Review
Biochemistry & Molecular Biology
David C. Dorman
Summary: This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. The review highlights contributions made by Professor Michael Aschner's laboratory in this field of study, which have significantly advanced our understanding of cellular responses to manganese exposure. His research has identified molecular targets of manganese toxicity and explored the role of astrocytes in neurotoxicity, as well as discovered new facets of manganese-induced neurotoxicity using C. elegans.
Article
Environmental Sciences
Haibo Chen, Xin Hua, Hui Li, Chen Wang, Yao Dang, Ping Ding, Yunjiang Yu
Summary: This study found that maternal exposure to PS-MPs can result in the transgenerational neurotoxicity in C. elegans, with oxidative stress playing a key role in this process. Furthermore, the upregulation of oxidative stress-related genes across generations may be involved in regulating neurotoxicity in C. elegans.
Article
Environmental Sciences
Yun Wang, Tingting Gai, Lianfeng Zhang, Liangwen Chen, Shunchang Wang, Tao Ye, Weiru Zhang
Summary: This study used the nematode C. elegans as an animal model to investigate the neurobehavioral and developmental effects of BPA. The results showed that BPA caused neurobehavioral toxicities, decreased growth and survival rate, and damaged neurons in the nematode. In addition, BPA induced oxidative damage. The findings suggest that neurobehavioral and developmental toxicity of BPA may be attributed to neurotransmission abnormality and oxidative damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Rong Zhou, Yue Yu, Weidong Zhang, Dayong Wang, Yanan Bai, Yixuan Wang, Yuanqing Bu
Summary: Using Caenorhabditis elegans as a model, this study examined the toxic effects of six insecticides commonly used in agriculture on sensory perception. It was found that exposure to these insecticides at low concentrations resulted in severe deficits in sensory perceptions in nematodes. The relative neurotoxicity of these insecticides to C. elegans was also determined. In addition, post-treatment with an antioxidant effectively suppressed the production of reactive oxygen species and damages of sensory perceptions induced by the insecticides. Overall, the study highlights the potential toxicity of these insecticides on environmental organisms and the role of oxidative stress in affecting sensory perceptions.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Cell Biology
Hadi Tabarraei, Brandon M. Waddell, Kelly Raymond, Sydney M. Murray, Ying Wang, Keith P. Choe, Cheng-Wei Wu
Summary: CCR4-NOT is a versatile eukaryotic protein complex that regulates gene expression at multiple steps. This study shows that a subunit of CCR4-NOT, ccf-1, is required for the transcriptional response to cadmium and acrylamide stress in C. elegans. Knockdown of ccf-1 attenuates the activation of stress-protective genes, leading to decreased stress resistance and lifespan in C. elegans.
Article
Environmental Sciences
Shiling Liu, Qiqi Wu, Yanru Zhong, Zongzhe He, Zhen Wang, Rui Li, Minghua Wang
Summary: Fosthiazate, a potent nematicide, has been used extensively for controlling root-knot nematodes and other herbivorous nematodes. However, its toxicity to non-target nematodes is still unclear. In this study, we investigated the toxicity and mechanisms of fosthiazate in Caenorhabditis elegans, a non-target nematode species. Our results showed that fosthiazate exposure above 0.01 mg/L caused growth inhibition, locomotion impairment, and reproductive damage in the nematodes. Reactive oxygen species production and lipofuscin accumulation were increased in nematodes exposed to 1 mg/L fosthiazate. The activity of acetylcholinesterase was significantly inhibited by 0.1 mg/L fosthiazate treatment. Furthermore, exposure to 10 mg/L fosthiazate altered the expression of genes involved in oxidative stress, reproduction, and nerve function. The cyp-35a family gene was found to be responsible for the metabolism of fosthiazate in C. elegans, with the cyp-35a5 subtype being the most sensitive. These findings suggest that oxidative stress, reproductive and neurological disorders play crucial roles in the toxicity of fosthiazate in C. elegans and may have implications for soil nematodes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Wenxi Jiang, Wende Yan, Qianlong Tan, Yunmu Xiao, Yang Shi, Junjie Lei, Ziqian Li, Yuanyuan Hou, Ting Liu, Yong Li
Summary: The increased emission and accumulation of micro- or nanoplastics (M-NPs) have posed a severely threaten to organisms in the environment. Though the toxicity of M-NPs has been observed in many species, the fundamental factors determining the biotoxicity are rarely expounded on. In this work, typical polystyrene (PS) M-NPs were set up with a multiparameter variation in size gradient, surface charge contrast and concentration variant, and evaluated by the Caenorhabditis elegans (C. elegans) model. From the endpoints of body length, brood size, survival rate and lifespan, an adverse effect was found on the growth and development of C. elegans caused by PSs. In general, the toxicity of PS was found to be concentrated- and size-dependent, with 100 nm positively charged nano-PS having the highest physio-toxicity. Monitoring by fluorescent imaging, it showed that positively charged nano-PS was mainly ingested and accumulated in the intestinal tract of C. elegans. In addition, the penetrated PS induced severe biological stress reactions with the increase of reactive oxygen species (ROS) and lipofuscin. Furthermore, the following expression of antioxidation-related enzymes was activated in vivo as indicated by the GFP-labelled C. elegans. All the results supplied visually toxic parameters of M-NPs to organisms, which sheds light on the biosecurity and ecological risks of M-NPs in the future.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Minyan Li, Sha Wang, Chunmei Fu, Hongyu Chen, Yuxia Su, Peng Wu, Xinhao Yan, Juanjuan Gao
Summary: Parkinson's disease (PD) is characterized by oxidative stress and this study investigated the neuroprotective effects of salidroside (Sal) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells. Sal effectively regulated oxidative stress and prevented the transmission of pathologic α-synuclein in the cells. These findings provide insights into potential protective mechanisms against neurodegenerative diseases and synucleinopathies.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Atsuki En, Shuo Takanashi, Rena Okazaki, Michihiko Fujii
Summary: This study identified a mutant oxy-7 in the nematode Caenorhabditis elegans that showed increased sensitivity to reactive oxygen species (ROS) due to a causative mutation in the gene Y71H2AM.9. Knockdown of the human homolog SLC30A9 also resulted in increased ROS production in human cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Tessa Sinnige, Georg Meisl, Thomas C. T. Michaels, Michele Vendruscolo, Tuomas P. J. Knowles, Richard Morimoto
Summary: Protein aggregation in a Caenorhabditis elegans model is controlled by independent, stochastic nucleation events in individual cells, highlighting the importance of biophysical principles in governing the overall progression of polyQ aggregation in a living animal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Medicinal
Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou, Ying-Xiu Li
Summary: The marine bacterium Planococcus maritimu ML1206 was found to have antioxidant properties and could enhance the ability of nematodes to resist oxidative stress and extend their lifespan. These findings suggest that ML1206 has potential anti-aging and antioxidant functions and could be used in aquaculture and as a dietary supplement.
Article
Environmental Sciences
Yunjiang Yu, Shihui Tan, Dongli Xie, Hongyan Li, Haibo Chen, Yao Dang, Mingdeng Xiang
Summary: This study investigated the neurotoxic effects of photoaged polystyrene (P-PS) on Caenorhabditis elegans, revealing that photoaging accelerated the aging process of MPs and caused severe neurotoxicity, potentially through abnormal neurotransmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Huijie Li, Hao Li, Ning Zuo, Yi Liu, Di Lang, Christian Steinberg, Bo Pan, Baoshan Xing
Summary: Environmentally persistent free radicals (EPFRs) have attracted extensive attention due to their potential toxicity. In this study, the direct toxicity of EPFRs was confirmed by comparing systems without EPFRs, and it was found that EPFRs-containing particles exhibited significant toxicity to Caenorhabditis elegans (C. elegans), while the parent chemical and intermediate degradation products did not. EPFRs mediated the generation of reactive oxygen species and increased gene expressions related to oxidative stress, biotransformation, energy homeostasis, survival, proliferation, cell and embryonic development in C. elegans.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Ferrer, Harshini Suresh, Abel Santamaria, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study found that exposure to MeHg can induce STAT3 activation in mouse hypothalamic neuronal cells, exacerbating oxidative stress and antioxidant responses. It suggests that the STAT3 signaling pathway plays an important role in responding to MeHg-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, Research & Experimental
Meihua Jin, Chun Wang, Yifeng Xu, Zijing Zhang, Xueyan Wu, Runfa Ye, Qinggao Zhang, Donghe Han
Summary: This review tracks and summarizes studies from the past eight years, elucidating the pharmacological effects of Salidroside on inflammation, oxidative stress, apoptosis, autophagy, and neuronal regeneration, as well as assessing its regulatory effect on various signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Haifeng Li, Linnan Su, Sheng Chen, Libin Zhao, Hongyu Wang, Fei Ding, Hong Chen, Ruona Shi, Yulan Wang, Zebo Huang
Article
Food Science & Technology
Sixu Zhao, Qiong Cheng, Qiong Peng, Xuesong Yu, Xiquan Yin, Ming Liang, Chung Wah Ma, Zebo Huang, Weizhang Jia
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Chemistry, Medicinal
Weizhang Jia, Qiong Peng, Linnan Su, Xuesong Yu, Chung Wah Ma, Ming Liang, Xiquan Yin, Yongdong Zou, Zebo Huang
Article
Geriatrics & Gerontology
Yahui Ding, Zhiyang Zhang, Zhongbao Yue, Liugang Ding, Yong Zhou, Zebo Huang, Hongliang Huang
REJUVENATION RESEARCH
(2019)
Article
Food Science & Technology
Kun-Ping Li, Min Yuan, Zhuo-Ru He, Qi Wu, Chu-Mei Zhang, Zhi-Li Lei, Xiang-Lu Rong, Zebo Huang, Jeremy E. Turnbull, Jiao Guo
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
Article
Geriatrics & Gerontology
Lingyun Xiao, Haifeng Li, Jing Tian, Nanxiang Jin, Ju Zhang, Fan Yang, Ling Zhou, Qiangqiang Wang, Zebo Huang
REJUVENATION RESEARCH
(2020)
Article
Plant Sciences
Wanwan Zhang, Yifang Wei, Xiaoxiao Cao, Kaixin Guo, Qiangqiang Wang, Xiaochun Xiao, Xufeng Zhai, Dingding Wang, Zebo Huang
Summary: The Crassostrea oyster peptide preparation COP3 has shown promising effects in increasing testosterone and cAMP levels in male mice, enhancing NOS activity in the penile region, and stimulating testosterone and NO production in Leydig-derived cells. Its upregulation of genes associated with sex hormone secretion pathways and a conserved steroidogenic enzyme suggests its potential in addressing erectile dysfunction.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Guohuan Zhong, Wenfeng Pan, Ziliang Huang, Kaixin Guo, Jingjing Hu, Peihua Liu, Sheng Chen, Yulan Wang, Liping Ai, Zebo Huang
Summary: This study revealed distinct physicochemical and biofunctional properties of N. sphaeroides polysaccharides during colony growth stages, with a significant decrease in high/low molecular weight ratio. Both polysaccharides and oligosaccharides demonstrated antioxidant activities, while only oligosaccharides showed neuroprotective effects, suggesting their potential as novel geroprotectors. Additionally, oligosaccharides were found to upregulate stress and proteostasis-associated genes in C. elegans.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Cell Biology
Meng Lu, Ajay Mishra, Chiara Boschetti, Jing Lin, Yushuang Liu, Hongliang Huang, Clemens F. Kaminski, Zebo Huang, Alan Tunnacliffe, Gabriele S. Kaminski Schierle
Summary: Sea cucumber peptides exhibit antioxidant activity, alleviating oxidative stress at both cellular and organism levels, and may be attractive as nutritional supplements for healthy ageing.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Integrative & Complementary Medicine
Sutticha Ruangchuay, Qiang-qiang Wang, Liang-yi Wang, Jing Lin, Yong-chao Wang, Guo-huan Zhong, Katesarin Maneenoon, Ze-bo Huang, Sasitorn Chusri
Summary: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Furthermore, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood. Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were identified.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Chemistry, Applied
Dansi Huang, Chao Li, Qing Chen, Xing Xie, Xiong Fu, Chun Chen, Qiang Huang, Zebo Huang, Hao Dong
Summary: Rosa roxburghii Tratt pomace (RRTP) was extracted to obtain free and bound phenolic fractions, which showed dose-dependent scavenging of radicals and improved survival rates in paraquat-exposed nematodes by enhancing SOD and CAT activities. These results suggest RRTP as a good and cost-effective source of natural antioxidants.
Review
Food Science & Technology
Yuqing Wang, Kaixin Guo, Qiangqiang Wang, Guohuan Zhong, Wenjun Zhang, Yiyi Jiang, Xinliang Mao, Xiaomin Li, Zebo Huang
Summary: This article discusses the pros and cons of using Caenorhabditis elegans as a dietary model and provides an overview of its experimental strengths and recent advances in nutritional studies. It also reviews the current challenges and potential solutions for using C. elegans as a nutritional model, and outlines future perspectives for the development of chemically defined nematode food.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Editorial Material
Pharmacology & Pharmacy
Zebo Huang, Long Ma, Ajay Mishra, Jeremy E. Turnbull, Haijun Tu
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peihua Liu, Jingjing Hu, Qiangqiang Wang, Jianhua Tan, Jian Wei, Hongbo Yang, Shuping Tang, Hongliang Huang, Yongdong Zou, Zebo Huang
Summary: This study aims to investigate the feasibility of isolating water-soluble biopolymers from seaweed hydrothermal waste and their potential applications. Efficient isolation of polymeric substances from Saccharina japonica blanching water was achieved, showing the coproduction potential of biopolymers from blanching wastewater. The resulting biopolymers were found to have polysaccharidic nature with distinct structural features and demonstrated compatibility and freshness when used in cosmetic creams.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kaixin Guo, Linnan Su, Yongchao Wang, Huihui Liu, Jing Lin, Peng Cheng, Xiquan Yin, Ming Liang, Qiangqiang Wang, Zebo Huang