common in animals after peripheral nerve injury (PNI) and is a reliable proxy for neuropathic pain in humans. Understanding the occurrence and treatment of autotomy remains challenging. The study found that nude rats engaged in autotomy with less frequency and less severe symptoms compared to Wistar rats, possibly due to differences in macrophage activation and fiber sensitization in the dorsal root ganglion (DRG) between the two groups. Increased macrophage accumulation and activation in the DRG of Wistar rats may account for the increased frequency and severity of autotomy in this group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Myrna Deciga-Campos, Rodrigo Villafan-Gutierrez, Josue Vidal Espinosa-Juarez, Osmar Antonio Jaramillo-Morales, Francisco Javier Lopez-Munoz
Summary: The study found that specific combinations of gabapentin and haloperidol can synergistically reduce nerve injury-induced allodynia and hyperalgesia, demonstrating an antiallodynic and antihyperalgesic effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Anesthesiology
Allison M. Barry, Na Zhao, Xun Yang, David L. Bennett, Georgios Baskozos
Summary: This study performed RNA-seq analysis on subtypes of dorsal root ganglia (DRG) neurons to investigate their transcriptional profiles in acute and chronic pain states, while considering sex differences. The results revealed both stereotyped and unique subtype signatures in injured states and previously unknown sex differences in naive states, contributing to differences in injured neurons.
Article
Cell Biology
Yifan Deng, Dongdong Yuan, Zhizhao Deng, Jianfen Liang, Zhenye Zhang, Ziqing Hei, Xiang Li
Summary: This study investigated the therapeutic effect and related mechanism of bone marrow-derived mesenchymal stem cells (BMSCs) on inflammatory pain. The results showed that BMSCs alleviated hypersensitivity and reduced spinal levels of pro-inflammatory factors in rats treated with CFA. This effect was achieved by inhibiting the expression of P2X3 and suppressing excessive production of inflammatory mediators.
CELL PROLIFERATION
(2023)
Article
Neurosciences
Diana J. Goode, Derek C. Molliver
Summary: This study identifies a mechanism for regulating mitochondrial function by Epac2 in DRG sensory neurons, contributing to acute inflammatory hyperalgesia in male mice. Systemic administration of the cyclooxygenase 2 inhibitor celecoxib can suppress Pdha1 phosphorylation in male DRG, thereby alleviating PGE2-induced heat hyperalgesia.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Dermatology
Sara Moradi Tuchayi, Ying Wang, Alla Khodorova, Isaac J. Pence, Conor L. Evans, R. Rox Anderson, Ethan A. Lerner, Clifford J. Woolf, Lilit Garibyan
Summary: We developed a neural selective and injectable cryoneurolysis method using ice slurry, which effectively reduces cutaneous pain caused by skin disease. This method shows comparable effects on nerve structure and function compared to an FDA-approved cryoneurolysis device. The decrease in mechanical pain from slurry injection, although less profound than that of the FDA-approved device, lasts longer without inducing dysesthesia.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)