Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

Different Epidermal Growth Factor (EGF) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation

(2014) Jennifer L. Macdonald-Obermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

(2014) Emilie Degagné et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration

(2014) Eric Bradley et al.   PLoS One

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

(2014) Jing Chen et al.   PLoS Genetics

Molecular and physiological functions of sphingosine 1-phosphate transporters

(2013) Tsuyoshi Nishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics

(2013) Mohamad Adada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation

(2013) K. Alexa Orr Gandy et al.   FASEB JOURNAL

Roles, regulation and inhibitors of sphingosine kinase 2

(2013) Heidi A. Neubauer et al.   FEBS Journal

The structure and function of the S1P1 receptor

(2013) Catherine O'Sullivan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development

(2013) Y. Hisano et al.   Biology Open

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

(2012) K. Alexa Orr Gandy et al.   BIOCHEMICAL JOURNAL

Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression

(2012) De-Fu Sun et al.   CANCER LETTERS

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Protein Phosphatase 1α Mediates Ceramide-induced ERM Protein Dephosphorylation

(2012) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases

(2012) Peng Gao et al.   PLoS One

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

(2011) Vladimir Beljanski et al.   CANCER BIOLOGY & THERAPY

The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

(2011) Deanna Siow et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined anticancer effects of sphingosine kinase inhibitors and sorafenib

(2010) Vladimir Beljanski et al.   INVESTIGATIONAL NEW DRUGS

Differential Effects of Ceramide and Sphingosine 1-Phosphate on ERM Phosphorylation

(2010) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease

(2010) Lynn W. Maines et al.   INFLAMMOPHARMACOLOGY

A lipid binding domain in sphingosine kinase 2

(2009) Anthony S. Don et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: Possible role in regulating cell division

(2009) Laura Gillies et al.   CELLULAR SIGNALLING

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

(2009) Andreas Weigert et al.   INTERNATIONAL JOURNAL OF CANCER

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis

(2009) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies

(2009) Nicole O'Brien et al.   JOURNAL OF LIPID RESEARCH

Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration

(2009) K Endo et al.   ONCOGENE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Lamellipodia and filopodia in metastasis and invasion

(2008) Laura M. Machesky   FEBS LETTERS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE